Search Results - "Grana, X"

Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs) by Graña, X, Reddy, E P

“…All eukaryotic cells possess similar mechanisms to regulate the progression of the cell cycle. However, higher eukaryotes have evolved to respond to a large…”
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Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth by Graña, X, Garriga, J, Mayol, X

“…The retinoblastoma family of proteins, also known as pocket proteins, includes the product of the retinoblastoma susceptibility gene and the functionally and…”
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PITALRE, a Nuclear CDC2-Related Protein Kinase that Phosphorylates the Retinoblastoma Protein in vitro by Grana, X., De Luca, A., Sang, N., Fu, Y., Claudio, P. P., Rosenblatt, J., Morgan, D. O., Giordano, A.

“…Members of the cell division cycle 2 (CDC2) family of kinases play a pivotal role in the regulation of the eukaryotic cell cycle. In this communication, we…”
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Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130 by Mayol, X, Garriga, J, Graña, X

“…The retinoblastoma-related protein p130 is a putative negative regulator of cell proliferation in mammalian cells. In this study, p130 is shown to exist in…”
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The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity by Calbó, J, Serna, C, Garriga, J, Graña, X, Mazo, A

“…Restitution of lost tumor-suppressor activities may be a promising strategy to target specifically cancer cells. However, the action of ectopically expressed…”
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G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4 by Mayol, X, Garriga, J, Graña, X

“…During the transition from G1 to G0, p130 undergoes a specific phosphorylation event-leading to p130-form 2- that is mediated by a kinase/s other than the…”
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Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain by Mayol, X, Graña, X, Baldi, A, Sang, N, Hu, Q, Giordano, A

“…The product of the retinoblastoma tumor suppressor gene (pRb) and p107 share a high degree of structural homology in the pocket region, which is thought to…”
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The Ability of Positive Transcription Elongation Factor b To Transactivate Human Immunodeficiency Virus Transcription Depends on a Functional Kinase Domain, Cyclin T1, and Tat by Fujinaga, K, Cujec, T P, Peng, J, Garriga, J, Price, D H, Graña, X, Peterlin, B M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Upregulation of cyclin T1/CDK9 complexes during T cell activation by GARRIGA, J, JUNMIN PENG, PARRENO, M, PRICE, D. H, HENDERSON, E. E, GRANA, X

“…Cyclin T1 has been identified recently as a regulatory subunit of CDK9 and as a component of the transcription elongation factor P-TEFb. Cyclin T1/CDK9…”
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Transcription of Histone H4, H3, and H1 Cell Cycle Genes: Promoter Factor HiNF-D Contains CDC2, Cyclin A, and an RB-Related Protein by van Wijnen, Andre J., Aziz, Farah, Grana, Xavier, De Luca, Antonio, Desai, Rajesh K., Jaarsveld, Karen, Last, Thomas J., Soprano, Kenneth, Giordano, Antonio, Lian, Jane B., Stein, Janet L., Stein, Gary S.

“…Cell cycle-controlled human histone genes are coordinately expressed during S phase, and transcriptional regulation involves a series of trans-acting factors…”
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E1A modulates phosphorylation of p130 and p107 by differentially regulating the activity of G1/S cyclin/CDK complexes by PARRENO, Matilde, GARRIGA, Judit, LIMON, Ana, ALBRECHT, Jeffrey H, GRANA, Xavier

“…We have previously shown that the adenoviral 12S E1A protein modulates the phosphorylation status of p130 and p107 without apparent changes in the cell cycle…”
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Cellular control of gene expression by T-type cyclin/CDK9 complexes by Garriga, Judit, Graña, Xavier

“…The family of Cyclin-Dependent Kinases (CDKs) can be subdivided into two major functional groups based on their roles in cell cycle and/or transcriptional…”
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Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells by SALA, A, NICOLAIDES, N. C, ENGELHARD, A, BELLON, T, LAWE, D. C, FARNOLD, A, GRANA, X, GIORDANO, A, CALABRETTA, B

“…The mammalian nuclear protein E2F-1 has recently been cloned based on its ability to bind the retinoblastoma protein. To determine whether E2F-1 plays a role…”
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The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19 by Yeung, R S, Bell, D W, Testa, J R, Mayol, X, Baldi, A, Graña, X, Klinga-Levan, K, Knudson, A G, Giordano, A

“…A retinoblastoma-related human gene, referred to as RB2, has been cloned based on sequence homology of the E1A-binding domain of the retinoblastoma gene…”
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Introduction: Current Themes on Cell Cycle and Cancer by Grana, X.

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Monographs editor by Grana, X.

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E1A Blocks Hyperphosphorylation of p130 and p107 without Affecting the Phosphorylation Status of the Retinoblastoma Protein by Parreño, M, Garriga, J, Limón, A, Mayol, X, Beck, Jr, G R, Moran, E, Graña, X

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in Cancer by Kurimchak, Alison, Graña, Xavier

“…Protein Phosphatase 2A (PP2A) consists of a collection of heterotrimeric serine/threonine phosphatase holoenzymes that play multiple roles in cell signaling…”
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An E2F binding sequence negatively regulates the response of the insulin-like growth factor 1 (IGF-I) promoter to simian virus 40T antigen and to serum by Porcu, P, Graña, X, Li, S, Swantek, J, De Luca, A, Giordano, A, Baserga, R

“…The promoter of the Insulin-like growth factor I (IGF-I) gene is activated by the Simian Virus 40 large T antigen (SVLT), and one of the elements responding to…”
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Isolation and characterization of cofactor-independent phosphoglycerate mutase gene from maize by Pérez de la Ossa, P, Graña, X, Ruiz-Lozano, P, Climent, F

“…The isolation and characterization of cofactor-independent phosphoglycerate mutase gene from maize (Zea mays) is here reported. This gene sequence constitutes…”
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