Search Results - "Grand, Roger J A"

Serotype-Specific Inactivation of the Cellular DNA Damage Response during Adenovirus Infection by FORRESTER, Natalie A, SEDGWICK, Garry G, THOMAS, Anoushka, BLACKFORD, Andrew N, SPEISEDER, Thomas, DOBNER, Thomas, BYRD, Philip J, STEWART, Grant S, TURNELL, Andrew S, GRAND, Roger J. A

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Adenovirus E4orf3 Targets Transcriptional Intermediary Factor 1γ for Proteasome-Dependent Degradation during Infection by FORRESTER, Natalie A, PATEL, Rakesh N, DOBNER, Thomas, GRAND, Roger J. A, MARTIN, Ashley, TURNELL, Andrew S, SPEISEDER, Thomas, GROITL, Peter, SEDGWICK, Garry G, SHIMWELL, Neil J, SEED, Robert I, CATNAIGH, Pól O, MCCABE, Christopher J, STEWART, Grant S

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The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression by Turnell, Andrew S, Stewart, Grant S, Grand, Roger J. A, Rookes, Susan M, Martin, Ashley, Yamano, Hiroyuki, Elledge, Stephen J, Gallimore, Phillip H

“…The anaphase-promoting complex/cyclosome (APC/C) is a multicomponent E3 ubiquitin ligase that, by targeting protein substrates for 26S proteasome-mediated…”
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A Role for E1B-AP5 in ATR Signaling Pathways during Adenovirus Infection by BLACKFORD, Andrew N, BRUTON, Rachel K, DIRLIK, Orkide, STEWART, Grant S, TAYLOR, A. Malcolm R, DOBNER, Thomas, GRAND, Roger J. A, TURNELL, Andrew S

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Comparison of E1A CR3-Dependent Transcriptional Activation across Six Different Human Adenovirus Subgroups by ABLACK, Jailal N. G, PELKA, Peter, YOUSEF, Ahmed F, TURNELL, Andrew S, GRAND, Roger J. A, MYMRYK, Joe S

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Characterization of the 55-Residue Protein Encoded by the 9S E1A mRNA of Species C Adenovirus by MILLER, Matthew S, PELKA, Peter, FONSECA, Gregory J, COHEN, Michael J, KELLY, Jenna N, BARR, Stephen D, GRAND, Roger J. A, TURNELL, Andrew S, WHYTE, Peter, MYMRYK, Joe S

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Identification of a Second CtBP Binding Site in Adenovirus Type 5 E1A Conserved Region 3 by BRUTON, Rachel K, PELKA, Peter, MAPP, Katie L, FONSECA, Gregory J, TORCHIA, Joseph, TURNELL, Andrew S, MYMRYK, Joe S, GRAND, Roger J. A

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Adenovirus E1B 55-Kilodalton Protein : Multiple Roles in Viral Infection and Cell Transformation by BLACKFORD, Andrew N, GRAND, Roger J. A

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Recruitment of CBP/p300, TATA-Binding Protein, and S8 to Distinct Regions at the N Terminus of Adenovirus E1A by RASTI, Mozhgan, GRAND, Roger J. A, MYMRYK, Joe S, GALLIMORE, Phillip H, TURNELL, Andrew S

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Roles for APIS and the 20S proteasome in adenovirus E1A-dependent transcription by Rasti, Mozhgan, Grand, Roger JA, Yousef, Ahmed F, Shuen, Michael, Mymryk, Joe S, Gallimore, Phillip H, Turnell, Andrew S

“…We have determined distinct roles for different proteasome complexes in adenovirus (Ad) E1A‐dependent transcription. We show that the 19S ATPase, S8, as a…”
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Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation by Blackford, Andrew N., Patel, Rakesh N., Forrester, Natalie A., Theil, Kathrin, Groitl, Peter, Stewart, Grant S., Taylor, A. Malcolm R., Morgan, Iain M., Dobner, Thomas, Grand, Roger J. A., Turnell, Andrew S., Shenk, Thomas E.

“…Activation of the cellular DNA damage response is detrimental to adenovirus (Ad) infection. Ad has therefore evolved a number of strategies to inhibit ATM- and…”
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Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP by Pelka, Peter, Ablack, Jailal N.G, Torchia, Joseph, Turnell, Andrew S, Grand, Roger J.A, Mymryk, Joe S

“…The human adenovirus type 5 (HAdV-5) E1A 13S oncoprotein is a potent regulator of gene expression and is used extensively as a model for transcriptional…”
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Adenovirus E1A interacts directly with, and regulates the level of expression of, the immunoproteasome component MECL1 by Berhane, Sarah, Aresté, Cristina, Ablack, Jailal N, Ryan, Gordon B, Blackbourn, David J, Mymryk, Joe S, Turnell, Andrew S, Steele, Jane C, Grand, Roger J.A

“…Abstract Proteasomes represent the major non-lysosomal mechanism responsible for the degradation of proteins. Following interferon γ treatment 3 proteasome…”
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ATM activation in hypoxia - causes and consequences by Olcina, Monica M, Grand, Roger JA, Hammond, Ester M

“…The DNA damage response is a complex signaling cascade that is triggered by cellular stress. This response is essential for the maintenance of genomic…”
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The Replicative Capacities of Large E1B-Null Group A and Group C Adenoviruses Are Independent of Host Cell p53 Status by Turnell, A S, Grand, R J, Gallimore, P H

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The effect of CtBP1 binding on the structure of the C-terminal region of adenovirus 12 early region 1A by Molloy, David P, Barral, Paola M, Gallimore, Phillip H, Grand, Roger J.A

“…Abstract Adenovirus early region 1A (AdE1A) binds to the C-terminal binding protein 1 (CtBP1) primarily through a highly conserved PXDLS motif located close to…”
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The Targeting of the Proteasomal Regulatory Subunit S2 by Adenovirus E1A Causes Inhibition of Proteasomal Activity and Increased p53 Expression by Zhang, Xian, Turnell, Andrew S., Gorbea, Carlos, Mymryk, Joe S., Gallimore, Phillip H., Grand, Roger J.A.

“…Although adenovirus early region 1A (AdE1A) can modulate protein expression through its interaction with transcriptional regulators it can also influence the…”
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Acetylation at a lysine residue adjacent to the CtBP binding motif within adenovirus 12 E1A causes structural disruption and limited reduction of CtBP binding by Molloy, David, Mapp, Katie L., Webster, Rachel, Gallimore, Phillip H., Grand, Roger J.A.

“…C-terminal binding protein (CtBP) has been shown to bind to a highly conserved five-amino-acid motif (PXDLS) located very close to the C-terminus of adenovirus…”
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Cellular consequences of thrombin-receptor activation by Grand, R J, Turnell, A S, Grabham, P W

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Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis by Sedgwick, G G, Townsend, K, Martin, A, Shimwell, N J, Grand, R J A, Stewart, G S, Nilsson, J, Turnell, A S

“…The anaphase-promoting complex/cyclosome (APC/C) is an ubiquitin ligase that functions during mitosis. Here we identify the transcriptional regulator,…”
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