Search Results - "Grancara, Silvia"
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Involvement of the biogenic active amine agmatine in mitochondrial membrane permeabilization and release of pro-apoptotic factors
Published in Amino acids (01-02-2020)“…Agmatine (AGM) produces a dual effect on the mitochondrial permeability transition (MPT) mechanism in rat liver mitochondria: at low concentrations, it induces…”
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Mitochondrial permeability transition as target of anticancer drugs
Published in Current pharmaceutical design (01-01-2014)“…Mitochondria are the cell powerhouses but also contain the mechanisms leading to cell death. Many signals converge on mitochondria to cause the…”
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An eudesman derivative from Verbesina persicifolia D.C. as a natural mild uncoupler in liver mitochondria. A new potential anti-obesity agent?
Published in Current pharmaceutical design (01-01-2014)“…4β-cinnamoyloxy,1β,3α-dihydroxyeudesm-7,8-ene (CDE) extracted from Verbesina persicifolia induces bioenergetic collapse in rat liver mitochondria (RLM),…”
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4
Electrochemical determination of hydrogen peroxide production by isolated mitochondria: A novel nanocomposite carbon–maghemite nanoparticle electrode
Published in Sensors and actuators. B, Chemical (01-01-2013)“…A simple carbon paste electrode modified with novel maghemite (γ-Fe2O3) nanoparticles, characterized by a mean diameter of about 10nm and specific surface…”
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Milestones and recent discoveries on cell death mediated by mitochondria and their interactions with biologically active amines
Published in Amino Acids (01-10-2016)“…Mitochondria represent cell “powerhouses,” being involved in energy transduction from the electrochemical gradient to ATP synthesis. The morphology of their…”
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Pathophysiological implications of mitochondrial oxidative stress mediated by mitochondriotropic agents and polyamines: the role of tyrosine phosphorylation
Published in Amino acids (01-05-2015)“…Mitochondria, once merely considered as the “powerhouse” of cells, as they generate more than 90 % of cellular ATP, are now known to play a central role in…”
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The antioxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability
Published in International journal of oncology (01-09-2018)“…Aged garlic extract (AGE) has been shown to possess therapeutic properties in cancer; however its mechanisms of action are unclear. In this study, we…”
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A novel enzyme with spermine oxidase properties in bovine liver mitochondria: Identification and kinetic characterization
Published in Free radical biology & medicine (01-04-2015)“…The uptake of spermine into mammalian mitochondria indicated the need to identify its catabolic pathway in these organelles. Bovine liver mitochondria were…”
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Spermine cycling in mitochondria is mediated by adenine nucleotide translocase activity: mechanism and pathophysiological implications
Published in Amino acids (01-10-2016)“…Spermine, besides to be transported in mitochondria by an energy dependent electrophoretic mechanism, can be also released by two different mechanisms. The…”
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Mitochondrial oxidative stress induced by Ca2+ and monoamines: different behaviour of liver and brain mitochondria in undergoing permeability transition
Published in Amino acids (01-02-2012)“…Mitochondrial permeability transition (MPT) is correlated with the opening of a nonspecific pore, the so-called transition pore, that triggers bidirectional…”
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Bidirectional fluxes of spermine across the mitochondrial membrane
Published in Amino acids (01-03-2014)“…The polyamine spermine is transported into the mitochondrial matrix by an electrophoretic mechanism having as driving force the negative electrical membrane…”
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12
Synthesis, antiproliferative and mitochondrial impairment activities of bis-alkyl-amino transplatinum complexes
Published in Bioorganic & medicinal chemistry (15-11-2013)“…A convenient synthetic route and the characterization of complexes trans-[PtCl2(L)(PPh3)] (L=Et2NH (2), (PhCH2)2NH (3), (HOCH2CH2)2NH) (4) are reported. The…”
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13
Mitochondrial oxidative stress induced by Ca super(2+) and monoamines: different behaviour of liver and brain mitochondria in undergoing permeability transition
Published in Amino acids (01-02-2012)“…Mitochondrial permeability transition (MPT) is correlated with the opening of a nonspecific pore, the so-called transition pore, that triggers bidirectional…”
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14
Mitochondrial oxidative stress induced by Ca^sup 2+^ and monoamines: different behaviour of liver and brain mitochondria in undergoing permeability transition
Published in Amino acids (01-02-2012)“…Issue Title: Role of polyamines, their analogs and transglutaminases in biological and clinical perspectives Mitochondrial permeability transition (MPT) is…”
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Further characterization of agmatine binding to mitochondrial membranes: involvement of imidazoline I2 receptor
Published in Amino acids (01-02-2012)“…Agmatine, a divalent diamine with two positive charges at physiological pH, is transported into the matrix of liver mitochondria by an energy-dependent…”
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16
Effect of peroxides on spermine transport in rat brain and liver mitochondria
Published in Amino acids (01-02-2012)“…The polyamine spermine is transported into the matrix of various types of mitochondria by a specific uniporter system identified as a protein channel. This…”
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Journal Article -
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Further characterization of agmatine binding to mitochondrial membranes: involvement of imidazoline I sub(2) receptor
Published in Amino acids (01-02-2012)“…Agmatine, a divalent diamine with two positive charges at physiological pH, is transported into the matrix of liver mitochondria by an energy-dependent…”
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Journal Article -
18
Further characterization of agmatine binding to mitochondrial membranes: involvement of imidazoline I^sub 2^ receptor
Published in Amino acids (01-02-2012)“…Issue Title: Role of polyamines, their analogs and transglutaminases in biological and clinical perspectives Agmatine, a divalent diamine with two positive…”
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