Search Results - "Gralinski, M."

Investigation of mechanism of drug‐induced cardiac injury and torsades de pointes in cynomolgus monkeys by Misner, DL, Frantz, C, Guo, L, Gralinski, MR, Senese, PB, Ly, J, Albassam, M, Kolaja, KL

“…BACKGROUND AND PURPOSE Drug candidates must be thoroughly investigated for their potential cardiac side effects. During the course of routine toxicological…”
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Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart by Gralinski, M R, Black, S C, Kilgore, K S, Chou, A Y, McCormack, J G, Lucchesi, B R

“…The aim was to examine the putative cardioprotective effects of the novel antianginal agent, ranolazine, using an isolated rabbit heart model of ischaemia and…”
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Localization of cyclooxygenase isozymes in cardiovascular tissues of dogs treated with naproxen by Stanfield, Kristina M., Khan, K.Nasir, Gralinski, Michael R.

“…Prostaglandins have diverse roles in the cardiovascular system mediating both physiologic and inflammatory responses. Two cyclooxygenase isoforms,…”
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Effects of Heparin and N-Acetyl Heparin on Ischemia/Reperfusion-Induced Alterations in Myocardial Function in the Rabbit Isolated Heart by Friedrichs, Gregory S, Kilgore, Kenneth S, Manley, Peter J, Gralinski, Michael R, Lucchesi, Benedict R

“…Evidence is presented that heparin pretreatment produces protective effects on myocardial tissue distinct from its anticoagulant activity. The present study…”
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Cardioprotective effects of heparin or N-acetylheparin in an in vivo model of myocardial ischaemic and reperfusion injury by Black, S C, Gralinski, M R, Friedrichs, G S, Kilgore, K S, Driscoll, E M, Lucchesi, B R

“…The aim was to determine if either heparin or N-acetylheparin could reduce the extent of myocardial injury resulting from 90 min of coronary artery occlusion…”
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Effects of Troglitazone and Pioglitazone on Cytokine-Mediated Endothelial Cell Proliferation In Vitro by Gralinski, Michael R, Rowse, Paul E, Breider, Michael A

“…We examined whether troglitazone and pioglitazone, antidiabetic thiazolidinediones, would directly induce endothelial cell proliferation or influence…”
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The assessment of potential for QT interval prolongation with new pharmaceuticals: Impact on drug development by Gralinski, Michael R

“…Few examinations of a single physiological variable can end the development of a putative new pharmaceutical. Prolongation of the electrocardiographic QT…”
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Effect of ranolazine on infarct size in a canine model of regional myocardial ischemia/reperfusion by Black, S C, Gralinski, M R, McCormack, J G, Driscoll, E M, Lucchesi, B R

“…We assessed ranolazine's potential to reduce myocardial injury resulting from 90-min occlusion and 18-h reperfusion of left circumflex coronary artery (LCX) in…”
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MS-551 protects against ventricular fibrillation in a chronic canine model of sudden cardiac death by Friedrichs, G S, Chi, L, Gralinski, M R, Black, S C, Basler, G C, Mu, D X, Pewitt, S R, Johnson, C R, Lucchesi, B R

“…We studied the electrophysiologic and antifibrillatory properties of MS-551 (1,3-dimethyl-6-((2-[N-hydroxy-ethyl)-3-(4-nitrophenyl) propylamino] ethylamino)…”
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Reviparin-Sodium Prevents Complement-Mediated Myocardial Injury in the Isolated Rabbit Heart by Park, James L, Tanhehco, Elaine J, Kilgore, Kenneth S, Gralinski, Michael R, Lucchesi, Benedict R

“…The cytoprotective action of reviparin-sodium (LU-47311; Clivarin), a low-molecular-weight heparin, was examined in an ex vivo model of complement-mediated…”
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Heat stress protects the perfused rabbit heart from complement-mediated injury by Gralinski, M R, Black, S C, Stancato, L F, Kilgore, K S, Campau, P A, Park, J L, Ozeck, M J, Pratt, W B, Lucchesi, B R

“…We determined if heat stress induction of heat shock protein (HSP) 70 modulates complement activation in an experimental model of xenograft rejection. Male New…”
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Selective inhibition of the alternative complement pathway by sCR1[desLHR-a]protects the rabbit isolated heart from human complement-mediated damage by Gralinski, Michael R., Wiater, Bridget C., Assenmacher, Amy N., Lucchesi, Benedict R.

“…Evidence is presented that treatment with a selective inhibitor of the alternative complement pathway, sCR1[desLHR-A], protects the ex vivo perfused rabbit…”
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LU 51198, a highly sulfated, low-molecular-weight heparin derivative, prevents complement-mediated myocardial injury in the perfused rabbit heart by Gralinski, M R, Park, J L, Ozeck, M A, Wiater, B C, Lucchesi, B R

“…Evidence is presented that treatment with a highly sulfated low-molecular-weight heparin fraction, LU 51198, protects the ex vivo perfused rabbit heart from…”
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A cardiovascular safety assessment paradigm for the early identification of proarrhythmic and torsadagenic compounds by Misner, Dinah L., Frantz, C., Meierhenry, E., Fielden, M., Guo, L., Ly, J., Uppal, H., Rotstein, D., Gralinski, M., Senese, P., Albassam, M., Chanda, Sushmita, Platz, Stefan, Kolaja, K.

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EVALUATION OF THE CARDIAC ELECTROPHYSIOLOGIC EFFECTS OF INTRAVENOUS AMIODARONF. FORMULATIONS: 93 by Cushing, D J, Lipicky, R, Kowey, P, Kudcnchuk, P, Cooper, W, Gralinski, M

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Internship at Siemens by Gralinski, Shawn M

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The dog's role in the preclinical assessment of QT interval prolongation by GRALINSKI, Michael R

“…During the development of a new therapeutic, few pharmacodyamic outcomes currently receive as much scrutiny as the effect of a potential medication on the…”
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Effects of supervisor style and empathy upon counselor learning by Payne, Paul A, Gralinski, Dennis M

“…Examined effects of supervisor style (techniques and counseling types) and supervisor empathy upon counselor learning of empathy in a supervision analogue. 3…”
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Effects of Supervisor Style and Empathy on Counselor Perceptions in Simulated Counseling by Payne, Paul A, Gralinski, Dennis M

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Outer Cortical Necrosis Associated With Renal Artery Constriction in the Kidney of a Dog by Senese, Peter B., Gralinski, Michael R., Khan, K. Nasir

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