Search Results - "Grainger, R"

The Role of Retinoic Acid in Tolerance and Immunity by Hall, Jason A., Grainger, John R., Spencer, Sean P., Belkaid, Yasmine

“…Vitamin A elicits a broad array of immune responses through its metabolite, retinoic acid (RA). Recent evidence indicates that loss of RA leads to impaired…”
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Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression by Shaw, Tovah N, Houston, Stephanie A, Wemyss, Kelly, Bridgeman, Hayley M, Barbera, Thomas A, Zangerle-Murray, Tamsin, Strangward, Patrick, Ridley, Amanda J L, Wang, Ping, Tamoutounour, Samira, Allen, Judith E, Konkel, Joanne E, Grainger, John R

“…A defining feature of resident gut macrophages is their high replenishment rate from blood monocytes attributed to tonic commensal stimulation of this site. In…”
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Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity by Hewitson, James P., Grainger, John R., Maizels, Rick M.

“…Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a Th2-dominated immune response, but stimulation of…”
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COVID-19 therapeutics: Challenges and directions for the future by Robinson, Philip C, Liew, David F L, Tanner, Helen L, Grainger, John R, Dwek, Raymond A, Reisler, Ronald B, Steinman, Lawrence, Feldmann, Marc, Ho, Ling-Pei, Hussell, Tracy, Moss, Paul, Richards, Duncan, Zitzmann, Nicole

“…The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the greatest medical emergency of the last century. COVID-19 has highlighted…”
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Macrophages in gastrointestinal homeostasis and inflammation by Grainger, John R., Konkel, Joanne E., Zangerle-Murray, Tamsin, Shaw, Tovah N.

“…Monocyte-derived mononuclear phagocytes, particularly macrophages, are crucial to maintain gastrointestinal homeostasis in the steady state but are also…”
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Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes by Jakubzick, Claudia, Gautier, Emmanuel L., Gibbings, Sophie L., Sojka, Dorothy K., Schlitzer, Andreas, Johnson, Theodore E., Ivanov, Stoyan, Duan, Qiaonan, Bala, Shashi, Condon, Tracy, van Rooijen, Nico, Grainger, John R., Belkaid, Yasmine, Ma’ayan, Avi, Riches, David W.H., Yokoyama, Wayne M., Ginhoux, Florent, Henson, Peter M., Randolph, Gwendalyn J.

“…It is thought that monocytes rapidly differentiate to macrophages or dendritic cells (DCs) upon leaving blood. Here we have shown that Ly-6C+ monocytes…”
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Known and unknown unknowns: uncertainty estimation in satellite remote sensing by Povey, A C, Grainger, R G

“…This paper discusses a best-practice representation of uncertainty in satellite remote sensing data. An estimate of uncertainty is necessary to make…”
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Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5 by Laurence, Arian, Yang, Xiang-Ping, Ghoreschi, Kamran, Steward-Tharp, Scott M, Rodriguez-Canales, Jaime, Zhu, Jinfang, Grainger, John R, Hirahara, Kiyoshi, Sun, Hong-Wei, Wei, Lai, Vahedi, Golnaz, Kanno, Yuka, O'Shea, John J

“…Loss of IL-2 signaling results in autoimmunity. Laurence and colleagues show that the IL-2–STAT5 axis counteracts STAT3 activation of Il17 to dampen IL-17…”
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Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection by Grainger, John R, Wohlfert, Elizabeth A, Fuss, Ivan J, Bouladoux, Nicolas, Askenase, Michael H, Legrand, Fanny, Koo, Lily Y, Brenchley, Jason M, Fraser, Iain D C, Belkaid, Yasmine

“…Monocytes play an important part in the clearance of pathogens during infection. Yasmine Belkaid and her colleagues now report that inflammatory monocytes can…”
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Simplifying the calculation of light scattering properties for black carbon fractal aggregates by Smith, A. J. A, Grainger, R. G

“…Black carbon fractal aggregates have complicated shapes that make the calculation of their optical properties particularly computationally expensive. Here, a…”
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Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha by Hall, Jason A., Cannons, Jennifer L., Grainger, John R., Dos Santos, Liliane M., Hand, Timothy W., Naik, Shruti, Wohlfert, Elizabeth A., Chou, David B., Oldenhove, Guillaume, Robinson, Melody, Grigg, Michael E., Kastenmayer, Robin, Schwartzberg, Pamela L., Belkaid, Yasmine

“…Vitamin A and its metabolite, retinoic acid (RA) are implicated in the regulation of immune homeostasis via the peripheral induction of regulatory T cells…”
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A new scheme for sulphur dioxide retrieval from IASI measurements: application to the Eyjafjallajökull eruption of April and May 2010 by Carboni, E, Grainger, R, Walker, J, Dudhia, A, Siddans, R

“…A new optimal estimation algorithm for the retrieval of sulphur dioxide (SO2) has been developed for the Infrared Atmospheric Sounding Interferometer (IASI)…”
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Intraluminal Containment of Commensal Outgrowth in the Gut during Infection-Induced Dysbiosis by Molloy, Michael J., Grainger, John R., Bouladoux, Nicolas, Hand, Timothy W., Koo, Lily Y., Naik, Shruti, Quinones, Mariam, Dzutsev, Amiran K., Gao, Ji-Liang, Trinchieri, Giorgio, Murphy, Philip M., Belkaid, Yasmine

“…Shifts in commensal microbiota composition are emerging as a hallmark of gastrointestinal inflammation. In particular, outgrowth of γ-proteobacteria has been…”
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Thymocyte apoptosis drives the intrathymic generation of regulatory T cells by Konkel, Joanne E, Jin, Wenwen, Abbatiello, Brittany, Grainger, John R, Chen, WanJun

“…Maintenance of immune tolerance critically depends upon regulatory T cells that express the transcription factor forkhead box P3 (Foxp3). These CD4 ⁺ T cells…”
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Approaches to the detection of Clostridioides difficile in the healthcare environment by Grainger, R.J., Stevens, N.T., Humphreys, H.

“…Clostridioides difficile, a spore-forming bacillus, is a major cause of healthcare-associated infection, and can survive for prolonged periods in the inanimate…”
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Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection by Filbey, Kara J, Grainger, John R, Smith, Katherine A, Boon, Louis, Rooijen, Nico, Harcus, Yvonne, Jenkins, Stephen, Hewitson, James P, Maizels, Rick M

“…The nematode Heligmosomoides polygyrus is an excellent model for intestinal helminth parasitism. Infection in mice persists for varying lengths of time in…”
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Hematopoietic stem and progenitor cells are present in healthy gingiva tissue by Krishnan, Siddharth, Wemyss, Kelly, Prise, Ian E, McClure, Flora A, O'Boyle, Conor, Bridgeman, Hayley M, Shaw, Tovah N, Grainger, John R, Konkel, Joanne E

“…Hematopoietic stem cells reside in the bone marrow, where they generate the effector cells that drive immune responses. However, in response to inflammation,…”
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Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells by Klebanoff, Christopher A, Spencer, Sean P, Torabi-Parizi, Parizad, Grainger, John R, Roychoudhuri, Rahul, Ji, Yun, Sukumar, Madhusudhanan, Muranski, Pawel, Scott, Christopher D, Hall, Jason A, Ferreyra, Gabriela A, Leonardi, Anthony J, Borman, Zachary A, Wang, Jinshan, Palmer, Douglas C, Wilhelm, Christoph, Cai, Rongman, Sun, Junfeng, Napoli, Joseph L, Danner, Robert L, Gattinoni, Luca, Belkaid, Yasmine, Restifo, Nicholas P

“…Dendritic cells (DCs) comprise distinct populations with specialized immune-regulatory functions. However, the environmental factors that determine the…”
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Correcting the record of volcanic stratospheric aerosol impact: Nabro and Sarychev Peak by Fromm, M., Kablick III, G., Nedoluha, G., Carboni, E., Grainger, R., Campbell, J., Lewis, J.

“…Since 2010, several papers have been published that reveal a pattern of discrepancies between stratospheric aerosol data from the Optical Spectrograph and…”
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Age-Related Alterations in Macrophage Distribution and Function Are Associated With Delayed Cutaneous Wound Healing by Dube, Christabel Thembela, Ong, Yasmin Hui Binn, Wemyss, Kelly, Krishnan, Siddharth, Tan, Tiak Ju, Janela, Baptiste, Grainger, John R, Ronshaugen, Matthew, Mace, Kimberly A, Lim, Chin Yan

“…Ageing-related delays and dysregulated inflammation in wound healing are well-documented in both human and animal models. However, cellular and molecular…”
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