Search Results - "Grand, R J A"

Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis by Sedgwick, G G, Townsend, K, Martin, A, Shimwell, N J, Grand, R J A, Stewart, G S, Nilsson, J, Turnell, A S

“…The anaphase-promoting complex/cyclosome (APC/C) is an ubiquitin ligase that functions during mitosis. Here we identify the transcriptional regulator,…”
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C-terminal-binding protein interacting protein binds directly to adenovirus early region 1A through its N-terminal region and conserved region 3 by BRUTON, R. K, RASTI, M, TURNELL, A. S, GRAND, R. J. A, MAPP, K. L, YOUNG, N, CARTER, R. Z, ABRAMOWICZ, I. A, SEDGWICK, G. G, ONION, D. F, SHUEN, M, MYMRYK, J. S

“…C-terminal-binding protein interacting protein (CtIP) was first isolated as a binding partner of C-terminal-binding protein (CtBP). It is considered to…”
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Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase Akt signalling pathway by Shimwell, N J, Martin, A, Bruton, R K, Blackford, A N, Sedgwick, G G, Gallimore, P H, Turnell, A S, Grand, R J A

“…Using mass spectrometric analysis insulin receptor substrate 4 (IRS-4) has been identified as a novel adenovirus 5 early region 1A (Ad5E1A)-binding protein…”
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The biochemistry of ras p21 by GRAND, R. J. A, OWEN, D

“…The sum of our knowledge, in biochemical and biophysical terms, of p21 is immense and yet its function within the cell remains virtually unknown. It seems an…”
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Transcriptional intermediary factor 1[gamma] binds to the anaphase-promoting complex/cyclosome and promotes mitosisa by Sedgwick, G G, Townsend, K, Martin, A, Shimwell, N J, Grand, R J A, Stewart, G S, Nilsson, J, Turnell, A S

“…The anaphase-promoting complex/cyclosome (APC/C) is an ubiquitin ligase that functions during mitosis. Here we identify the transcriptional regulator,…”
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Comparison of amino acid sequence of troponin I from different striated muscles by Wilkinson, J. M, Grand, R. J. A

“…The sequence of troponin I from fast and slow skeletal and cardiac muscle shows strong homology in the region which binds to actin and is responsible for…”
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The relationship between biological activity and primary structure of troponin I from white skeletal muscle of the rabbit by Syska, H, Wilkinson, J M, Grand, R J, Perry, S V

“…1. A series of defined peptides which span the complete sequence were produced from troponin I isolated from white skeletal muscle of the rabbit. 2. Two…”
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Adenovirus Type 12 Early Region 1 Proteins: A Study of their Subcellular Localization and Protein-Protein Interactions by Grand, Roger J. A, Gallimore, Phillip H

“…Cancer Research Campaign Laboratories, Department of Cancer Studies, University of Birmingham, Medical School, Birmingham B15 2TJ, U.K. Subcellular…”
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The use of beta-galactosidase fusion proteins encoding the early region 1 transforming proteins of adenovirus type 12 to examine the humoral response in tumour-bearing animals by Merrick, Ruth M, Grand, Roger J. A, Brown, Judith C, Gallimore, Phillip H

“…Department of Cancer Studies, Cancer Research Campaign Laboratories, The Medical School, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K. Sera…”
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Preparation of the alkali and P light chains of chicken gizzard myosin. Amino acid sequence of the alkali light chain by Grand, R J, Perry, S V

“…1. A simple method is described for the purification of the alkali and P light chains from chicken gizzard myosin. 2. The sequence of the alkali light chain…”
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The Expression of the Adenovirus 12 Early Region 1B 19K Protein Using a Recombinant Simian Virus 40 System by Mitchison, Hannah M, Grand, Roger J. A, Byrd, Philip J, Johnson, Gerald D, Parton, Adrian, Gallimore, Phillip H

“…1 Department of Cancer Studies, Cancer Research Campaign Laboratories, Clinical Research Block, The Medical School, University of Birmingham, Birmingham B15…”
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Distribution of isoforms of the myofibrillar proteins in myoid cells of thymus by DHOOT, G. K, DRANSFIELD, I, GRAND, R. J. A, PERRY, S. V

“…Myoid cells of calf and rat thymus have been identified by staining with a monoclonal antibody to the heavy chain of myosin that is not isoform specific…”
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Evidence for the Expression of Protein IX in Some Rat Cells Transformed with Adenovirus Type 12 Early Region 1 DNA by Grand, Roger J. A, Smith, Kate J, Gallimore, Phillip H

“…Cancer Research Campaign Laboratories, Department of Cancer Studies, The Medical School, University of Birmingham, Birmingham B15 2TJ, U.K. Sera were produced…”
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Acylation of viral and eukaryotic proteins by Grand, R J

“…Post-translational modification has long been recognized as a way in which the properties of protein molecules may be subtly altered after synthesis of the…”
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Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells by Traverse, S, Cohen, P, Paterson, H, Marshall, C, Rapp, U, Grand, R J

“…Plasma membrane-enriched fractions were prepared from human embryonic retinal cells transformed with either adenovirus E1A and oncogenic ras DNA, or E1A and…”
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Enhanced expression of p53 in human cells infected with mutant adenoviruses by Grand, R J, Grant, M L, Gallimore, P H

“…The expression of p53 in human cells infected with wild-type (wt) and mutant adenoviruses has been examined. With wt Ad5 and Ad12, and Ad12 viruses carrying…”
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Apoptosis in Burkitt lymphoma cells is driven by c-myc by Milner, A E, Grand, R J, Waters, C M, Gregory, C D

“…Chromosomal translocation and subsequent de-regulation of the c-myc proto-oncogene are considered to be critical events in the multi-stage evolution of Burkitt…”
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Consequences of disruption of the interaction between p53 and the larger adenovirus early region 1B protein in adenovirus E1 transformed human cells by HUTTON, F. G, TURNELL, A. S, GALLIMORE, P. H, GRAND, R. J. A

“…The adenovirus early region 1B (Ad E1B) genes have no transforming capability of their own but markedly increase the transformation frequency of Ad E1A…”
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Definition of a major p53 binding site on Ad2E1B58K protein and a possible nuclear localization signal on the Ad12E1B54K protein by GRAND, R. J. A, PARKHILL, J, SZESTAK, T, ROOKES, S. M, ROBERTS, S, GALLIMORE, P. H

“…Previous studies have established that adenovirus 2/5 early region 1B (Ad E1B) 58K protein binds p53 strongly and co-localizes with it to cytoplasmic dense…”
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Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome by GRAND, R. J. A, TURNELL, A. S, MASON, G. G. F, WANG, W, MILNER, A. E, MYMRYK, J. S, ROOKES, S. M, RIVETT, A. J, GALLIMORE, P. H

“…Adenovirus early region 1A (Ad E1A) is a multifunctional protein which is essential for adenovirus-mediated transformation and oncogenesis. Whilst E1A is…”
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