Search Results - "Grandis, Jennifer Rubin"

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy by SICHUAN XI, GOODING, William E, GRANDIS, Jennifer Rubin

“…The development of more effective prevention and treatment strategies for solid tumors is limited by an incomplete understanding of the critical growth…”
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STAT signaling in head and neck cancer by Song, J I, Grandis, J R

“…The upper aerodigestive tract is predisposed to the formation of multiple primary tumors due to field cancerization. TGF-alpha/EGFR autocrine signaling appears…”
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Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma by THOMAS, Sufi Mary, BHOLA, Neil E, QING ZHANG, CONTRUCCI, Sarah C, WENTZEL, Abbey L, FREILINO, Maria L, GOODING, William E, SIEGFRIED, Jill M, CHAN, Daniel C, RUBIN GRANDIS, Jennifer

“…G protein-coupled receptors (GPCR) and the epidermal growth factor receptor (EGFR) are often both overexpressed and contribute to the growth of cancers by…”
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The changing face of malignant (necrotising) external otitis: clinical, radiological, and anatomic correlations by Rubin Grandis, Jennifer, Branstetter, 4th, Barton F, Yu, Victor L

“…Malignant (necrotising) external otitis is an invasive infection of the external auditory canal. Although elderly patients with diabetes remain the population…”
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The current state of head and neck cancer gene therapy by Thomas, Sufi Mary, Grandis, Jennifer Rubin

“…The incidence of head and neck cancer continues to increase worldwide, with tobacco exposure and human papillomavirus type 16 infections being the major…”
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Constitutive Activation of Signal Transducer and Activator of Transcription 5 Contributes to Tumor Growth, Epithelial-Mesenchymal Transition, and Resistance to Epidermal Growth Factor Receptor Targeting by KOPPIKAR, Priya, LUI, Vivian Wai Yan, MAN, David, SICHUAN XI, CHAI, Raymond Liu, NELSON, Elizabeth, TOBEY, Allison B. J, RUBIN GRANDIS, Jennifer

“…Purpose: Signal transducer and activator of transcription 5 (STAT5) is activated in squamous cell carcinoma of the head and neck (SCCHN), where targeting of…”
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Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor by WAI YAN LUI, Vivian, THOMAS, Sufi Mary, QING ZHANG, WENTZEL, Abbey Lynn, SIEGFRIED, Jill Marie, YAN LI, Joyce, RUBIN GRANDIS, Jennifer

“…Head and neck squamous cell carcinomas (HNSCC) are characterized by upregulation of the epidermal growth factor receptor (EGFR), where EGFR serves as a…”
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Stat3 activation in prostatic carcinomas by Dhir, Rajiv, Ni, Zuyao, Lou, Wei, DeMiguel, Fernando, Grandis, Jennifer Rubin, Gao, Allen C.

“…BACKGROUND Activated Stat3 is found in various types of immortal cell lines and cancers. We and others have previously demonstrated that Stat3 is…”
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Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2 by STEINMAN, Richard A, WENTZEL, Abbey, YALIN LU, STEHLE, Christine, GRANDIS, Jennifer Rubin

“…The signal transducing protein Stat3 activates gene transcription in cells in response to multiple cytokines. Constitutive activation of Stat3 has been…”
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Enhanced Antiangiogenic Therapy of Squamous Cell Carcinoma by Combined Endostatin and Epidermal Growth Factor Receptor-Antisense Therapy by Li, Mengfeng, Ye, Caisheng, Feng, Chong, Riedel, Frank, Liu, Xiaoning, Zeng, Qing, Grandis, Jennifer Rubin

“…Purpose: We tested the combined effects of antiangiogenic endostatin and epidermal growth factor receptor (EGFR) antisense gene therapy on squamous cell…”
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Signaling through the epidermal growth factor receptor during the development of malignancy by Grandis, Jennifer Rubin, Sok, John C

“…The epidermal growth factor receptor (EGFR) is overexpressed and/or constitutively activated in a variety of human malignancies. Detection of increased…”
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Differential function of STAT5 isoforms in head and neck cancer growth control by LEONG, Paul L, SICHUAN XI, DRENNING, Stephanie D, DYER, Kevin F, WENTZEL, Abbey L, LERNER, Edwina C, SMITHGALL, Thomas E, GRANDIS, Jennifer Rubin

“…Up-regulation of the epidermal growth factor receptor (EGFR) is critical for the loss of growth control in a variety of human cancers, including squamous cell…”
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Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation by Thomas, Sufi Mary, Grandis, Jennifer Rubin

“…The epidermal growth factor receptor (EGFR) is overexpressed in many solid tumours. Targeting EGFR is emerging as a potential strategy to incorporate into…”
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New advances in molecular approaches to head and neck squamous cell carcinoma by Sahu, Nivedita, Grandis, Jennifer Rubin

“…Head and neck squamous cell cancer is the sixth most common cancer in the world. Despite advances in combined modality therapy, poor outcomes continue to be…”
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STAT3 as a therapeutic target in head and neck cancer by Leeman, Rebecca J, Lui, Vivian Wai Yan, Grandis, Jennifer Rubin

“…The signal transducer and activator of transcription (STAT) proteins relay signals from cytokine receptors and receptor tyrosine kinases on the cell surface to…”
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Cross-Talk between Estrogen Receptor and Epidermal Growth Factor Receptor in Head and Neck Squamous Cell Carcinoma by Egloff, Ann Marie, Rothstein, Mary E, Seethala, Raja, Siegfried, Jill M, Grandis, Jennifer Rubin, Stabile, Laura P

“…Purpose: This study aimed to characterize estrogen receptor expression and signaling in head and neck squamous cell carcinoma (HNSCC) cell lines and patient…”
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Targeted Inhibition of Stat3 with a Decoy Oligonucleotide Abrogates Head and Neck Cancer Cell Growth by Leong, Paul L., Andrews, Genevieve A., Johnson, Daniel E., Dyer, Kevin F., Sichuan Xi, Mai, Jeffrey C., Robbins, Paul D., Gadiparthi, Seshu, Burke, Nancy A., Watkins, Simon F., Grandis, Jennifer Rubin

“…The transcription factor signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a variety of cancers including squamous cell…”
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Improving Response Rates to EGFR-Targeted Therapies for Head and Neck Squamous Cell Carcinoma: Candidate Predictive Biomarkers and Combination Treatment with Src Inhibitors by Egloff, Ann Marie, Grandis, Jennifer Rubin

“…The epidermal growth factor receptor- (EGFR-) directed antibody, cetuximab, was FDA-approved for the treatment of squamous cell carcinoma of the head and neck…”
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Constitutive Activation of Stat3 Signaling Abrogates Apoptosis in Squamous Cell Carcinogenesis in vivo by Grandis, Jennifer Rubin, Drenning, Stephanie D., Zeng, Qing, Watkins, Simon C., Melhem, Mona F., Endo, Sohei, Johnson, Daniel E., Huang, Leaf, He, Yukai, Kim, Jae D.

“…Field cancerization predisposes the upper aerodigestive tract mucosa to the formation of multiple primary tumors, when exposed to environmental carcinogens…”
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Phosphorylation of TNF-α Converting Enzyme by Gastrin-Releasing Peptide Induces Amphiregulin Release and EGF Receptor Activation by Zhang, Qing, Thomas, Sufi M., Lui, Vivian Wai Yan, Xi, Sichuan, Siegfried, Jill M., Fan, Huizhou, Smithgall, Thomas E., Mills, Gordon B., Grandis, Jennifer Rubin

“…G protein-coupled receptors induce EGF receptor (EGFR) signaling, leading to the proliferation and invasion of cancer cells. Elucidation of the mechanism of…”
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