Disease Activity As a Major Determinant of Quality of Life and Physical Function in Patients With Early Axial Spondyloarthritis

Objective To describe health‐related quality of life (HRQOL) and physical function in patients with early axial spondyloarthritis (SpA) and to assess their associations with disease activity and radiographic damage. Methods This was a cross‐sectional study drawing upon baseline data of axial SpA pat...

Full description

Saved in:

Bibliographic Details
Published in:	Arthritis care & research (2010) Vol. 69; no. 1; pp. 150 - 155
Main Authors:	Fernández‐Carballido, Cristina, Navarro‐Compán, Victoria, Castillo‐Gallego, Concepción, Castro‐Villegas, Maria C., Collantes‐Estévez, Eduardo, de Miguel, Eugenio, Collantes, E., Reina Sofía, H., Carmona, L., Gobbo, M., Mulero, J., Puerta de Hierro, H., Muñoz‐Fernández, S., Infanta Sofía, H., Zarco, P., Alcorcón, F. H., Rivera, J., Gregorio Marañón, H., López Robledillo, J. C., Niño Jesús, H., Castillo Gallego, C., La Paz, H. U., Rosas, J., Santos, G., Marina Baixa, H., Fernández Sueiro, J. L., Pinto Tasende, J., González Díaz de Rabago, E., Juanv, H. U., Montilla, C., Gómez Castro López, S., del Pino Montes, R. J., de Salamanca, H. U., Granados Bautista, I. P., Hernández Sanz, A., Virgen de la Salud, H., Sanz Sanz, J., Fernández Prada, M., Tornero, J., de Guadalajara, H. U., Campos, C., Calvo, J., de Valencia, H. G. U., Juanola, X., Ríos, V., de Bellvitge, H. U., Moreno, E., Rotés, M. I., de San Rafael, H., Ibero, I., Jovaní, V., Martínez Alberola, N., de Elda, H. G. U., Linares, L. F., Moreno Ramos, M. J., Uceda, A., Moreno Martínez, M. J., Beteta, M. D., Virgen de la Arrixaca, H. U., Quevedo, J. C., Rodríguez Lozano, C., Negrín, H. U., Trujillo, E., Bustabad, S., de Canarias, H. U., Román Ivorra, J. A., Muñoz Gil, S., Peset, H. U., Juan Mas, A., Ros Vilamajó, I., Ibáñez Barceló, M., Son Llatzer, H., Gratacós Matmija, J., Moreno Martínez‐Loza, M., Sabadell, H., Almodóvar, R., Fundación Alcorcón, H., Rejón, E., Rodríguez Montero, S., Virgen de Valme, H. U., Ruiz Jimeno, T., Sierrallana, H., Aznar, J. J., Chamizo Carmona, E., Garrido Puñal, N., de Mérida, H., Fernández Dapica, P., Brito Brito, E., Ramón y Cajal, H., Pérez Pampín, E., Clínico, H.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-01-2017
Subjects:	Adult Ankylosing spondylitis Arthritis Back pain C-reactive protein Cross-Sectional Studies Female Health risk assessment Humans Inflammatory diseases Male Mobility Multivariate analysis Pain Quality of Life Rheumatic diseases Spine Spondylarthritis - physiopathology Spondylitis Visual perception
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Objective To describe health‐related quality of life (HRQOL) and physical function in patients with early axial spondyloarthritis (SpA) and to assess their associations with disease activity and radiographic damage. Methods This was a cross‐sectional study drawing upon baseline data of axial SpA patients (Assessment of SpondyloArthritis international Society criteria) from the ESPERANZA cohort. Linear regression analyses were used to evaluate the associations between disease activity and radiographic damage (spine and sacroiliac joints) with HRQOL, physical function, and spinal mobility. Results In total, 259 patients were included. The mean ± SD age was 32.2 ± 6.9 years, disease duration was 13.3 ± 6.8 months, Ankylosing Spondylitis Quality of Life score was 5.9 ± 4.8, Bath Ankylosing Spondylitis Functional Index score was 2.4 ± 2.3, Bath Ankylosing Spondylitis Metrology Index score was 1.4 ± 1.3, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score was 3.8 ± 2.3, C‐reactive protein (CRP) level was 9.7 ± 13.2 mg/liter, and Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI‐s) score was 1.7 ± 1.6. HRQOL was mainly associated with disease activity on univariate analysis (β values for BASDAI 0.646, patient global visual analog scale [VAS] 0.641, night back pain VAS 0.598, physician VAS 0.560, and CRP level 0.275; P < 0.01 for all), whereas the association with radiographic damage was weaker (standardized β for BASRI‐s 0.142; P < 0.05). On multivariate models, HRQOL only remained significantly associated with disease activity (standardized β for BASDAI 0.330; P < 0.01, and physician VAS 0.205 and night back pain VAS 0.210; P = 0.01). Similarly, physical function was associated with disease activity and radiographic damage on univariate analysis, but only with disease activity (BASDAI β 0.466; P < 0.01) on multivariate analysis. However, spinal mobility was associated with radiographic damage in both univariate and multivariate analyses. Conclusion Patients with axial SpA already have impaired quality of life and physical function, albeit mildly, at the beginning of their disease course. Both outcomes are mainly associated with disease activity in these patients.
Bibliography:	The ESPERANZA program is supported by a restricted grant from the Institute Carlos III (FIS project PI13/02034) and Fondos FEDER. Dr. Fernández‐Carballido's work was supported by the Spanish Society of Rheumatology. Members of the ESPERANZA Study Group are shown in the Appendix ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2151-464X 2151-4658
DOI:	10.1002/acr.22908