Search Results - "Granata, Alessandra"

Functional genomics in stroke: current and future applications of iPSCs and gene editing to dissect the function of risk variants by Granata, Alessandra

“…Stroke is an important disease with unmet clinical need. To uncover novel paths for treatment, it is of critical importance to develop relevant laboratory…”
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Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application by Sinha, Sanjay, Iyer, Dharini, Granata, Alessandra

“…Vascular smooth muscle cells (SMCs) arise from multiple origins during development, raising the possibility that differences in embryological origins between…”
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Cerebrovascular Disorders by Granata, Alessandra, Harshfield, Eric L, Moxon, Joseph V

“…Cerebrovascular disorders pose a global health concern. Advances in basic and clinical research, including induced pluripotent stem cell models and multi-omic…”
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In vitro platform to model the function of ionocytes in the human airway epithelium by Vilà-González, Marta, Pinte, Laetitia, Fradique, Ricardo, Causa, Erika, Kool, Heleen, Rodrat, Mayuree, Morell, Carola Maria, Al-Thani, Maha, Porter, Linsey, Guo, Wenrui, Maeshima, Ruhina, Hart, Stephen L, McCaughan, Frank, Granata, Alessandra, Sheppard, David N, Floto, R Andres, Rawlins, Emma L, Cicuta, Pietro, Vallier, Ludovic

“…Pulmonary ionocytes have been identified in the airway epithelium as a small population of ion transporting cells expressing high levels of CFTR (cystic…”
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The Dystonia-associated Protein TorsinA Modulates Synaptic Vesicle Recycling by Granata, Alessandra, Watson, Rose, Collinson, Lucy M., Schiavo, Giampietro, Warner, Thomas T.

“…The loss of a glutamic acid residue in the AAA-ATPase (ATPases associated with diverse cellular activities) torsinA is responsible for most cases of early…”
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The Histone Deacetylase 9 Stroke-Risk Variant Promotes Apoptosis and Inflammation in a Human iPSC-Derived Smooth Muscle Cells Model by Granata, Alessandra, Kasioulis, Ioannis, Serrano, Felipe, Cooper, James D, Traylor, Matthew, Sinha, Sanjay, Markus, Hugh S

“…A common variant in the Histone Deacetylase 9 ( ) gene is the strongest genetic risk for large-vessel stroke, and HDAC9 offers a novel target for therapeutic…”
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An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death by Granata, Alessandra, Serrano, Felipe, Bernard, William George, McNamara, Madeline, Low, Lucinda, Sastry, Priya, Sinha, Sanjay

“…Sanjay Sinha and colleagues use a vascular model derived from human induced pluripotent stem cells from patients with Marfan syndrome with fibrillin-1…”
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Evidence of functional redundancy between MID proteins: implications for the presentation of Opitz syndrome by Granata, Alessandra, Savery, Dawn, Hazan, Jamile, Cheung, Billy M.F., Lumsden, Andrew, Quaderi, Nandita A.

“…Opitz G/BBB syndrome (OS) is a congenital defect characterized by hypertelorism and hypospadias, but additional midline malformations are also common in OS…”
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A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration by Serrano, Felipe, Bernard, William George, Granata, Alessandra, Iyer, Dharini, Steventon, Ben, Kim, Matthew, Vallier, Ludovic, Gambardella, Laure, Sinha, Sanjay

“…The neural crest (NC) is a transient multipotent cell population present during embryonic development. The NC can give rise to multiple cell types and is…”
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Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease by Pokhilko, Alexandra, Brezzo, Gaia, Handunnetthi, Lahiru, Heilig, Raphael, Lennon, Rachel, Smith, Colin, Allan, Stuart M, Granata, Alessandra, Sinha, Sanjay, Wang, Tao, Markus, Hugh S, Naba, Alexandra, Fischer, Roman, Van Agtmael, Tom, Horsburgh, Karen, Cader, M Zameel

“…The extracellular matrix (ECM) is a key interface between the cerebrovasculature and adjacent brain tissues. Deregulation of the ECM contributes to a broad…”
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A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target by Davaapil, Hongorzul, McNamara, Madeline, Granata, Alessandra, Macrae, Robyn G.C., Hirano, Mei, Fitzek, Martina, Aragon-Martin, J.A., Child, Anne, Smith, David M., Sinha, Sanjay

“…Marfan syndrome (MFS) is a rare connective tissue disorder caused by mutations in FBN1. Patients with MFS notably suffer from aortic aneurysm and dissection…”
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CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process by Granata, Alessandra, Koo, Seong Joo, Haucke, Volker, Schiavo, Giampietro, Warner, Thomas T

“…DYT1 dystonia is caused by an autosomal dominant mutation that leads to a glutamic acid deletion in torsinA (TA), a member of the AAA+ ATPase superfamily. In…”
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Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3 by Granata, Alessandra, Bernard, William G, Zhao, Ning, Mccafferty, John, Lilly, Brenda, Sinha, Sanjay

“…Vascular smooth muscle cells (SMCs), which arise from multiple embryonic progenitors, have unique lineage-specific properties and this diversity may contribute…”
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A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases by Al-Thani, Maha, Goodwin-Trotman, Mary, Bell, Steven, Patel, Krushangi, Fleming, Lauren K., Vilain, Catheline, Abramowicz, Marc, Allan, Stuart M., Wang, Tao, Cader, M. Zameel, Horsburgh, Karen, Van Agtmael, Tom, Sinha, Sanjay, Markus, Hugh S., Granata, Alessandra

“…Cerebral small vessel disease (SVD) affects the small vessels in the brain and is a leading cause of stroke and dementia. Emerging evidence supports a role of…”
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Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology by Horsburgh, Karen, Wardlaw, Joanna M, van Agtmael, Tom, Allan, Stuart M, Ashford, Mike L J, Bath, Philip M, Brown, Rosalind, Berwick, Jason, Cader, M Zameel, Carare, Roxana O, Davis, John B, Duncombe, Jessica, Farr, Tracy D, Fowler, Jill H, Goense, Jozien, Granata, Alessandra, Hall, Catherine N, Hainsworth, Atticus H, Harvey, Adam, Hawkes, Cheryl A, Joutel, Anne, Kalaria, Rajesh N, Kehoe, Patrick G, Lawrence, Catherine B, Lockhart, Andy, Love, Seth, Macleod, Malcolm R, Macrae, I Mhairi, Markus, Hugh S, McCabe, Chris, McColl, Barry W, Meakin, Paul J, Miller, Alyson, Nedergaard, Maiken, O'Sullivan, Michael, Quinn, Terry J, Rajani, Rikesh, Saksida, Lisa M, Smith, Colin, Smith, Kenneth J, Touyz, Rhian M, Trueman, Rebecca C, Wang, Tao, Williams, Anna, Williams, Steven C R, Work, Lorraine M

“…Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a…”
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TorsinA and dystonia: from nuclear envelope to synapse by Granata, Alessandra, Schiavo, Giampietro, Warner, Thomas T

“…A GAG deletion in the DYT1 gene is responsible for the autosomal dominant movement disorder, early onset primary torsion dystonia, which is characterised by…”
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Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage by McNeilly, Sarah, Thomson, Cameron R., Gonzalez-Trueba, Laura, Sin, Yuan Yan, Granata, Alessandra, Hamilton, Graham, Lee, Michelle, Boland, Erin, McClure, John D., Lumbreras-Perales, Cristina, Aman, Alisha, Kumar, Apoorva A., Cantini, Marco, Gök, Caglar, Graham, Delyth, Tomono, Yasuko, Anderson, Christopher D., Lu, Yinhui, Smith, Colin, Markus, Hugh S., Abramowicz, Marc, Vilain, Catheline, Al-Shahi Salman, Rustam, Salmeron-Sanchez, Manuel, Hainsworth, Atticus H., Fuller, William, Kadler, Karl E., Bulleid, Neil J., Van Agtmael, Tom

“…Genetic variants in COL4A1 and COL4A2 (encoding collagen IV alpha chain 1/2) occur in genetic and sporadic forms of cerebral small vessel disease (CSVD), a…”
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Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhageResearch in context by Sarah McNeilly, Cameron R. Thomson, Laura Gonzalez-Trueba, Yuan Yan Sin, Alessandra Granata, Graham Hamilton, Michelle Lee, Erin Boland, John D. McClure, Cristina Lumbreras-Perales, Alisha Aman, Apoorva A. Kumar, Marco Cantini, Caglar Gök, Delyth Graham, Yasuko Tomono, Christopher D. Anderson, Yinhui Lu, Colin Smith, Hugh S. Markus, Marc Abramowicz, Catheline Vilain, Rustam Al-Shahi Salman, Manuel Salmeron-Sanchez, Atticus H. Hainsworth, William Fuller, Karl E. Kadler, Neil J. Bulleid, Tom Van Agtmael

“…Background: Genetic variants in COL4A1 and COL4A2 (encoding collagen IV alpha chain 1/2) occur in genetic and sporadic forms of cerebral small vessel disease…”
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A Multi-disciplinary Commentary on Preclinical Research to investigate Vascular Contributions to Dementia by Sri, Sarmi, Greenstein, Adam, Granata, Alessandra, Collcutt, Alex, Jochems, Angela C C, McColl, Barry W, Castro, Blanca Díaz, Webber, Caleb, Reyes, Carmen Arteaga, Hall, Catherine, Lawrence, Catherine B, Hawkes, Cheryl, Pegasiou-Davies, Chrysia-Maria, Gibson, Claire, Crawford, Colin, Smith, Colin, Vivien, Denis, McLean, Fiona H, Wiseman, Frances, Brezzo, Gaia, Lalli, Giovanna, Pritchard, Harry A T, Markus, Hugh S, Bravo-Ferrer, Isabel, Taylor, Jade, Leiper, James, Berwick, Jason, Gan, Jian, Gallacher, John, Moss, Jonathan, Goense, Jozien, McMullan, Letitia, Work, Lorraine, Evans, Lowri, Stringer, Michael S, Ashford, MLJ, Abulfadl, Mohamed, Conlon, Nina, Malhotra, Paresh, Bath, Philip, Canter, Rebecca, Brown, Rosalind, Ince, Selvi, Anderle, Silvia, Young, Simon, Quick, Sophie, Szymkowiak, Stefan, Hill, Steve, Allan, Stuart, Wang, Tao, Quinn, Terry, Procter, Tessa, Farr, Tracy D, Zhao, Xiangjun, Yang, Zhiyuan, Hainsworth, Atticus H, Wardlaw, Joanna M

“…•Different models recapitulate different aspects of human SVD – the right model should be used to answer the right question•Successful translation requires…”
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CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process: Role of the CSN-torsinA complex at the synapse by Granata, Alessandra, Koo, Seong Joo, Haucke, Volker, Schiavo, Giampietro, Warner, Thomas T

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