Search Results - "Gralinski, Lisa E"

Return of the Coronavirus: 2019-nCoV by Gralinski, Lisa E, Menachery, Vineet D

“…The emergence of a novel coronavirus (2019-nCoV) has awakened the echoes of SARS-CoV from nearly two decades ago. Yet, with technological advances and…”
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Molecular pathology of emerging coronavirus infections by Gralinski, Lisa E, Baric, Ralph S

“…Respiratory viruses can cause a wide spectrum of pulmonary diseases, ranging from mild, upper respiratory tract infections to severe and life‐threatening lower…”
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Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis by Gralinski, Lisa E, Sheahan, Timothy P, Morrison, Thomas E, Menachery, Vineet D, Jensen, Kara, Leist, Sarah R, Whitmore, Alan, Heise, Mark T, Baric, Ralph S

“…Acute respiratory distress syndrome (ARDS) is immune-driven pathologies that are observed in severe cases of severe acute respiratory syndrome coronavirus…”
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Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses by Sheahan, Timothy P, Sims, Amy C, Graham, Rachel L, Menachery, Vineet D, Gralinski, Lisa E, Case, James B, Leist, Sarah R, Pyrc, Krzysztof, Feng, Joy Y, Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O, Mackman, Richard L, Spahn, Jamie E, Palmiotti, Christopher A, Siegel, Dustin, Ray, Adrian S, Cihlar, Tomas, Jordan, Robert, Denison, Mark R, Baric, Ralph S

“…Emerging viral infections are difficult to control because heterogeneous members periodically cycle in and out of humans and zoonotic hosts, complicating the…”
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A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence by Menachery, Vineet D, Yount, Boyd L, Debbink, Kari, Agnihothram, Sudhakar, Gralinski, Lisa E, Plante, Jessica A, Graham, Rachel L, Scobey, Trevor, Ge, Xing-Yi, Donaldson, Eric F, Randell, Scott H, Lanzavecchia, Antonio, Marasco, Wayne A, Shi, Zhengli-Li, Baric, Ralph S

“…Ralph Baric, Vineet Menachery and colleagues characterize a SARS-like coronavirus circulating in Chinese horseshoe bats to determine its potential to infect…”
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Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection by Menachery, Vineet D, Dinnon, 3rd, Kenneth H, Yount, Jr, Boyd L, McAnarney, Eileen T, Gralinski, Lisa E, Hale, Andrew, Graham, Rachel L, Scobey, Trevor, Anthony, Simon J, Wang, Lingshu, Graham, Barney, Randell, Scott H, Lipkin, W Ian, Baric, Ralph S

“…Traditionally, the emergence of coronaviruses (CoVs) has been attributed to a gain in receptor binding in a new host. Our previous work with severe acute…”
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SARS-like WIV1-CoV poised for human emergence by Menachery, Vineet D., Yount, Boyd L., Sims, Amy C., Debbink, Kari, Agnihothram, Sudhakar S., Gralinski, Lisa E., Graham, Rachel L., Scobey, Trevor, Plante, Jessica A., Royal, Scott R., Swanstrom, Jesica, Sheahan, Timothy P., Pickles, Raymond J., Corti, Davide, Randell, Scott H., Lanzavecchia, Antonio, Marasco, Wayne A., Baric, Ralph S.

“…Outbreaks from zoonotic sources represent a threat to both human disease as well as the global economy. Despite a wealth of metagenomics studies,methods to…”
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Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity by Menachery, Vineet D, Yount, Jr, Boyd L, Josset, Laurence, Gralinski, Lisa E, Scobey, Trevor, Agnihothram, Sudhakar, Katze, Michael G, Baric, Ralph S

“…The sudden emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and, more recently, Middle Eastern respiratory syndrome CoV (MERS-CoV)…”
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Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus by Josset, Laurence, Menachery, Vineet D, Gralinski, Lisa E, Agnihothram, Sudhakar, Sova, Pavel, Carter, Victoria S, Yount, Boyd L, Graham, Rachel L, Baric, Ralph S, Katze, Michael G

“…A novel human coronavirus (HCoV-EMC) was recently identified in the Middle East as the causative agent of a severe acute respiratory syndrome (SARS) resembling…”
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MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis by Menachery, Vineet D, Mitchell, Hugh D, Cockrell, Adam S, Gralinski, Lisa E, Yount, Jr, Boyd L, Graham, Rachel L, McAnarney, Eileen T, Douglas, Madeline G, Scobey, Trevor, Beall, Anne, Dinnon, 3rd, Kenneth, Kocher, Jacob F, Hale, Andrew E, Stratton, Kelly G, Waters, Katrina M, Baric, Ralph S

“…While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and…”
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Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross by Gralinski, Lisa E, Ferris, Martin T, Aylor, David L, Whitmore, Alan C, Green, Richard, Frieman, Matthew B, Deming, Damon, Menachery, Vineet D, Miller, Darla R, Buus, Ryan J, Bell, Timothy A, Churchill, Gary A, Threadgill, David W, Katze, Michael G, McMillan, Leonard, Valdar, William, Heise, Mark T, Pardo-Manuel de Villena, Fernando, Baric, Ralph S

“…New systems genetics approaches are needed to rapidly identify host genes and genetic networks that regulate complex disease outcomes. Using genetically…”
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Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury by Gralinski, Lisa E, Bankhead, 3rd, Armand, Jeng, Sophia, Menachery, Vineet D, Proll, Sean, Belisle, Sarah E, Matzke, Melissa, Webb-Robertson, Bobbie-Jo M, Luna, Maria L, Shukla, Anil K, Ferris, Martin T, Bolles, Meagan, Chang, Jean, Aicher, Lauri, Waters, Katrina M, Smith, Richard D, Metz, Thomas O, Law, G Lynn, Katze, Michael G, McWeeney, Shannon, Baric, Ralph S

“…Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and…”
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New Metrics for Evaluating Viral Respiratory Pathogenesis by Menachery, Vineet D, Gralinski, Lisa E, Baric, Ralph S, Ferris, Martin T

“…Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus…”
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Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses by Agnihothram, Sudhakar, Gopal, Robin, Yount, Boyd L., Donaldson, Eric F., Menachery, Vineet D., Graham, Rachel L., Scobey, Trevor D., Gralinski, Lisa E., Denison, Mark R., Zambon, Maria, Baric, Ralph S.

“…Background. Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012, causing severe acute respiratory disease and pneumonia, with 44% mortality…”
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Modeling host genetic regulation of influenza pathogenesis in the collaborative cross by Ferris, Martin T, Aylor, David L, Bottomly, Daniel, Whitmore, Alan C, Aicher, Lauri D, Bell, Timothy A, Bradel-Tretheway, Birgit, Bryan, Janine T, Buus, Ryan J, Gralinski, Lisa E, Haagmans, Bart L, McMillan, Leonard, Miller, Darla R, Rosenzweig, Elizabeth, Valdar, William, Wang, Jeremy, Churchill, Gary A, Threadgill, David W, McWeeney, Shannon K, Katze, Michael G, Pardo-Manuel de Villena, Fernando, Baric, Ralph S, Heise, Mark T

“…Genetic variation contributes to host responses and outcomes following infection by influenza A virus or other viral infections. Yet narrow windows of disease…”
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The Mouse Universal Genotyping Array: From Substrains to Subspecies by Morgan, Andrew P, Fu, Chen-Ping, Kao, Chia-Yu, Welsh, Catherine E, Didion, John P, Yadgary, Liran, Hyacinth, Leeanna, Ferris, Martin T, Bell, Timothy A, Miller, Darla R, Giusti-Rodriguez, Paola, Nonneman, Randal J, Cook, Kevin D, Whitmire, Jason K, Gralinski, Lisa E, Keller, Mark, Attie, Alan D, Churchill, Gary A, Petkov, Petko, Sullivan, Patrick F, Brennan, Jennifer R, McMillan, Leonard, Pardo-Manuel de Villena, Fernando

“…Genotyping microarrays are an important resource for genetic mapping, population genetics, and monitoring of the genetic integrity of laboratory stocks. We…”
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Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice by Graham, Jessica B, Swarts, Jessica L, Leist, Sarah R, Schäfer, Alexandra, Menachery, Vineet D, Gralinski, Lisa E, Jeng, Sophia, Miller, Darla R, Mooney, Michael A, McWeeney, Shannon K, Ferris, Martin T, Pardo-Manuel de Villena, Fernando, Heise, Mark T, Baric, Ralph S, Lund, Jennifer M

“…The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete understanding of…”
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Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice by Gralinski, Lisa E, Menachery, Vineet D, Morgan, Andrew P, Totura, Allison L, Beall, Anne, Kocher, Jacob, Plante, Jessica, Harrison-Shostak, D Corinne, Schäfer, Alexandra, Pardo-Manuel de Villena, Fernando, Ferris, Martin T, Baric, Ralph S

“…Host genetic variation is known to contribute to differential pathogenesis following infection. Mouse models allow direct assessment of host genetic factors…”
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Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross by Noll, Kelsey E., Whitmore, Alan C., West, Ande, McCarthy, Mary K., Morrison, Clayton R., Plante, Kenneth S., Hampton, Brea K., Kollmus, Heike, Pilzner, Carolin, Leist, Sarah R., Gralinski, Lisa E., Menachery, Vineet D., Schäfer, Alexandra, Miller, Darla, Shaw, Ginger, Mooney, Michael, McWeeney, Shannon, Pardo-Manuel de Villena, Fernando, Schughart, Klaus, Morrison, Thomas E., Baric, Ralph S., Ferris, Martin T., Heise, Mark T.

“…Host genetic factors play a fundamental role in regulating humoral immunity to viral infection, including influenza A virus (IAV). Here, we utilize the…”
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Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury by Sims, Amy C, Mitchell, Hugh D, Gralinski, Lisa E, Kyle, Jennifer E, Burnum-Johnson, Kristin E, Lam, Mariam, Fulcher, M Leslie, West, Ande, Smith, Richard D, Randell, Scott H, Metz, Thomas O, Sheahan, Timothy P, Waters, Katrina M, Baric, Ralph S

“…Tissue- and cell-specific expression patterns are highly variable within and across individuals, leading to altered host responses after acute virus infection…”
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