Search Results - "Granchi, C"

Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials by Granchi, C, Bertini, S, Macchia, M, Minutolo, F

“…In many different species, lactate dehydrogenase (LDH) constitutes a major checkpoint of anaerobic glycolysis, by catalyzing the reduction of pyruvate into…”
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Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia by Maftouh, M, Avan, A, Sciarrillo, R, Granchi, C, Leon, L G, Rani, R, Funel, N, Smid, K, Honeywell, R, Boggi, U, Minutolo, F, Peters, G J, Giovannetti, E

“…Background: Hypoxia is a driving force in pancreatic-ductal-adenocarcinoma (PDAC) growth, metastasis and chemoresistance. The muscle-isoform of lactate…”
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Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways by Allison, S J, Knight, J R P, Granchi, C, Rani, R, Minutolo, F, Milner, J, Phillips, R M

“…Most cancer cells use aerobic glycolysis to fuel their growth. The enzyme lactate dehydrogenase-A (LDH-A) is key to cancer’s glycolytic phenotype, catalysing…”
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Phospho-Akt: a potential resistance marker to chemotherapy and therapy-target to restore sensitivity in pancreatic cancer by Giovannetti, E, Massihnia, D, Avan, A, Funel, N, Maftouh, M, Van Krieken, A, Granchi, C, Raktoe, R, Boggi, U, Aicher, B, Minutolo, F, Russo, A, Leon, L, Peters, G

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Biomechanical Comparison of Medial Collateral Ligament Reconstructions Using Computer-Assisted Navigation by Feeley, Brian T., Muller, Mark S., Allen, Answorth A., Granchi, Carrine C., Pearle, Andrew D.

“…Background The medial collateral ligament is a broad ligament that functions as the primary stabilizer against valgus knee stress, particularly at 30° of…”
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Preclinical emergence of novel lactate dehydrogenase inhibitors as potent antitumor agents in hypoxic models of pancreatic cancer: Molecular mechanisms underlying their synergistic interaction with gemcitabine by Giovannetti, E, Avan, A, Sciarrillo, R, Granchi, C, Funel, N, Macchia, M, Boggi, U, Minutolo, F, Peters, G.J

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Reliability of Navigated Knee Stability Examination: A Cadaveric Evaluation by Pearle, Andrew D., Solomon, Daniel J., Wanich, Tony, Moreau-Gaudry, Alexandre, Granchi, Carinne C., Wickiewicz, Thomas L., Warren, Russell F.

“…Background Clinical examination remains empirical and may be confusing in the setting of rotatory knee instabilities. Computerized navigation systems provide…”
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Changes in the Length of Virtual Anterior Cruciate Ligament Fibers during Stability Testing: A Comparison of Conventional Single-Bundle Reconstruction and Native Anterior Cruciate Ligament by Brophy, Robert H., Voos, James E., Shannon, Fintan J., Granchi, Carinne C., Wickiewicz, Thomas L, Warren, Russell F., Pearle, Andrew D.

“…Background Conventional tunnel positions for single-bundle (SB) transtibial anterior cruciate ligament (ACL) reconstruction are located in the posterolateral…”
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Isometry of medial collateral ligament reconstruction by Feeley, Brian T., Muller, Mark S., Allen, Answorth A., Granchi, Carinne C., Pearle, Andrew D.

“…The purpose of this study was to determine the femoral and tibial fixation sites that would result in the most isometric MCL reconstruction technique. Seven…”
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Changes in the Length of Virtual Anterior Cruciate Ligament Fibers During Stability Testing by Brophy, Robert H, Voos, James E, Shannon, Fintan J, Granchi, Carinne C, Wickiewicz, Thomas L, Warren, Russell F, Pearle, Andrew D

“…Background: Conventional tunnel positions for single-bundle (SB) transtibial anterior cruciate ligament (ACL) reconstruction are located in the posterolateral…”
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Reliability of Navigated Knee Stability Examination by Cadaveric Evaluation, A, Pearle, Andrew D, Solomon, Daniel J, Wanich, Tony, Moreau-Gaudry, Alexandre, Granchi, Carinne C, Wickiewicz, Thomas L, Warren, Russell F

“…Background: Clinical examination remains empirical and may be confusing in the setting of rotatory knee instabilities. Computerized navigation systems provide…”
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636 - Phospho-Akt: a potential resistance marker to chemotherapy and therapy-target to restore sensitivity in pancreatic cancer by Giovannetti, E., Massihnia, D., Avan, A., Funel, N., Maftouh, M., Van Krieken, A., Granchi, C., Raktoe, R., Boggi, U., Aicher, B., Minutolo, F., Russo, A., Leon, L., Peters, G.

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