Search Results - "Granados, Sara"
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Impairment of microvascular endothelial Kir2.1 channels contributes to endothelial dysfunction in human hypertension
Published in American journal of physiology. Heart and circulatory physiology (01-10-2024)“…Hypertension is associated with decreased endothelial function through reduced contributions of nitric oxide (NO). We previously discovered that flow-induced…”
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Cholesterol-Induced Suppression of Endothelial Kir Channels Is a Driver of Impairment of Arteriolar Flow-Induced Vasodilation in Humans
Published in Hypertension (Dallas, Tex. 1979) (01-01-2022)“…Dyslipidemia-induced endothelial dysfunction is an important factor in the progression of cardiovascular disease; however, the underlying mechanisms are…”
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Impairment of endothelial glycocalyx in atherosclerosis and obesity
Published in Current topics in membranes (2023)“…Endothelial glycocalyx is a negatively charged gel-like layer located on the apical surface of endothelial cells. It serves as a selective two-way physical…”
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EGFR exon 20 insertion in lung adenocarcinomas among Hispanics (geno1.2-CLICaP)
Published in Lung cancer (Amsterdam, Netherlands) (01-11-2018)“…•Among 4005 lung adenocarcinoma patients we identified 88 EGFR exon 20 insertions.•Most patients with an exon 20 insertion were female and never-smokers.•36.4%…”
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The Membrane Cholesterol Modulates the Interaction Between 17-βEstradiol and the BK Channel
Published in Frontiers in pharmacology (11-06-2021)“…BK channels are composed by the pore forming α subunit and, in some tissues, is associated with different accessory β subunits. These proteins modify the…”
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Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits
Published in Frontiers in physiology (2014)“…Coded by a single gene (Slo1, KCM) and activated by depolarizing potentials and by a rise in intracellular Ca(2+) concentration, the large conductance voltage-…”
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The molecular nature of the 17β-Estradiol binding site in the voltage- and Ca2+-activated K+ (BK) channel β1 subunit
Published in Scientific reports (10-07-2019)“…The accessory β1 subunit modulates the Ca 2+ - and voltage-activated K + (BK) channel gating properties mainly by increasing its apparent Ca 2+ sensitivity. β1…”
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Activation of BK Channel Contributes to PL-Induced Mesenchymal Stem Cell Migration
Published in Frontiers in physiology (24-03-2020)“…Due to their capacity to proliferate, migrate, and differentiate, mesenchymal stem cells (MSCs) are considered to be good candidates for regenerative medicine…”
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Barriers and Facilitators that Influence on Adopting Healthy Lifestyles in People with Cardiovascular Disease
Published in Investigacion y educacion en enfermeria (01-10-2021)“…To measure lifestyle changes and describe the barriers and facilitators perceived that influence on adopting healthy lifestyles in people with cardiovascular…”
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Cholesterol-induced suppression of Kir2 channels is mediated by decoupling at the inter-subunit interfaces
Published in iScience (20-05-2022)“…Cholesterol is a major regulator of multiple types of ion channels. Although there is increasing information about cholesterol binding sites, the molecular…”
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Abstract 1023: Cholesterol Sensitivity Of A K+ Channel, Kir2.1 Plays A Role In Weight Maintenance, Energy Distribution, And Akt-dependent Mouse Mesenteric Metabolism
Published in Arteriosclerosis, thrombosis, and vascular biology (01-05-2024)“…Abstract only Background: Inwardly Rectifying Potassium Channel 2.1 (Kir2.1) plays a role in the maintenance of membrane potential and is strongly suppressed…”
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Abstract 15088: Cholesterol-Induced Suppression of Kir2.1 Contributes to the Development of Atherosclerosis
Published in Circulation (New York, N.Y.) (08-11-2022)“…IntroductionOur recent studies demonstrated that cholesterol sensitivity of inwardly-rectifying K+ channels (Kir2.1) contributes to the impairment of…”
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Cholesterol sensitivity of a ubiquitous K+ channel, Kir2.1 plays a role in weight gain and healthspan in mice
Published in Physiology (Bethesda, Md.) (01-05-2023)“…Abstract only Background: Inwardly Rectifying Potassium Channel 2.1 (Kir2.1) a ubiquitously expressed K+ channel with the main functions of the maintenance of…”
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Water and poverty in two Colombian watersheds
Published in Water alternatives (01-02-2009)“…Watersheds, especially in the developing world, are increasingly being managed for both environmental conservation and poverty alleviation. How complementary…”
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17β-Estradiol Binds and Modulates BK Channel through its β1 Auxiliary Subunit
Published in Biophysical journal (16-02-2016)Get full text
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Barreras y facilitadores que influyen en la adopción de estilos de vida saludables en personas con enfermedad cardiovascular
Published in Investigación y educación en enfermería (01-09-2021)“…Objetivo. Medir el cambio en el estilo de vida y describir las barreras y los facilitadores percibidos que influyen en la adopción de un estilo de vida…”
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Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits
Published in Frontiers in physiology (10-10-2014)Get full text
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Hierarchical architecture for motion and depth estimations based on color cues
Published in Journal of real-time image processing (01-06-2015)“…This work presents an FPGA implementation of a highly parallel architecture for the motion and disparity estimations of color images. Our system implements the…”
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The molecular nature of the 17β-Estradiol binding site in the voltage- and Ca 2+ -activated K + (BK) channel β1 subunit
Published in Scientific reports (10-07-2019)“…The accessory β1 subunit modulates the Ca - and voltage-activated K (BK) channel gating properties mainly by increasing its apparent Ca sensitivity. β1 plays…”
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