Search Results - "Gramajo, H"

Transcriptional regulation of fatty acid biosynthesis in mycobacteria by Mondino, S., Gago, G., Gramajo, H.

“…Summary The main purpose of our study is to understand how mycobacteria exert control over the biosynthesis of their membrane lipids and find out the key…”
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Light Modulates Important Pathogenic Determinants and Virulence in ESKAPE Pathogens Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus by Tuttobene, M R, Pérez, J F, Pavesi, E S, Perez Mora, B, Biancotti, D, Cribb, P, Altilio, M, Müller, G L, Gramajo, H, Tamagno, G, Ramírez, M S, Diacovich, L, Mussi, M A

“…Light sensing has been extensively characterized in the human pathogen at environmental temperatures. However, the influence of light on the physiology and…”
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Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli by Pfeifer, Blaine A., Admiraal, Suzanne J., Gramajo, Hugo, Cane, David E., Khosla, Chaitan

“…The macrocyclic core of the antibiotic erythromycin, 6-deoxyerythronolide B (6dEB), is a complex natural product synthesized by the soil bacterium…”
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Transcriptional regulation of lipid homeostasis in mycobacteria by Salzman, V, Mondino, S, Sala, C, Cole, S.T, Gago, G, Gramajo, H

“…Mycolic acids are major components of the cell envelope of mycobacteria, such as Mycobacterium tuberculosis, and play an important role in its architecture,…”
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Genetic and biochemical characterization of the α and β components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2) by RODRIGUEZ, E, GRAMAJO, H

“…Two genes, accA1 and accA2, with nearly identical nucleotide sequences were cloned from Streptomyces coelicolor A3(2). The deduced amino acid sequences of the…”
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Role of an Essential Acyl Coenzyme A Carboxylase in the Primary and Secondary Metabolism of Streptomyces coelicolor A3(2) by RODRIGUEZ, E, BANCHIO, C, DIACOVICH, L, BIBB, M. J, GRAMAJO, H

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A Stationary-Phase Acyl-Coenzyme A Synthetase of Streptomyces coelicolor A3(2) Is Necessary for the Normal Onset of Antibiotic Production by BANCHIO, C, GRAMAJO, H

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Transcriptional regulation of the redD transcriptional activator gene accounts for growth-phase-dependent production of the antibiotic undecylprodigiosin in Streptomyces coelicolor A3(2) by Takano, E, Gramajo, H C, Strauch, E, Andres, N, White, J, Bibb, M J

“…Transcription of redD, the activator gene required for production of the red-pigmented antibiotic undecylprodigiosin by Streptomyces coelicolor A3(2), showed a…”
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Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated by Gramajo, H C, Takano, E, Bibb, M J

“…Production of actinorhodin, a polyketide antibiotic made by Streptomyces coelicolor A3(2), normally occurs only in stationary-phase cultures. S1 nuclease…”
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Novel escherichia coli strain allows efficient recombinant protein production using lactose as inducer by Menzella, Hugo G., Ceccarelli, Eduardo A., Gramajo, Hugo C.

“…An important characteristic of promoters used in recombinant protein production in Escherichi coli is their inducibility in a simple and cost‐effective manner…”
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Purification and characterization of the acyl carrier protein of the Streptomyces glaucescens tetracenomycin C polyketide synthase by BEN SHEN, SUMMERS, R. G, GRAMAJO, H, BIBB, M. J, HUTCHINSON, C. R

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Medium- and long-chain fatty acid uptake and utilization by Streptomyces coelicolor A3(2): first characterization of a Gram-positive bacterial system by Banchio, C, Gramajo, H.C

“…The first characterization of fatty acid uptake in a Gram-positive bacterium is reported. Streptomyces coelicolor A3(2) utilizes fatty acids of different chain…”
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Overproduction and localization of components of the polyketide synthase of Streptomyces glaucescens involved in the production of the antibiotic tetracenomycin C by GRAMAJO, H. C, WHITE, J, HUTCHINSON, C. R, BIBB, M. J

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Recombinant Protein Production in High Cell Density Cultures of Escherichia coli with Galactose as a Gratuitous Inducer by Menzella, Hugo G., Gramajo, Hugo C.

“…A new expression system was developed by introducing two major modifications into the genome of Escherichia coli: a deletion in the gal operon (ΔgalEKT) to…”
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Characterization of stationary-phase proteins in Streptomyces coelicolor A3(2) by Orsaria, Lelia, Paoletti, Luciana, Gramajo, Hugo C

“…Abstract Using two-dimensional (2-D) gel electrophoresis, we have analyzed the continuous changes in protein profiles, from exponential to late stationary…”
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De novo fatty acid synthesis is required for establishment of cell type‐specific gene transcription during sporulation in Bacillus subtilis by Schujman, Gustavo E., Grau, Roberto, Gramajo, Hugo C., Ornella, Leonardo, De Mendoza, Diego

“…A hallmark of sporulation of Bacillus subtilis is the formation of two distinct cells by an asymmetric septum. The developmental programme of these two cells…”
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The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation by Carvalho, Ruby, Reid, Ralph, Viswanathan, Nina, Gramajo, Hugo, Julien, Bryan

“…Disorazoles are polyketides produced by the myxobacterium Sorangium cellulosum So ce12. Their mode of action is to inhibit tubulin polymerization and…”
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Biochemical and Structural Characterization of an Essential Acyl Coenzyme A Carboxylase from Mycobacterium tuberculosis by Gago, Gabriela, Kurth, Daniel, Diacovich, Lautaro, Tsai, Shiou-Chuan, Gramajo, Hugo

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Production of the Potent Antibacterial Polyketide Erythromycin C in Escherichia coli by Peirú, Salvador, Menzella, Hugo G, Rodríguez, Eduardo, Carney, John, Gramajo, Hugo

“…An Escherichia coli strain capable of producing the potent antibiotic erythromycin C (Ery C) was developed by expressing 17 new heterologous genes in a…”
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Structure-Based Inhibitor Design of AccD5, an Essential Acyl-CoA Carboxylase Carboxyltransferase Domain of Mycobacterium tuberculosis by Lin, Ting-Wan, Melgar, Melrose M., Kurth, Daniel, Swamidass, S. Joshua, Purdon, John, Tseng, Teresa, Gago, Gabriela, Baldi, Pierre, Gramajo, Hugo, Tsai, Shiou-Chuan

“…Mycolic acids and multimethyl-branched fatty acids are found uniquely in the cell envelope of pathogenic mycobacteria. These unusually long fatty acids are…”
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