Search Results - "Grand, Roger J."

Pathogenicity and virulence of human adenovirus F41: Possible links to severe hepatitis in children by Grand, Roger J.

“…Over 100 human adenoviruses (HAdVs) have been isolated and allocated to seven species, A-G. Species F comprises two members-HAdV-F40 and HAdV-F41. As their…”
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DNA viruses and the cellular DNA-damage response by TURNELL, Andrew S, GRAND, Roger J

“…It is clear that a number of host-cell factors facilitate virus replication and, conversely, a number of other factors possess inherent antiviral activity…”
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Regulation of DNA-End Resection by hnRNPU-like Proteins Promotes DNA Double-Strand Break Signaling and Repair by Polo, Sophie E., Blackford, Andrew N., Chapman, J. Ross, Baskcomb, Linda, Gravel, Serge, Rusch, Andre, Thomas, Anoushka, Blundred, Rachel, Smith, Philippa, Kzhyshkowska, Julia, Dobner, Thomas, Taylor, A. Malcolm R., Turnell, Andrew S., Stewart, Grant S., Grand, Roger J., Jackson, Stephen P.

“…DNA double-strand break (DSB) signaling and repair are critical for cell viability, and rely on highly coordinated pathways whose molecular organization is…”
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Modulation of DNA damage and repair pathways by human tumour viruses by Hollingworth, Robert, Grand, Roger J

“…With between 10% and 15% of human cancers attributable to viral infection, there is great interest, from both a scientific and clinical viewpoint, as to how…”
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The Regulatory Properties of the Ccr4-Not Complex by Chalabi Hagkarim, Nafiseh, Grand, Roger J

“…The mammalian Ccr4-Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of…”
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Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus by Hollingworth, Robert, Horniblow, Richard D, Forrest, Calum, Stewart, Grant S, Grand, Roger J

“…Double-strand breaks (DSBs) in DNA are recognized by the Ku70/80 heterodimer and the MRE11-RAD50-NBS1 (MRN) complex and result in activation of the DNA-PK and…”
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Activation of the DNA Damage Response by RNA Viruses by Ryan, Ellis L, Hollingworth, Robert, Grand, Roger J

“…RNA viruses are a genetically diverse group of pathogens that are responsible for some of the most prevalent and lethal human diseases. Numerous viruses…”
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Adenovirus E1B 55-Kilodalton Protein : Multiple Roles in Viral Infection and Cell Transformation by BLACKFORD, Andrew N, GRAND, Roger J. A

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Identification of Adenovirus E1B-55K Interaction Partners through a Common Binding Motif by Chalabi Hagkarim, Nafiseh, Ip, Wing-Hang, Bertzbach, Luca D, Abualfaraj, Tareq, Dobner, Thomas, Molloy, David P, Stewart, Grant S, Grand, Roger J

“…The adenovirus C5 E1B-55K protein is crucial for viral replication and is expressed early during infection. It can interact with E4orf6 to form a complex that…”
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Serotype-Specific Inactivation of the Cellular DNA Damage Response during Adenovirus Infection by FORRESTER, Natalie A, SEDGWICK, Garry G, THOMAS, Anoushka, BLACKFORD, Andrew N, SPEISEDER, Thomas, DOBNER, Thomas, BYRD, Philip J, STEWART, Grant S, TURNELL, Andrew S, GRAND, Roger J. A

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The Promotion of Genomic Instability in Human Fibroblasts by Adenovirus 12 Early Region 1B 55K Protein in the Absence of Viral Infection by Abualfaraj, Tareq, Hagkarim, Nafiseh Chalabi, Hollingworth, Robert, Grange, Laura, Jhujh, Satpal, Stewart, Grant S, Grand, Roger J

“…The adenovirus 12 early region 1B55K (Ad12E1B55K) protein has long been known to cause non-random damage to chromosomes 1 and 17 in human cells. These sites,…”
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SARS-CoV-2 and the DNA damage response by Grand, Roger J

“…The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized…”
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A link between severe hepatitis in children and adenovirus 41 and adeno-associated virus 2 infections by Grand, Roger J

“…Over the past few months there have been reports of severe acute hepatitis in several hundred, otherwise healthy, immunocompetent young children. Several…”
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Disruption of the Mammalian Ccr4-Not Complex Contributes to Transcription-Mediated Genome Instability by Hagkarim, Nafiseh Chalabi, Hajkarim, Morteza Chalabi, Suzuki, Toru, Fujiwara, Toshinobu, Winkler, G Sebastiaan, Stewart, Grant S, Grand, Roger J

“…The mammalian Ccr4-Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of…”
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Activation of DNA Damage Response Pathways during Lytic Replication of KSHV by Hollingworth, Robert, Skalka, George L, Stewart, Grant S, Hislop, Andrew D, Blackbourn, David J, Grand, Roger J

“…Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of several human malignancies. Human tumour viruses such as KSHV are known to interact…”
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Adenovirus E4orf3 Targets Transcriptional Intermediary Factor 1γ for Proteasome-Dependent Degradation during Infection by FORRESTER, Natalie A, PATEL, Rakesh N, DOBNER, Thomas, GRAND, Roger J. A, MARTIN, Ashley, TURNELL, Andrew S, SPEISEDER, Thomas, GROITL, Peter, SEDGWICK, Garry G, SHIMWELL, Neil J, SEED, Robert I, CATNAIGH, Pól O, MCCABE, Christopher J, STEWART, Grant S

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The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression by Turnell, Andrew S, Stewart, Grant S, Grand, Roger J. A, Rookes, Susan M, Martin, Ashley, Yamano, Hiroyuki, Elledge, Stephen J, Gallimore, Phillip H

“…The anaphase-promoting complex/cyclosome (APC/C) is a multicomponent E3 ubiquitin ligase that, by targeting protein substrates for 26S proteasome-mediated…”
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Correction: Hollingworth, R.; Grand, R.J. Modulation of DNA Damage and Repair Pathways by Human Tumour Viruses. Viruses 2015, 7, 2542-2591 by Hollingworth, Robert, Grand, Roger J

“…We have noted a number of errors in the references of this manuscript.[...]…”
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A Role for E1B-AP5 in ATR Signaling Pathways during Adenovirus Infection by BLACKFORD, Andrew N, BRUTON, Rachel K, DIRLIK, Orkide, STEWART, Grant S, TAYLOR, A. Malcolm R, DOBNER, Thomas, GRAND, Roger J. A, TURNELL, Andrew S

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Comparison of E1A CR3-Dependent Transcriptional Activation across Six Different Human Adenovirus Subgroups by ABLACK, Jailal N. G, PELKA, Peter, YOUSEF, Ahmed F, TURNELL, Andrew S, GRAND, Roger J. A, MYMRYK, Joe S

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