Search Results - "Grahovac, Jelena"

Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance by Erin, Nuray, Grahovac, Jelena, Brozovic, Anamaria, Efferth, Thomas

“…It is well established that multifactorial drug resistance hinders successful cancer treatment. Tumor cell interactions with the tumor microenvironment (TME)…”
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Analysis of the nischarin expression across human tumor types reveals its context-dependent role and a potential as a target for drug repurposing in oncology by Ostojić, Marija, Đurić, Ana, Živić, Kristina, Grahovac, Jelena

“…Nischarin was reported to be a tumor suppressor that plays a critical role in breast cancer initiation and progression, and a positive prognostic marker in…”
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Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy by Incio, Joao, Liu, Hao, Suboj, Priya, Chin, Shan M, Chen, Ivy X, Pinter, Matthias, Ng, Mei R, Nia, Hadi T, Grahovac, Jelena, Kao, Shannon, Babykutty, Suboj, Huang, Yuhui, Jung, Keehoon, Rahbari, Nuh N, Han, Xiaoxing, Chauhan, Vikash P, Martin, John D, Kahn, Julia, Huang, Peigen, Desphande, Vikram, Michaelson, James, Michelakos, Theodoros P, Ferrone, Cristina R, Soares, Raquel, Boucher, Yves, Fukumura, Dai, Jain, Rakesh K

“…It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes…”
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The crosstalk between breast carcinoma-associated fibroblasts and cancer cells promotes RhoA-dependent invasion via IGF-1 and PAI-1 by Daubriac, Julien, Han, Shiwei, Grahovac, Jelena, Smith, Eve, Hosein, Abdel, Buchanan, Marguerite, Basik, Mark, Boucher, Yves

“…Carcinoma-associated fibroblasts (CAFs) can remodel the extracellular matrix to promote cancer cell invasion, but the paracrine signaling between CAFs and…”
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Telmisartan induces melanoma cell apoptosis and synergizes with vemurafenib in vitro by altering cell bioenergetics by Grahovac, Jelena, Srdić-Rajić, Tatjana, Francisco Santibañez, Juan, Pavlović, Marijana, Čavić, Milena, Radulović, Siniša

“…Despite recent advancements in targeted therapy and immunotherapies, prognosis for metastatic melanoma patients remains extremely poor. Development of…”
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Telmisartan induces melanoma cell apoptosis and synergizes with vemurafenib in vitro by altering cell bioenergetics by Jelena, Grahovac, Tatjana, Srdić-Rajić, Juan, Francisco Santibañez, Marijana, Pavlović, Milena, Čavić, Siniša, Radulović

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Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion by Grahovac, Jelena, Wells, Alan

“…Cancer invasion is a complex process requiring, among other events, extensive remodeling of the extracellular matrix including deposition of pro-migratory and…”
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Targeting tumor cell motility as a strategy against invasion and metastasis by Wells, Alan, Grahovac, Jelena, Wheeler, Sarah, Ma, Bo, Lauffenburger, Douglas

“…Advances in diagnosis and treatment have rendered most solid tumors largely curable if they are diagnosed and treated before dissemination. However, once they…”
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A Fluorescence-Based Assay for Measuring Glucose Uptake in Living Melanoma Cells by Grahovac, Jelena, Pavlović, Marijana, Ostojić, Marija

“…Melanoma cells have high glycolytic capacity. Glucose uptake is a key rate-limiting step in glucose utilization. Here we describe a simple protocol for…”
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Repurposing old drugs to fight multidrug resistant cancers by Dinić, Jelena, Efferth, Thomas, García-Sosa, Alfonso T., Grahovac, Jelena, Padrón, José M., Pajeva, Ilza, Rizzolio, Flavio, Saponara, Simona, Spengler, Gabriella, Tsakovska, Ivanka

“…Overcoming multidrug resistance represents a major challenge for cancer treatment. In the search for new chemotherapeutics to treat malignant diseases, drug…”
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Abstract PO-040: Nischarin is expressed in pancreatic ductal adenocarcinoma and is a potential target for drug repurposing by Grahovac, Jelena, Pavlovic, Marijana, Ostojic, Marija, Zivic, Kristina, Galun, Daniel, Srdic-Rajic, Tatjana

“…Abstract The objective of this study was to examine the expression of Nischarin (NISCH) in pancreatic ductal adenocarcinoma (PDAC), and its potential as a…”
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Melanoma Cell Invasiveness Is Promoted at Least in Part by the Epidermal Growth Factor–Like Repeats of Tenascin-C by Grahovac, Jelena, Becker, Dorothea, Wells, Alan

“…Tenascin-C (TNC), overexpressed in invasive growths, has been implicated in progression of melanoma, but the source and function of this molecule are not well…”
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Abstract LT002: The therapeutically inflamed tumor microenvironment drives melanoma progression by Bradshaw, Andrew, Kuo, Erica, Grahovac, Jelena, Sander, Cindy, Edington, Howard, Kirkwood, John M., Wells, Alan

“…Abstract How microenvironmental inflammation impacts melanoma progression remains controversial. Inflammation appears beneficial during interferon stimulated…”
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Abstract 485: Epidermal growth factor-like repeats of Tenascin C promote melanoma cell invasion, possibly by enabling mesenchymal to ameboid migration transition by Grahovac, Jelena, Wells, Alan

“…Abstract In malignant melanoma, the most dangerous skin cancer, Tenascin-C (TNC) is overexpressed, especially at the invasive fronts of invasive melanomas. We…”
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Analysis of the nischarin expression across human tumor types reveals its context-dependent role and a potential as a target for drug repurposing in oncology by Marija Ostojić, Ana Đurić, Kristina Živić, Jelena Grahovac

“…Nischarin was reported to be a tumor suppressor that plays a critical role in breast cancer initiation and progression, and a positive prognostic marker in…”
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Abstract 3169: The therapeutically inflamed tumor microenvironment drives melanoma progression by Bradshaw, Andrew M., Kuo, Erica, Grahovac, Jelena, Sylakowski, Kyle, Sander, Cindy, Edington, Howard, Kirkwood, John M., Wells, Alan

“…Abstract Even the most therapy responsive melanomas eventually evade immune checkpoint inhibition. Interestingly, initial responses seem to benefit from…”
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Abstract B41: The angiotensin receptor blocker telmisartan inhibits the growth of pancreatic ductal adenocarcinoma and improves survival by Grahovac, Jelena, Han, Shiwei, Liu, Hao, Jain, Rakesh, Boucher, Yves

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer with a 5-year survival rate of less than 5%. PDAC is highly…”
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Abstract 421: Epidermal growth factor-like repeats of tenascin C alter melanoma cell migration both directly and through alteration of the ECM by Grahovac, Jelena, Wells, Alan

“…Abstract In melanoma, the most aggressive type of skin cancer, invasion through the extracellular matrix (ECM) is a harbinger of dissemination and mortality…”
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Nischarin expression may have differing roles in male and female melanoma patients by Ostojić, Marija, Jevrić, Marko, Mitrović-Ajtić, Olivera, Živić, Kristina, Tanić, Miljana, Čavić, Milena, Srdić-Rajić, Tatjana, Grahovac, Jelena

“…Due to the development of resistance to previously effective therapies, there is a constant need for novel treatment modalities for metastatic melanoma…”
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Prognostic Value of Combined Hematological/Biochemical Indexes and Tumor Clinicopathologic Features in Colorectal Cancer Patients-A Pilot Single Center Study by Cuk, Vladica, Karamarkovic, Aleksandar, Juloski, Jovan, Arbutina, Dragana, Radulovic, Radosav, Milic, Ljiljana, Kovacevic, Bojan, De Luka, Silvio, Grahovac, Jelena

“…Colorectal cancer (CRC) is a significant public health problem. There is increasing evidence that the host's immune response and nutritional status play a role…”
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