Search Results - "Grainger, J D"

The VKORC1 and CYP2C9 genotypes are associated with over‐anticoagulation during initiation of warfarin therapy in children by BISS, T. T., AVERY, P. J., WILLIAMS, M. D., BRANDÃO, L. R., GRAINGER, J. D., KAMALI, F.

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High titres of serum antinuclear antibodies, mostly directed against nucleolar antigens, are associated with the presence of coronary atherosclerosis by Grainger, D J, Bethell, H W L

“…Background: Inappropriate inflammation is a key mechanism in the development of atherosclerosis. Antibodies against components of the atherosclerotic lesion,…”
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Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice by Grainger, David J, Kemp, Paul R, Liu, Alexander C, Lawn, Richard M, Metcalfe, James C

“…A HIGH concentration of serum lipoprotein(a) is a risk factor for atherosclerosis. Lipoprotein(a) consists of low-density lipoprotein with the additional…”
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Transforming Growth Factor β and Atherosclerosis: So Far, So Good for the Protective Cytokine Hypothesis by Grainger, David J

“…ABSTRACT—The role of the anti-inflammatory cytokine transforming growth factor β (TGF-β) in atherosclerosis has been the subject of considerable debate for a…”
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Proliferation of Human Smooth Muscle Cells Promoted by Lipoprotein(a) by Grainger, David J., Kirschenlohr, Heide L., Metcalfe, James C., Weissberg, Peter L., Wade, David P., Lawn, Richard M.

“…Elevated blood concentrations of lipoprotein(a) [Lp(a)] and its constituent, apolipoprotein(a) [apo(a)], constitute a major risk factor for atherosclerosis,…”
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International cross-cultural validation study of the Canadian Haemophilia Outcomes: Kids' Life Assessment Tool by McCusker, P. J., Fischer, K., Holzhauer, S., Meunier, S., Altisent, C., Grainger, J. D., Blanchette, V. S., Burke, T. A., Wakefield, C., Young, N. L.

“…Summary Health‐related quality of life (HRQoL) assessment is recognized as an important outcome in the evaluation of different therapeutic regimens for persons…”
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A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia by Vormoor, B., Veal, G. J., Griffin, M. J., Boddy, A. V., Irving, J., Minto, L., Case, M., Banerji, U., Swales, K. E., Tall, J. R., Moore, A. S., Toguchi, M., Acton, G., Dyer, K., Schwab, C., Harrison, C. J., Grainger, J. D., Lancaster, D., Kearns, P., Hargrave, D., Vormoor, J.

“…Aurora kinases regulate mitosis and are commonly overexpressed in leukemia. This phase I/IIa study of AT9283, a multikinase inhibitor, was designed to identify…”
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Tamoxifen: Teaching an old drug new tricks? by Grainger, David J, Metcalfe, James C

“…Tamoxifen is the most widely studied member of a class of molecules called the triphenylethylenes (TPEs). These molecules were developed by successive chemical…”
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Tamoxifen decreases cholesterol sevenfold and abolishes lipid lesion development in apolipoprotein E knockout mice by RECKLESS, J, METCALFE, J. C, GRAINGER, D. J

“…Apolipoprotein E (apo E) knockout mice develop severe vascular lipid lesions resembling human atherosclerotic plaques, irrespective of the fat content of their…”
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Increased PAI activity and PAI-1 antigen occurring with an oral fat load: associations with PAI-1 genotype and plasma active TGF- β levels by Byrne, C.D, Wareham, N.J, Martensz, N.D, Humphries, S.E, Metcalfe, J.C, Grainger, D.J

“…Whether the post-prandial lipemic response is linked to potentially pro-atherogenic and/or prothrombotic changes in plasminogen activator inhibitor (PAI) and…”
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Monocyte chemoattractant protein-1 but not tumor necrosis factor-α is correlated with monocyte infiltration in mouse lipid lesions by RECKLESS, J, RUBIN, E. M, VERSTUYFT, J. B, METCALFE, J. C, GRAINGER, D. J

“…Apolipoprotein (apo)(a) transgenic mice and C57BL/6 mice fed a high fat diet develop similar-sized lipid lesions, but lesions in apo(a) mice are devoid of…”
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Neonatal alloimmune thrombocytopenia with significant HLA antibodies by Grainger, J D, Morrell, G, Yates, J, Deleacy, D

“…A case of neonatal alloimmune thrombocytopenia (NAIT) secondary to human platelet antigen (HPA)-1a antibodies is reported. Additional multispecific HLA…”
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Formation of a functional morphogen gradient by a passive process in tissue from the early Xenopus embryo by McDowell, N, Gurdon, J B, Grainger, D J

“…In early development much of the cellular diversity and pattern formation of the embryo is believed to be set up by morphogens. However, for many morphogens,…”
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Quality of life in immune thrombocytopenia following treatment by Grainger, John D, Young, Nancy L, Blanchette, Victor S, Klaassen, Robert J

“…Objective To determine the impact of therapy on the reported health-related quality of life (HRQoL) in children with primary immune thrombocytopenia (ITP)…”
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The role of serum TGF-beta isoforms as potential markers of osteoporosis by Grainger, D J, Percival, J, Chiano, M, Spector, T D

“…Osteoporosis is a major public health problem characterized by low bone mineral density (BMD) that presently has no biochemical test useful for its diagnosis…”
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The pan‐chemokine inhibitor NR58‐3.14.3 abolishes tumour necrosis factor‐α accumulation and leucocyte recruitment induced by lipopolysaccharide in vivo by Reckless, Jill, Tatalick, Lauren M., Grainger, David J.

“…Summary Chemokines participate in the regulation of leucocyte recruitment in a wide variety of inflammatory processes, including host defence and diseases such…”
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Genetic control of the circulating concentration of transforming growth factor type beta 1 by Grainger, D J, Heathcote, K, Chiano, M, Snieder, H, Kemp, PR, Metcalfe, J C, Carter, N D, Spector, T D

“…The concentration of transforming growth factor beta (TGF- beta ) in plasma has been correlated with the development of several diseases, including…”
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Identification of oligopeptide sequences which inhibit migration induced by a wide range of chemokines by Reckless, J, Grainger, D J

“…We have identified an amino acid sequence, termed peptide 3, corresponding to amino acids 51-62 of the mature human monocyte chemoattractant protein-1 (MCP-1),…”
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Transforming growth factor β decreases the rate of proliferation of rat vascular smooth muscle cells by extending the G2 phase of the cell cycle and delays the rise in cyclic AMP before entry into M phase by GRAINGER, D. J, KEMP, P. R, WITCHELL, C. M, WEISSBERG, P. L, METCALFE, J. C

“…Transforming growth factor beta 1 (TGF-beta 1) decreased the rate of proliferation of rat aortic vascular smooth muscle cells (VSMCs) stimulated with serum…”
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Adult human aortic smooth muscle cells in culture produce active TGF-beta by Kirschenlohr, H L, Metcalfe, J C, Weissberg, P L, Grainger, D J

“…Vascular smooth muscle cells (VSMC) from adult human aortas proliferated in culture in response to fetal calf serum (FCS) with a population doubling time of…”
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