Search Results - "Granger, D"

Reperfusion injury and reactive oxygen species: The evolution of a concept by Granger, D Neil, Kvietys, Peter R

“…Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-deprived and oxygen-starved organs following the restoration of blood flow…”
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Hypercoagulability and Platelet Abnormalities in Inflammatory Bowel Disease by Senchenkova, Elena, Seifert, Hilary, Granger, D Neil

“…Patients with inflammatory bowel disease (IBD) exhibit a threefold higher risk for development of systemic thrombosis than the general population. Although the…”
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Platelets: a critical link between inflammation and microvascular dysfunction by Stokes, Karen Y., Granger, D. Neil

“…Inflammation is an underlying feature of a variety of human diseases. An important manifestation of this pathophysiological response is microvascular…”
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Role of reactive oxygen and nitrogen species in the vascular responses to inflammation by Kvietys, Peter R, Granger, D Neil

“…Inflammation is a complex and potentially life-threatening condition that involves the participation of a variety of chemical mediators, signaling pathways,…”
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Leukocyte Recruitment and Ischemic Brain Injury by Yilmaz, Gokhan, Granger, D. Neil

“…Leukocytes are recruited into the cerebral microcirculation following an ischemic insult. The leukocyte–endothelial cell adhesion manifested within a few hours…”
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Blood cells and endothelial barrier function by Rodrigues, Stephen F, Granger, D Neil

“…The barrier properties of endothelial cells are critical for the maintenance of water and protein balance between the intravascular and extravascular…”
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Inhibition of CD147 (Cluster of Differentiation 147) Ameliorates Acute Ischemic Stroke in Mice by Reducing Thromboinflammation by Jin, Rong, Xiao, Adam Y, Chen, Rui, Granger, D Neil, Li, Guohong

“…Inflammation and thrombosis currently are recognized as critical contributors to the pathogenesis of ischemic stroke. CD147 (cluster of differentiation 147),…”
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Cell adhesion molecules and ischemic stroke by Yilmaz, Gokhan, Granger, D. Neil

“…Objective: To describe the role of adhesion molecules in ischemic stroke. Methods: A PubMed search of literature pertaining to this study was conducted in…”
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Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation by Senchenkova, Elena Y, Ansari, Junaid, Becker, Felix, Vital, Shantel A, Al-Yafeai, Zaki, Sparkenbaugh, Erica M, Pawlinski, Rafal, Stokes, Karen Y, Carroll, Jennifer L, Dragoi, Ana-Maria, Qin, Cheng Xue, Ritchie, Rebecca H, Sun, Hai, Cuellar-Saenz, Hugo H, Rubinstein, Mara R, Han, Yiping W, Orr, A Wayne, Perretti, Mauro, Granger, D Neil, Gavins, Felicity N.E

“…BACKGROUND:Ischemia reperfusion injury (I/RI) is a common complication of cardiovascular diseases. Resolution of detrimental I/RI-generated prothrombotic and…”
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Formyl-Peptide Receptor 2/3/Lipoxin A4 Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in Cardiovascular Disease by Vital, Shantel A, Becker, Felix, Holloway, Paul M, Russell, Janice, Perretti, Mauro, Granger, D Neil, Gavins, Felicity N.E

“…BACKGROUND—Platelet activation at sites of vascular injury is essential for hemostasis, but it is also a major pathomechanism underlying ischemic injury…”
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Abundance and survival of microbial aerosols in the troposphere and stratosphere by Bryan, N. C., Christner, B. C., Guzik, T. G., Granger, D. J., Stewart, M. F.

“…Bioaerosol transport in the atmosphere disperses microbial species between continents, affects human and plant health, and may influence hydrologic cycling…”
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Inflammatory bowel disease: A paradigm for the link between coagulation and inflammation by Yoshida, Hideo, Granger, D. Neil

“…Inflammatory bowel diseases (IBDs) are associated with platelet activation and an increased risk for thromboembolism. While the mechanisms that underlie the…”
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Role of T lymphocytes and interferon-γ in ischemic stroke by YILMAZ, Gokhan, ARUMUGAM, Thiruma V, STOKES, Karen Y, GRANGER, D. Neil

“…Although lymphocyte recruitment and activation are associated with cerebral ischemia-reperfusion (I/R) injury, the contributions of specific lymphocyte…”
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Soluble CD40 ligand stimulates CD40-dependent activation of the β2 integrin Mac-1 and protein kinase C zeda (PKCζ) in neutrophils: implications for neutrophil-platelet interactions and neutrophil oxidative burst by Jin, Rong, Yu, Shiyong, Song, Zifang, Zhu, Xiaolei, Wang, Cuiping, Yan, Jinchuan, Wu, Fusheng, Nanda, Anil, Granger, D Neil, Li, Guohong

“…Recent work has revealed an essential involvement of soluble CD40L (sCD40L) in inflammation and vascular disease. Activated platelets are the major source of…”
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Simvastatin Attenuates Stroke-induced Splenic Atrophy and Lung Susceptibility to Spontaneous Bacterial Infection in Mice by RONG JIN, XIAOLEI ZHU, LIN LIU, NANDA, Anil, NEIL GRANGER, D, GUOHONG LI

“…Statins are widely used in the primary and secondary prevention of ischemic stroke, but their effects on stroke-induced immunodepression and poststroke…”
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Novel Role of T Cells and IL-6 (Interleukin-6) in Angiotensin II–Induced Microvascular Dysfunction by Senchenkova, Elena Y, Russell, Janice, Yildirim, Alper, Granger, D Neil, Gavins, Felicity N.E

“…Hypertension is an established risk factor for subsequent cardiovascular diseases, with Ang II (angiotensin II) playing a major role in mediating thrombotic…”
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Role of blood cells in ischaemia–reperfusion induced endothelial barrier failure by Rodrigues, Stephen F., Granger, D. Neil

“…Ischaemia and reperfusion (I/R) elicits an acute inflammatory response that is characterized by the recruitment of inflammatory cells, oxidative stress, and…”
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Adipose tissue: A motor for the inflammation associated with obesity by Vachharajani, Vidula, Granger, D. Neil

“…Obesity is a worldwide epidemic that continues to grow at an alarming rate. This condition increases the morbidity and mortality associated with both acute and…”
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Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease by Ansari, Junaid, Senchenkova, Elena Y., Vital, Shantel A., Al-Yafeai, Zaki, Kaur, Gaganpreet, Sparkenbaugh, Erica M., Orr, A. Wayne, Pawlinski, Rafal, Hebbel, Robert P., Granger, D. Neil, Kubes, Paul, Gavins, Felicity N.E.

“…Neutrophils play a crucial role in the intertwined processes of thrombosis and inflammation. An altered neutrophil phenotype may contribute to inadequate…”
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Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia-Reperfusion by TERAO, Satoshi, YILMAZ, Gokhan, STOKES, Karen Y, RUSSELL, Janice, ISHIKAWA, Mami, KAWASE, Takeshi, NEIL GRANGER, D

“…Although chemokines have been implicated in cardiovascular diseases, few studies have addressed the role of these inflammatory mediators in ischemic stroke…”
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