Search Results - "Granero, Froilán"

Regenerative Effects of Transplanted Mesenchymal Stem Cells in Fracture Healing by Granero‐Moltó, Froilán, Weis, Jared A., Miga, Michael I., Landis, Benjamin, Myers, Timothy J., O'Rear, Lynda, Longobardi, Lara, Jansen, E. Duco, Mortlock, Douglas P., Spagnoli, Anna

“…Mesenchymal stem cells (MSC) have a therapeutic potential in patients with fractures to reduce the time of healing and treat nonunions. The use of MSC to treat…”
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Tissue Mimicry in Morphology and Composition Promotes Hierarchical Matrix Remodeling of Invading Stem Cells in Osteochondral and Meniscus Scaffolds by Stuckensen, Kai, Schwab, Andrea, Knauer, Markus, Muiños‐López, Emma, Ehlicke, Franziska, Reboredo, Jenny, Granero‐Moltó, Froilán, Gbureck, Uwe, Prósper, Felipe, Walles, Heike, Groll, Jürgen

“…An integral approach toward in situ tissue engineering through scaffolds that mimic tissue with regard to both tissue architecture and biochemical composition…”
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Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II) by Lamo-Espinosa, José María, Mora, Gonzalo, Blanco, Juan F, Granero-Moltó, Froilán, Núñez-Córdoba, Jorge María, López-Elío, Silvia, Andreu, Enrique, Sánchez-Guijo, Fermín, Aquerreta, José Dámaso, Bondía, José María, Valentí-Azcárate, Andrés, Del Consuelo Del Cañizo, María, Villarón, Eva María, Valentí-Nin, Juan Ramón, Prósper, Felipe

“…Mesenchymal stromal cells (MSCs) are a promising option to treat knee osteoarthritis (OA). Their safety and usefulness have been reported in several short-term…”
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Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice by Valdés‐Fernández, José, López‐Martínez, Tania, Ripalda‐Cemboráin, Purificación, Calvo, Isabel A, Sáez, Borja, Romero‐Torrecilla, Juan Antonio, Aldazabal, Javier, Muiños‐López, Emma, Montiel, Verónica, Orbe, Josune, Rodríguez, José Antonio, Páramo, José Antonio, Prósper, Felipe, Granero‐Moltó, Froilán

“…ABSTRACT The remodeling of the extracellular matrix is a central function in endochondral ossification and bone homeostasis. During secondary fracture healing,…”
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Mesenchymal Stem Cells Expressing Insulin‐like Growth Factor‐I (MSCIGF) Promote Fracture Healing and Restore New Bone Formation in Irs1 Knockout Mice: Analyses of MSCIGF Autocrine and Paracrine Regenerative Effects by Granero‐Moltó, Froilán, Myers, Timothy J., Weis, Jared A., Longobardi, Lara, Li, Tieshi, Yan, Yun, Case, Natasha, Rubin, Janet, Spagnoli, Anna

“…Failures of fracture repair (nonunions) occur in 10% of all fractures. The use of mesenchymal stem cells (MSC) in tissue regeneration appears to be rationale,…”
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Hypoxia and Reactive Oxygen Species Homeostasis in Mesenchymal Progenitor Cells Define a Molecular Mechanism for Fracture Nonunion by Muinos‐López, Emma, Ripalda‐Cemboráin, Purificación, López‐Martínez, Tania, González‐Gil, Ana B., Lamo‐Espinosa, José M., Valentí, Andrés, Mortlock, Douglas P., Valentí, Juan R., Prósper, Felipe, Granero‐Moltó, Froilán

“…Fracture nonunion is a major complication of bone fracture regeneration and repair. The molecular mechanisms that result in fracture nonunion appearance are…”
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Silane-modified hydroxyapatite nanoparticles incorporated into polydioxanone/poly(lactide-co-caprolactone) creates a novel toughened nanocomposite with improved material properties and in vivo inflammatory responses by Shiroud Heidari, Behzad, Lopez, Emma Muinos, Chen, Peilin, Ruan, Rui, Vahabli, Ebrahim, Davachi, Seyed Mohammad, Granero-Moltó, Froilán, De-Juan-Pardo, Elena M., Zheng, Minghao, Doyle, Barry

“…The interface tissue between bone and soft tissues, such as tendon and ligament (TL), is highly prone to injury. Although different biomaterials have been…”
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Autologous bioscaffolds based on different concentrations of platelet rich plasma and synovial fluid as a vehicle for mesenchymal stem cells by Garate, Ane, Sánchez, Pello, Delgado, Diego, Bilbao, Ane Miren, Muiños‐López, Emma, Granero‐Moltó, Froilán, Orive, Gorka, Prosper, Felipe, Pedraz, José Luis, Sánchez, Mikel

“…In the field of tissue engineering, diverse types of bioscaffolds are being developed currently for osteochondral defect applications. In this work, a novel…”
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Periosteum‐derived mesenchymal progenitor cells in engineered implants promote fracture healing in a critical‐size defect rat model by González‐Gil, Ana B., Lamo‐Espinosa, José M., Muiños‐López, Emma, Ripalda‐Cemboráin, Purificación, Abizanda, Gloria, Valdés‐Fernández, José, López‐Martínez, Tania, Flandes‐Iparraguirre, María, Andreu, Ion, Elizalde, María Reyes, Stuckensen, Kai, Groll, Jürgen, De‐Juan‐Pardo, Elena M., Prósper, Felipe, Granero‐Moltó, Froilán

“…An attractive alternative to bone autografts is the use of autologous mesenchymal progenitor cells (MSCs) in combination with biomaterials. We compared the…”
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Novel hybrid biocomposites for tendon grafts: The addition of silk to polydioxanone and poly(lactide-co-caprolactone) enhances material properties, in vitro and in vivo biocompatibility by Shiroud Heidari, Behzad, Muiños Lopez, Emma, Harrington, Emma, Ruan, Rui, Chen, Peilin, Davachi, Seyed Mohammad, Allardyce, Benjamin, Rajkhowa, Rangam, Dilley, Rodney, Granero-Moltó, Froilán, De-Juan-Pardo, Elena M., Zheng, Minghao, Doyle, Barry

“…Biopolymers play a critical role as scaffolds used in tendon and ligament (TL) regeneration. Although advanced biopolymer materials have been proposed with…”
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CC-Chemokine Receptor-2 Expression in Osteoblasts Contributes to Cartilage and Bone Damage during Post-Traumatic Osteoarthritis by Willcockson, Helen, Ozkan, Huseyin, Valdés-Fernández, José, Arbeeva, Liubov, Mucahit, Esra, Musawwir, Layla, Hooper, Lola B, Granero-Moltó, Froilán, Prósper, Felipe, Longobardi, Lara

“…In osteoarthritis (OA), bone changes are radiological hallmarks and are considered important for disease progression. The C-C chemokine receptor-2 (CCR2) has…”
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Anisotropic Cryostructured Collagen Scaffolds for Efficient Delivery of RhBMP–2 and Enhanced Bone Regeneration by Stuckensen, Kai, Lamo-Espinosa, José M., Muiños-López, Emma, Ripalda-Cemboráin, Purificación, López-Martínez, Tania, Iglesias, Elena, Abizanda, Gloria, Andreu, Ion, Flandes-Iparraguirre, María, Pons-Villanueva, Juan, Elizalde, Reyes, Nickel, Joachim, Ewald, Andrea, Gbureck, Uwe, Prósper, Felipe, Groll, Jürgen, Granero-Moltó, Froilán

“…In the treatment of bone non-unions, an alternative to bone autografts is the use of bone morphogenetic proteins (BMPs), e.g., BMP–2, BMP–7, with powerful…”
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Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II) by Lamo-Espinosa, José M, Mora, Gonzalo, Blanco, Juan F, Granero-Moltó, Froilán, Nuñez-Córdoba, Jorge M, Sánchez-Echenique, Carmen, Bondía, José M, Aquerreta, Jesús Dámaso, Andreu, Enrique J, Ornilla, Enrique, Villarón, Eva M, Valentí-Azcárate, Andrés, Sánchez-Guijo, Fermín, Del Cañizo, María Consuelo, Valentí-Nin, Juan Ramón, Prósper, Felipe

“…Mesenchymal stromal cells are a promising option to treat knee osteoarthritis. Their safety and usefulness must be confirmed and the optimal dose established…”
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Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model by Albiñana-Cunningham, Juan N, Ripalda-Cemboráin, Purificación, Labiano, Tania, Echeveste, José I, Granero-Moltó, Froilán, Alfonso-Olmos, Matías

“…TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β…”
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Phase II multicenter randomized controlled clinical trial on the efficacy of intra-articular injection of autologous bone marrow mesenchymal stem cells with platelet rich plasma for the treatment of knee osteoarthritis by Lamo-Espinosa, José María, Blanco, Juan F, Sánchez, Mikel, Moreno, Victoria, Granero-Moltó, Froilán, Sánchez-Guijo, Fermín, Crespo-Cullel, Íñigo, Mora, Gonzalo, San Vicente, Diego Delgado, Pompei-Fernández, Orlando, Aquerreta, Jesús Dámaso, Núñez-Córdoba, Jorge María, Vitoria Sola, María, Valentí-Azcárate, Andrés, Andreu, Enrique J, Del Consuelo Del Cañizo, María, Valentí-Nin, Juan Ramón, Prósper, Felipe

“…Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their…”
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A finite element inverse analysis to assess functional improvement during the fracture healing process by Weis, Jared A, Miga, Michael I, Granero-Moltó, Froilán, Spagnoli, Anna

“…Abstract Assessment of the restoration of load-bearing function is the central goal in the study of fracture healing process. During the fracture healing, two…”
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Comparison of microCT and an inverse finite element approach for biomechanical analysis: Results in a mesenchymal stem cell therapeutic system for fracture healing by Weis, Jared A, Granero-Moltó, Froilán, Myers, Timothy J, Longobardi, Lara, Spagnoli, Anna, Miga, Michael I

“…Abstract An important concern in the study of fracture healing is the ability to assess mechanical integrity in response to candidate therapeutics in…”
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Goodpasture Antigen-binding Protein and Its Spliced Variant, Ceramide Transfer Protein, Have Different Functions in the Modulation of Apoptosis during Zebrafish Development by Granero-Moltó, Froilán, Sarmah, Swapnalee, O'Rear, Lynda, Spagnoli, Anna, Abrahamson, Dale, Saus, Juan, Hudson, Billy G., Knapik, Ela W.

“…Human Goodpasture antigen-binding protein (GPBP) is an atypical protein kinase that phosphorylates the Goodpasture auto-antigen, the α3 chain of collagen IV…”
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An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration by Romero-Torrecilla, Juan Antonio, Lamo-Espinosa, José María, Ripalda-Cemboráin, Purificación, López-Martínez, Tania, Abizanda, Gloria, Riera-Álvarez, Luis, de Galarreta-Moriones, Sergio Ruiz, López-Barberena, Asier, Rodríguez-Flórez, Naiara, Elizalde, Reyes, Jayawarna, Vineetha, Valdés-Fernández, José, de Anleo, Miguel Echanove-González, Childs, Peter, de Juan-Pardo, Elena, Salmeron-Sanchez, Manuel, Prósper, Felipe, Muiños-López, Emma, Granero-Moltó, Froilán

“…During bone regeneration, the periosteum acts as a carrier for key regenerative cues, delivering osteochondroprogenitor cells and crucial growth factors to the…”
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Delayed fracture healing in Mmp10 (Stromelysin 2) knockout mice: Molecular and cellular mechanism by Valdés-Fernández, José, López-Martínez, Tania, Ripalda-Cemboráin, Purificación, Calvo, Isabel, Sáez, Borja, Romero-Torrecilla, Juan Antonio, Orbe, Josune, Rodríguez, José Antonio, Páramo, José Antonio, Prósper, Felipe, Granero-Moltó, Froilán

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