Search Results - "Granger, Jonathan"

Myocardial death and dysfunction after ischemia-reperfusion injury require CaMKIIδ oxidation by Wu, Yuejin, Wang, Qinchuan, Feng, Ning, Granger, Jonathan M., Anderson, Mark E.

“…Reactive oxygen species (ROS) contribute to myocardial death during ischemia-reperfusion (I/R) injury, but detailed knowledge of molecular pathways connecting…”
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Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death by Umapathi, Priya, Mesubi, Olurotimi O., Banerjee, Partha S., Abrol, Neha, Wang, Qinchuan, Luczak, Elizabeth D., Wu, Yuejin, Granger, Jonathan M., Wei, An-Chi, Reyes Gaido, Oscar E., Florea, Liliana, Talbot, C. Conover, Hart, Gerald W., Zachara, Natasha E., Anderson, Mark E.

“…Heart failure is a leading cause of death worldwide and is associated with the rising prevalence of obesity, hypertension, and diabetes. -GlcNAcylation (the…”
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Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy by Luczak, Elizabeth D., Wu, Yuejin, Granger, Jonathan M., Joiner, Mei-ling A., Wilson, Nicholas R., Gupta, Ashish, Umapathi, Priya, Murphy, Kevin R., Reyes Gaido, Oscar E., Sabet, Amin, Corradini, Eleonora, Tseng, Wen-Wei, Wang, Yibin, Heck, Albert J. R., Wei, An-Chi, Weiss, Robert G., Anderson, Mark E.

“…Despite the clear association between myocardial injury, heart failure and depressed myocardial energetics, little is known about upstream signals responsible…”
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Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms by Mesubi, Olurotimi O, Rokita, Adam G, Abrol, Neha, Wu, Yuejin, Chen, Biyi, Wang, Qinchuan, Granger, Jonathan M, Tucker-Bartley, Anthony, Luczak, Elizabeth D, Murphy, Kevin R, Umapathi, Priya, Banerjee, Partha S, Boronina, Tatiana N, Cole, Robert N, Maier, Lars S, Wehrens, Xander H, Pomerantz, Joel L, Song, Long-Sheng, Ahima, Rexford S, Hart, Gerald W, Zachara, Natasha E, Anderson, Mark E

“…Diabetes mellitus (DM) and atrial fibrillation (AF) are major unsolved public health problems, and diabetes is an independent risk factor for AF. However, the…”
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CaMKII exacerbates heart failure progression by activating class I HDACs by Zhang, Manling, Yang, Xue, Zimmerman, Raymond J., Wang, Qin, Ross, Mark A., Granger, Jonathan M., Luczak, Elizabeth D., Bedja, Djahida, Jiang, Hong, Feng, Ning

“…Persistent cardiac Ca2+/calmodulin dependent Kinase II (CaMKII) activation plays an essential role in heart failure development. However, the molecular…”
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MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII by Konstantinidis, Klitos, Bezzerides, Vassilios J, Lai, Lo, Isbell, Holly M, Wei, An-Chi, Wu, Yuejin, Viswanathan, Meera C, Blum, Ian D, Granger, Jonathan M, Heims-Waldron, Danielle, Zhang, Donghui, Luczak, Elizabeth D, Murphy, Kevin R, Lu, Fujian, Gratz, Daniel H, Manta, Bruno, Wang, Qiang, Wang, Qinchuan, Kolodkin, Alex L, Gladyshev, Vadim N, Hund, Thomas J, Pu, William T, Wu, Mark N, Cammarato, Anthony, Bianchet, Mario A, Shea, Madeline A, Levine, Rodney L, Anderson, Mark E

“…Oxidant stress can contribute to health and disease. Here we show that invertebrates and vertebrates share a common stereospecific redox pathway that protects…”
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An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor by Reyes Gaido, Oscar E, Pavlaki, Nikoleta, Granger, Jonathan M, Mesubi, Olurotimi O, Liu, Bian, Lin, Brian L, Long, Alan, Walker, David, Mayourian, Joshua, Schole, Kate L, Terrillion, Chantelle E, Nkashama, Lubika J, Hulsurkar, Mohit M, Dorn, Lauren E, Ferrero, Kimberly M, Huganir, Richard L, Müller, Frank U, Wehrens, Xander H T, Liu, Jun O, Luczak, Elizabeth D, Bezzerides, Vassilios J, Anderson, Mark E

“…Ca /calmodulin-dependent protein kinase II (CaMKII) hyperactivity causes cardiac arrhythmias, a major source of morbidity and mortality worldwide. Despite…”
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Abstract P3149: Effect Of SGLT2 Inhibitors On Atrial Fibrillation Susceptibility In Diabetic Mice by Granger, Jonathan, Nguyen, Pauline, Mesubi, Olurotimi O

“…Abstract only Background: Diabetes mellitus (DM) and heart failure (HF) are independent risk factors for atrial fibrillation (AF), the commonest clinical…”
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Abstract P1160: Genome-wide CRISPR Screen Reveals Genetic And Small Molecule Modifiers Of Ca 2+ -mediated Cell Death by Reyes Gaido, Oscar, Granger, Jonathan, Schole, Kate, Luczak, Elizabeth D

“…Abstract only Ca 2+ is a ubiquitous and highly regulated signaling ion in living cells. Thus, Ca 2+ is typically maintained at a low intracellular…”
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Abstract P3195: Mitochondrial CaMKII Drives Cardiometabolic Dysfunction In Heart Failure by Ferrero, Kimberly, Cole, Robert, Foster, D B, Granger, Jonathan, O'Rourke, Brian, Kass, David A, Luczak, Elizabeth

“…Abstract only Background: Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is an established negative regulator of cardiac injury. Both the expression…”
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Abstract 2242: Genetic modulation of protein O-GlcNAcylation affects Atrial Fibrillation susceptibility by Mesubi, Olurotimi, Granger, Jonathan, Nguyen, Pauline, Vocadlo, David, Zachara, Natasha, Anderson, Mark

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PO-01-174 GENETIC MODULATION OF PROTEIN O-GLCNACYLATION AFFECTS ATRIAL FIBRILLATION SUSCEPTIBILITY by Granger, Jonathan, Nguyen, Pauline, Vocadlo, David, Zachara, Natasha, Mesubi, Olurotimi O.

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Cognate status and cross-script translation priming by VOGA, Madeleine, GRAINGER, Jonathan

“…Greek-French bilinguals were tested in three masked priming experiments with Greek primes and French targets. Related primes were the translation equivalents…”
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Monitoring CaMKII in Mitochondria by Murphy, Kevin R., Wang, Qinchuan, Granger, Jonathan, Karandikar, Vedika, Bortoli, Gianna, Zhang, Xi, Luczak, Elizabeth, Li, Rong, Anderson, Mark E.

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Abstract 457: Ca2+/calmodulin Dependent Kinase II Exacerbates Heart Failure Progression Through Activation of Class I Histone Deacetylases by Zhang, Manling, Luczak, Elizabeth D, Granger, Jonathan, Brown, Joan H, Anderson, Mark E, Feng, Ning

“…Abstract only Background: Persistent cardiac Ca2+/calmodulin dependent Kinase II (CaMKII) activation in patients receiving standard heart failure therapies,…”
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Abstract 13500: An Improved Reporter Identifies Ruxolitinib as a Potent and Cardioprotective CaMKII Inhibitor by Reyes Gaido, Oscar E, Pavlaki, Nikoleta, Granger, Jonathan, Mesubi, Olurotimi O, Liu, Bian, Lin, Brian L, Long, Alan, Walker, David, Mayourian, Joshua, Schole, Kate L, Terrillion, Chantelle E, Nkashama, Lubika J, Hulsurkar, Mohit M, Dorn, Lauren E, Ferrero, Kimberly M, Huganir, Richard L, Muller, Frank U, Wehrens, Xander H, Liu, Jun O, Luczak, Elizabeth, Bezzerides, Vassilios J, Anderson, Mark E

“…Abstract only Background: Ca 2+ /Calmodulin-dependent protein kinase II (CaMKII) hyperactivity is an established driver of cardiac arrhythmias. Despite proven…”
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Splitting Up: Finding a New Way to Monitor Mitochondrial CaMKII Using SplitGFP by Murphy, Kevin R., Wang, Qinchuan, Granger, Jonathan, Bortoli, Gianna, Yang, Jinying, Zhang, Xi, Luczak, Elizabeth, Li, Rong, Anderson, Mark E.

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Oxidized CaMKII and 0-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms by Mesubi, Olurotimi O, Rokita, Adam G, Abrol, Neha, Wu, Yuejin, Chen, Biyi, Wang, Qinchuan, Granger, Jonathan M, Tucker- Bartley, Anthony, Luczak, Elizabeth D, Murphy, Kevin R, Umapathi, Priya, Banerjee, Partha S, Boronina, Tatiana N, Cole, Robert N, Maier, Lars S, Wehrens, Xander H, Pomerantz, Joel L, Song, Long-Sheng, Ahima, Rexford S, Hart, Gerald W, Zachara, Natasha E, Anderson, Mark E

“…Diabetes mellitus (DM) and atrial fibrillation (AF) are major unsolved public health problems, and diabetes is an independent risk factor for AF. However, the…”
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CaMKII oxidation is a performance-disease tradeoff in vertebrate evolution by Wang, Qinchuan, Hernandez-Ochoa, Erick O., Blum, Ian D., Granger, Jonathan M., Yang, Jinying, Viswanathan, Meera C., Aja, Susan, Liu, Naili, Antonescu, Corina M., Florea, Liliana D., Conover Talbot, C., Mohr, David, Wagner, Kathryn R., Regot, Sergi, Lovering, Richard M., Wu, Mark N., Cammarato, Anthony R., Schneider, Martin F., Bever, Gabriel S., Anderson, Mark E.

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CaMKII oxidation causes increased atrial fibrillation in diabetic mice by Mesubi, Olurotimi, Rokita, Adam, Abrol, Neha, Wu, Yuejin, Chen, Biyi, Wang, Qinchuan, Granger, Jonathan, Luczak, Elizabeth, Maier, Lars, Wehrens, Xander, Pomenrantz, Joel, Song, Long-Sheng, Hart, Gerald, Anderson, Mark

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