Search Results - "Grahn, M. F."

Butyrate oxidation is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis by Chapman, M A, Grahn, M F, Boyle, M A, Hutton, M, Rogers, J, Williams, N S

“…The short chain fatty acids, acetate, propionate, and butyrate are produced by colonic bacterial fermentation of non-starch polysaccharides. Butyrate is the…”
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Fibrin glue in the management of anal fistulae by Hammond, T. M., Grahn, M. F., Lunniss, P. J.

“…Objective  Fibrin glue has been used as a sphincter sparing approach for the treatment of anal fistulae for two decades. However, there is uncertainty about…”
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Butyrate metabolism in the terminal ileal mucosa of patients with ulcerative colitis by Chapman, M A, Grahn, M F, Hutton, M, Williams, N S

“…The rate of oxidation of butyrate, glutamine and glucose was investigated in terminal ileal mucosal biopsy samples from nine patients with ulcerative colitis…”
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Increased Activity and Sensitivity of Mitochondrial Respiratory Enzymes to Tumor Necrosis Factor α-Mediated Inhibition Is Associated With Increased Cytotoxicity in Drug-Resistant Leukemic Cell Lines by Jia, Li, Kelsey, Stephen M., Grahn, Michael F., Jiang, Xu-Rong, Newland, Adrian C.

“…The drug-resistant leukemic cell lines, CEM/VLB100 and K/DAU500, are more sensitive to tumor necrosis factor α (TNFα)-mediated cytotoxicity compared with their…”
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Metabolic adaptation of terminal ileal mucosa after construction of an ileoanal pouch by Chapman, M. A. S., Hutton, M., Grahn, M. F., Williams, N. S.

“…Background The major nutrients for the large bowel and small bowel mucosa are, respectively, butyrate and glutamine. The degree of mucosal adaptation that may…”
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Mitochondrial electron transport chain activity, but not ATP synthesis, is required for drug‐induced apoptosis in human leukaemic cells: a possible novel mechanism of regulating drug resistance by Jia, Li, Allen, Paul D., Macey, Marion G., Grahn, Michael F., Newland, Adrian C., Kelsey, Stephen M.

“…There is increasing evidence for an association between mitochondrial function and susceptibility to apoptosis. It has been shown that the…”
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A comparison of novel light sources for photodynamic therapy by De Jode, M L, McGilligan, J A, Dilkes, M G, Cameron, I, Hart, P B, Grahn, M F

“…A diode laser, light-emitting diode (LED) array bandwidth 25 nm, full width half maximum (FWHM) and filtered arc lamp (bandwidth 40 nm, FWHM), all with peak…”
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New technique to measure mucosal metabolism and its use to map substrate utilization in the healthy human large bowel by Chapman, M A, Grahn, M F, Giamundo, P, O'Connell, P R, Onwu, D, Hutton, M, Maudsley, J, Norton, B, Rogers, J, Williams, N S

“…A new method of assessing substrate utilization in gastrointestinal mucosal specimens is described. Small human endoscopic biopsy specimens with wet weights…”
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Characterization of a murine model for the rapid assessment of acute photodynamic response in tumour and muscle by Ansell, J K, De Jode, M L, Grahn, M F

“…A murine implanted colorectal tumour model is described in which a measurement of tumour depth of necrosis is combined with a simultaneous measurement of…”
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Simultaneous dynamic electromyographic proctography and cystometrography by Thorpe, A C, Williams, N S, Badenoch, D F, Blandy, J P, Grahn, M F

“…The rectum and bladder share a common origin and work in harmony; disturbance in one may lead to a similar problem in the other. The two have, however, not…”
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mTHPC Polymer Conjugates: The In Vivo Photodynamic Activity of Four Candidate Compounds by Grahn, M F, Giger, A, McGuinness, A, de Jode, M L, Stewart, J C, Ris, H B, Altermatt, H J, Williams, N S

“…The in vivo photodynamic activities of four poly(ethylene glycol) (PEG) conjugates of the photosensitiser 5,10,15,20-tetrakis-(m-hydroxyphenyl)chlorin (mTHPC,…”
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Tissue photosensitizer detection by low-power remittance fluorimetry by Grahn, M F, De Jode, M L, Dilkes, M G, Ansell, J K, Onwu, D, Maudsley, J, Williams, N S

“…A simple adaptation of a commercial spectrofluorimeter which allows the semiquantitative determination of photodynamic therapy photosensitizer fluorescence in…”
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Ileal and colonic epithelial metabolism in quiescent ulcerative colitis by Chapman, M A, Grahn, M F

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In vitro modulation of haematoporphyrin derivative photodynamic therapy on colorectal carcinoma multicellular spheroids by verapamil by Purkiss, S F, Grahn, M F, Turkish, M, Macey, M G, Williams, N S

“…Photodynamic therapy has possible applications in the treatment of colorectal carcinoma. The photosensitizer haematoporphyrin derivative (HpD) is selectively…”
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Haematoporphyrin derivative—Photodynamic therapy of colorectal carcinoma, sensitized using verapamil and adriamycin by Purkiss, S.F., Grahn, M.F., Williams, N.S.

“…The p-glycoprotein export mechanism may have an effect on the cytotoxicity of chemotherapy or photodynamic therapy (PDT) by reducing cytotoxic drug or…”
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Adjuvant intraoperative photodynamic therapy for colorectal carcinoma: a clinical study by Allardice, J T, Abulafi, A M, Grahn, M F, Williams, N S

“…The local recurrence rate of colorectal carcinoma after surgery is unacceptable in most series, and adjuvant therapies have made only a small impact on this…”
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Activation by reduction of the resting form of cytochrome c oxidase: tests of different models and evidence for the involvement of CuB by Wrigglesworth, J M, Elsden, J, Chapman, A, Van der Water, N, Grahn, M F

“…(1) The reaction of the resting form of oxidised cytochrome c oxidase from ox heart with dithionite has been studied in the presence and absence of cyanide. In…”
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Multiple fibre interstitial photodynamic therapy of patients with colorectal liver metastases by PURKISS, S. F, GRAHN, M. F, ABULAFI, A. M, DEAN, R, ALLARDICE, J. T, WILLIAMS, N. S

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Mucosal metabolic activity in endoscopic intestinal biopsy specimens by Giamundo, P, Grahn, M F, O'Connell, P R, Williams, N S

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Biodistribution and Bioactivity of Tetra-pegylated Meta-tetra(hydroxyphenyl)chlorin Compared to Native Meta-tetra(hydroxyphenyl)chlorin in a Rat Liver Tumor Model by Rovers, Jeroen P., Saarnak, Anne E., Jode, Martin de, Sterenborg, Hendricus J. C M., Terpstra, Onno T., Grahn, Michael F.

“…It has been proposed that the construction of a photosensitizer–polymer conjugate would lead to an increased selective retention of the drug in tumor tissue…”
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