Search Results - "Grange, Robert M H"
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Sulfide catabolism ameliorates hypoxic brain injury
Published in Nature communications (25-05-2021)“…The mammalian brain is highly vulnerable to oxygen deprivation, yet the mechanism underlying the brain’s sensitivity to hypoxia is incompletely understood…”
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Identification of Candidate miRNA Biomarkers for Glaucoma
Published in Investigative ophthalmology & visual science (01-01-2019)“…Glaucoma, a leading cause of blindness worldwide, often remains undetected until irreversible vision loss has occurred. Treatments focus on lowering…”
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Electronic cigarette vaping with aged coils causes acute lung injury in mice
Published in Archives of toxicology (01-12-2022)“…Electronic cigarettes (e-cigarettes) have been used widely as an alternative to conventional cigarettes and have become particularly popular among young…”
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Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
Published in Cell (30-05-2019)“…Friedreich’s ataxia (FRDA) is a devastating, multisystemic disorder caused by recessive mutations in the mitochondrial protein frataxin (FXN). FXN participates…”
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Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells
Published in Science (American Association for the Advancement of Science) (01-01-2021)“…Neuroendocrine (NE) cells are epithelial cells that possess many of the characteristics of neurons, including the presence of secretory vesicles and the…”
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Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature
Published in British journal of pharmacology (01-06-2022)“…Background and Purpose cGMP underpins the bioactivity of NO and natriuretic peptides and is key to cardiovascular homeostasis. cGMP‐driven responses are…”
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Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome
Published in Molecular genetics and metabolism (01-05-2021)“…Leigh syndrome is a severe mitochondrial neurodegenerative disease with no effective treatment. In the Ndufs4−/− mouse model of Leigh syndrome, continuously…”
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