Sulcus fluid bone marker levels and the outcome of surgical treatment of peri-implantitis

Aim To analyse change in selected bone markers in peri‐implant sulcus fluid (PISF) sampled before treatment and after 12 months and test correlation with change in disease progression. Materials and Methods Peri‐implant sulcus fluid was sampled from 32 patients in a randomized, clinical study compar...

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Published in:	Journal of clinical periodontology Vol. 41; no. 4; pp. 424 - 431
Main Authors:	Wohlfahrt, Johan C., Aass, Anne M., Granfeldt, Finn, Lyngstadaas, Ståle P., Reseland, Janne E.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-04-2014
Subjects:	Adiponectin - analysis Biocompatible Materials - chemistry Biomarkers Biomarkers - analysis bone markers Bones Debridement - methods Dental Implants Dentistry Disease Progression Follow-Up Studies Gingival Crevicular Fluid - chemistry Humans Insulin - analysis Interleukin-6 - analysis Leptin - analysis Matrix Metalloproteinase 8 - analysis Maxillofacial surgery Orthodontics Osteocalcin - analysis Osteopontin - analysis Osteoprotegerin - analysis Parathyroid Hormone - analysis peri-implantitis Peri-Implantitis - surgery Periodontal Pocket - surgery Prospective Studies Reconstructive Surgical Procedures - methods Surgical Flaps - surgery Surgical outcomes surgical treatment Titanium - chemistry Transplants & implants Treatment Outcome Tumor Necrosis Factor-alpha - analysis bone markers surgical treatment dental implants peri-implantitis
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Summary:	Aim To analyse change in selected bone markers in peri‐implant sulcus fluid (PISF) sampled before treatment and after 12 months and test correlation with change in disease progression. Materials and Methods Peri‐implant sulcus fluid was sampled from 32 patients in a randomized, clinical study comparing peri‐implant defect re‐construction with or without porous titanium granules. Matrix metalloproteinase 8 levels were measured using the Quantikine Human Total MMP‐8 (DMP800) ELISA. Multianalyte profiling of the level of bone markers [interleukin‐6, osteprotegerin (OPG), osteocalcin, leptin, osteopontin, parathyroid hormone, tumour necrosis factor‐α, adiponectin and insulin] was performed by Luminex using Human Bone Panel IB. Changes in bone marker levels were compared and correlation with clinical findings was tested. Results No differences in clinical parameter or bone marker levels between test and control group were found. When comparing bone marker levels irrespective of treatment allocation between baseline and 12 months, a significant reduction in total protein, matrix metalloproteinase ‐8, interleukin‐6, OPG, leptin and adiponectin were demonstrated. Positive correlations were found between the reduction in interleukin‐6 (r = 0.43), insulin (r = 0.38) and matrix metalloproteinase‐8 (r = 0.47) concentration, and probing pocket depth reduction. Conclusion Peri‐implantitis surgical treatment induced some reduction of the studied bone markers. Conclusive evidence for correlation between change in bone marker concentrations with disease resolution was not found.
Bibliography:	ark:/67375/WNG-Q50FTDDJ-Z Norwegian Research Council - No. 181896 istex:3F1EF879D5CB85BC61C7AA893DE508002C51E219 ArticleID:JCPE12229 Tigran AB Professor Lyngstadaas is a board member of Tigran AB and Dr. Wohlfahrt was previously a member of Tigran AB, Clinical Advisory Board. Professor Lyngstadaas and Dr. Wohlfahrt have received financial reimbursement when lecturing for Tigran AB. Conflict of interest and source of funding statement This study was in part sponsored by a grant from Tigran AB, Malmö, Sweden and in part by grant 181896 from the Norwegian Research Council. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0303-6979 1600-051X
DOI:	10.1111/jcpe.12229