Search Results - "Gralla, E B"

Bcl-2 Inhibition of Neural Death: Decreased Generation of Reactive Oxygen Species by Kane, Darci J., Sarafian, Theodore A., Anton, Rein, Hahn, Hejin, Gralla, Edith Butler, Valentine, Joan Selverstone, Örd, Tõnis, Bredesen, Dale E.

“…The proto-oncogene bcl-2 inhibits apoptotic and necrotic neural cell death. Expression of Bcl-2 in the GT1-7 neural cell line prevented death as a result of…”
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Yeast and Mammalian Metallothioneins Functionally Substitute for Yeast Copper-Zinc Superoxide Dismutase by Tamai, Katherine T., Gralla, Edith B., Ellerby, Lisa M., Valentine, Joan S., Thiele, Dennis J.

“…Copper-zinc superoxide dismutase catalyzes the disproportionation of superoxide anion to hydrogen peroxide and dioxygen and is thought to play an important…”
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Delivering Copper Inside Yeast and Human Cells by Valentine, Joan Selverstone, Gralla, Edith Butler

“…Two recent reports further understanding of the transport of normally toxic copper through cellular matter. One report discusses the mechanism of in vivo…”
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Mutations Associated with Amyotrophic Lateral Sclerosis Convert Superoxide Dismutase from an Antiapoptotic Gene to a Proapoptotic Gene: Studies in Yeast and Neural Cells by Rabizadeh, Shahrooz, Gralla, Edith Butler, Borchelt, David R., Gwinn, Ryder, Valentine, Joan Selverstone, Sisodia, Sangram, Wong, Philip, Lee, Michael, Hahn, Hejin, Bredesen, Dale E.

“…Familial amyotrophic lateral sclerosis (FALS) is associated with mutations in SOD1, the gene encoding copper/zinc superoxide dismutase (CuZnSOD). However, the…”
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Null mutants of Saccharomyces cerevisiae Cu,Zn superoxide dismutase: characterization and spontaneous mutation rates by Gralla, E.B. (University of California, Los Angeles, Los Angeles, CA), Valentine, J.S

“…Deletion-replacement mutations of the Saccharomyces cerevisiae Cu, Zn superoxide dismutase gene were constructed. They were exquisitely sensitive to redox…”
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Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation by RAMOTAR, D, POPOFF, S. C, GRALLA, E. B, DEMPLE, B

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The metal binding properties of the zinc site of yeast copper-zinc superoxide dismutase: implications for amyotrophic lateral sclerosis by Lyons, T J, Nersissian, A, Huang, H, Yeom, H, Nishida, C R, Graden, J A, Gralla, E B, Valentine, J S

“…We have investigated factors that influence the properties of the zinc binding site in yeast copper-zinc superoxide dismutase (CuZnSOD). The properties of…”
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ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene by GRALLA, E. B, THIELE, D. J, SILAR, P, VALENTINE, J. S

“…Copper, zinc superoxide dismutase (SOD1 gene product) (superoxide:superoxide oxidoreductase, EC 1.15.1.1) is a copper-containing enzyme that functions to…”
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Mutations in Copper-Zinc Superoxide Dismutase that Cause Amyotrophic Lateral Sclerosis Alter the Zinc Binding Site and the Redox Behavior of the Protein by Lyons, Thomas J., Liu, Hongbin, Goto, Joy J., Nersissian, Aram, Roe, James A., Graden, Janet A., Cafe, Carla, Ellerby, Lisa M., Bredesen, Dale E., Gralla, Edith Butler, Valentine, Joan Selverstone

“…A series of mutant human and yeast copper-zinc superoxide dismutases has been prepared, with mutations corresponding to those found in familial amyotrophic…”
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Subunit asymmetry in the three‐dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis by Eisenberg, David, Hart, P. John, Liu, Hongbin, Pellegrini, Matteo, Nersissian, Aram M., Gralla, Edith B., Valentine, Joan S.

“…The X‐ray crystal structure of a human copper/zinc superoxide dismutase mutant (G37R CuZnSOD) found in some patients with the inherited form of Lou Gehrig's…”
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The copper, zinc-superoxide dismutase gene of Saccharomyces cerevisiae: cloning, sequencing, and biological activity by Bermingham-McDonogh, O, Gralla, E.B, Valentine, J.S

“…The gene for copper, zinc-superoxide dismutase (Cu,Zn-SOD; EC 1.15.1.1) from the yeast Saccharomyces cerevisiae has been cloned, sequenced, and shown to have…”
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Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis by Wiedau-Pazos, Martina, Goto, Joy J., Rabizadeh, Shahrooz, Gralla, Edith B., Roe, James A., Lee, Michael K., Valentine, Joan S., Bredesen, Dale E.

“…A subset of individuals with familial amyotrophic lateral sclerosis (FALS) possesses dominantly inherited mutations in the gene that encodes copper-zinc…”
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Yeast lacking superoxide dismutase. Isolation of genetic suppressors by Liu, X.F. (The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD), Elashvili, I, Gralla, E.B, Valentin, J.S, Lapinskas, P, Culotta, V.C

“…Null mutants of superoxide dismutase (SOD) in Saccharomyces cerevisiae are associated with a number of biochemical defects. In addition to being hypersensitive…”
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Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo by Longo, V.D. (University of California, Los Angeles.), Gralla, E.B, Valentine, J.S

“…Yeast lacking copper-zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (SOD), catalase T, or metallothionein were studied using long term…”
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Molecular genetics of superoxide dismutases in yeasts and related fungi by Gralla, E B, Kosman, D J

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Yeast Lacking Superoxide Dismutase(s) Show Elevated Levels of “Free Iron” as Measured by Whole Cell Electron Paramagnetic Resonance by Srinivasan, Chandra, Liba, Amir, Imlay, James A., Valentine, Joan Selverstone, Gralla, Edith Butler

“…A current hypothesis explaining the toxicity of superoxide anion in vivo is that it oxidizes exposed [4Fe-4S] clusters in certain vulnerable enzymes causing…”
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Mitochondrial Superoxide Decreases Yeast Survival in Stationary Phase by Longo, Valter D., Liou, Lee-Loung, Valentine, Joan Selverstone, Gralla, Edith Butler

“…Yeast lacking mitochondrial superoxide dismutase (MnSOD) display shortened stationary-phase survival and provide a good model system for studying mitochondrial…”
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Loss of in Vitro Metal Ion Binding Specificity in Mutant Copper-Zinc Superoxide Dismutases Associated with Familial Amyotrophic Lateral Sclerosis by Goto, Joy J., Zhu, Haining, Sanchez, Raylene J., Nersissian, Aram, Gralla, Edith Butler, Valentine, Joan Selverstone, Cabelli, Diane E.

“…The presence of the copper ion at the active site of human wild type copper-zinc superoxide dismutase (CuZnSOD) is essential to its ability to catalyze the…”
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Human Bcl-2 Reverses Survival Defects in Yeast Lacking Superoxide Dismutase and Delays Death of Wild-Type Yeast by Longo, Valter D., Ellerby, Lisa M., Bredesen, Dale E., Valentine, Joan S., Gralla, Edith B.

“…We expressed the human anti-apoptotic protein, Bcl-2, in Saccharomyces cerevisiae to investigate its effects on antioxidant protection and stationary phase…”
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The dark side of dioxygen biochemistry by Valentine, Joan Selverstone, Wertz, Diana L, Lyons, Thomas J, Liou, Lee-Loung, Goto, Joy J, Gralla, Edith Butler

“…The cellular biochemistry of dioxygen is Janus-faced. The good side includes numerous enzyme-catalyzed reactions of dioxygen that occur in respiration and…”
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