Search Results - "Graham, Stewart F"

Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease by Graham, Stewart F, Chevallier, Olivier P, Elliott, Christopher T, Hölscher, Christian, Johnston, Janet, McGuinness, Bernadette, Kehoe, Patrick G, Passmore, Anthony Peter, Green, Brian D

“…This study combined high resolution mass spectrometry (HRMS), advanced chemometrics and pathway enrichment analysis to analyse the blood metabolome of patients…”
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Enhanced fatty acid oxidation provides glioblastoma cells metabolic plasticity to accommodate to its dynamic nutrient microenvironment by Kant, Shiva, Kesarwani, Pravin, Prabhu, Antony, Graham, Stewart F., Buelow, Katie L., Nakano, Ichiro, Chinnaiyan, Prakash

“…Despite advances in molecularly characterizing glioblastoma (GBM), metabolic alterations driving its aggressive phenotype are only beginning to be recognized…”
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Artificial intelligence and the analysis of multi-platform metabolomics data for the detection of intrauterine growth restriction by Bahado-Singh, Ray Oliver, Yilmaz, Ali, Bisgin, Halil, Turkoglu, Onur, Kumar, Praveen, Sherman, Eric, Mrazik, Andrew, Odibo, Anthony, Graham, Stewart F

“…To interrogate the pathogenesis of intrauterine growth restriction (IUGR) and apply Artificial Intelligence (AI) techniques to multi-platform i.e. nuclear…”
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Alzheimer's Precision Neurology: Epigenetics of Cytochrome P450 Genes in Circulating Cell-Free DNA for Disease Prediction and Mechanism by Bahado-Singh, Ray O, Vishweswaraiah, Sangeetha, Turkoglu, Onur, Graham, Stewart F, Radhakrishna, Uppala

“…Precision neurology combines high-throughput technologies and statistical modeling to identify novel disease pathways and predictive biomarkers in Alzheimer's…”
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Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome by Pan, Xiaobei, Nasaruddin, Muhammad Bin, Elliott, Christopher T, McGuinness, Bernadette, Passmore, Anthony P, Kehoe, Patrick G, Hölscher, Christian, McClean, Paula L, Graham, Stewart F, Green, Brian D

“…Abstract The pathogenesis of Alzheimer's disease (AD) is complex involving multiple contributing factors. The extent to which AD pathology affects the…”
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Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma by Kesarwani, Pravin, Prabhu, Antony, Kant, Shiva, Kumar, Praveen, Graham, Stewart F, Buelow, Katie L, Wilson, George D, Miller, C Ryan, Chinnaiyan, Prakash

“…Immune checkpoint inhibitors designed to revert tumor-induced immunosuppression have emerged as potent anticancer therapies. Tryptophan metabolism represents…”
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Biochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles by Graham, Stewart F, Rey, Nolwen L, Yilmaz, Ali, Kumar, Praveen, Madaj, Zachary, Maddens, Michael, Bahado-Singh, Ray O, Becker, Katelyn, Schulz, Emily, Meyerdirk, Lindsay K, Steiner, Jennifer A, Ma, Jiyan, Brundin, Patrik

“…Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well…”
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Untargeted metabolomics reveals distinct metabolic reprogramming in endothelial cells co-cultured with CSC and non-CSC prostate cancer cell subpopulations by Jayaraman, Anusha, Kumar, Praveen, Marin, Silvia, de Atauri, Pedro, Mateo, Francesca, M Thomson, Timothy, J Centelles, Josep, F Graham, Stewart, Cascante, Marta

“…Tumour angiogenesis is an important hallmark of cancer and the study of its metabolic adaptations, downstream to any cellular change, can reveal attractive…”
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The longitudinal biochemical profiling of TBI in a drop weight model of TBI by Yilmaz, Ali, Liraz-Zaltsman, Sigal, Shohami, Esther, Gordevičius, Juozas, Kerševičiūtė, Ieva, Sherman, Eric, Bahado-Singh, Ray O., Graham, Stewart F.

“…Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide, particularly among individuals under the age of 45. It is a complex, and…”
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Untargeted Metabolomic Biomarker Discovery for the Detection of Ectopic Pregnancy by Turkoglu, Onur, Citil, Ayse, Katar, Ceren, Mert, Ismail, Quinn, Robert A, Bahado-Singh, Ray O, Graham, Stewart F

“…Ectopic pregnancy (EP) is the leading cause of maternal morbidity and mortality in the first trimester. Using an untargeted metabolomic approach, we sought to…”
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Investigation of the Human Brain Metabolome to Identify Potential Markers for Early Diagnosis and Therapeutic Targets of Alzheimer’s Disease by Graham, Stewart F, Chevallier, Olivier P, Roberts, Dominic, Hölscher, Christian, Elliott, Christopher T, Green, Brian D

“…A study combining high resolution mass spectrometry (liquid chromatography-quadrupole time-of-flight-mass spectrometry, UPLC-QTof-MS) and chemometrics for the…”
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Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson's Disease by Li, Peipei, Killinger, Bryan A, Ensink, Elizabeth, Beddows, Ian, Yilmaz, Ali, Lubben, Noah, Lamp, Jared, Schilthuis, Meghan, Vega, Irving E, Woltjer, Randy, Pospisilik, J Andrew, Brundin, Patrik, Brundin, Lena, Graham, Stewart F, Labrie, Viviane

“…The gut microbiome can impact brain health and is altered in Parkinson's disease (PD). The vermiform appendix is a lymphoid tissue in the cecum implicated in…”
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Lipid Profiling of Alzheimer's Disease Brain Highlights Enrichment in Glycerol(phospho)lipid, and Sphingolipid Metabolism by Akyol, Sumeyya, Ugur, Zafer, Yilmaz, Ali, Ustun, Ilyas, Gorti, Santosh Kapil Kumar, Oh, Kyungjoon, McGuinness, Bernadette, Passmore, Peter, Kehoe, Patrick G, Maddens, Michael E, Green, Brian D, Graham, Stewart F

“…Alzheimer's disease (AD) is reported to be closely linked with abnormal lipid metabolism. To gain a more comprehensive understanding of what causes AD and its…”
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Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease by Bahado-Singh, Ray O, Vishweswaraiah, Sangeetha, Aydas, Buket, Yilmaz, Ali, Metpally, Raghu P, Carey, David J, Crist, Richard C, Berrettini, Wade H, Wilson, George D, Imam, Khalid, Maddens, Michael, Bisgin, Halil, Graham, Stewart F, Radhakrishna, Uppala

“…We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA…”
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Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer's Disease by Pan, Xiaobei, Elliott, Christopher T, McGuinness, Bernadette, Passmore, Peter, Kehoe, Patrick G, Hölscher, Christian, McClean, Paula L, Graham, Stewart F, Green, Brian D

“…Certain endogenous bile acids have been proposed as potential therapies for ameliorating Alzheimer's disease (AD) but their role, if any, in the…”
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Metabolomics: An Emerging "Omics" Platform for Systems Biology and Its Implications for Huntington Disease Research by Akyol, Sumeyya, Ashrafi, Nadia, Yilmaz, Ali, Turkoglu, Onur, Graham, Stewart F

“…Huntington's disease (HD) is a progressive, fatal neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms. The precise mechanisms…”
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Methylated Cytochrome P450 and the Solute Carrier Family of Genes Correlate With Perturbations in Bile Acid Metabolism in Parkinson's Disease by Vishweswaraiah, Sangeetha, Akyol, Sumeyya, Yilmaz, Ali, Ugur, Zafer, Gordevičius, Juozas, Oh, Kyung Joon, Brundin, Patrik, Radhakrishna, Uppala, Labrie, Viviane, Graham, Stewart F

“…Parkinson's disease (PD) is second most prevalent neurodegenerative disorder following Alzheimer's disease. Parkinson's disease is hypothesized to be caused by…”
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Targeted Metabolic Profiling of Urine Highlights a Potential Biomarker Panel for the Diagnosis of Alzheimer’s Disease and Mild Cognitive Impairment: A Pilot Study by Yilmaz, Ali, Ugur, Zafer, Bisgin, Halil, Akyol, Sumeyya, Bahado-Singh, Ray, Wilson, George, Imam, Khaled, Maddens, Michael E., Graham, Stewart F.

“…The lack of sensitive and specific biomarkers for the early detection of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is a major hurdle to…”
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Targeted metabolomics highlights perturbed metabolism in the brain of autism spectrum disorder sufferers by Graham, Stewart F., Turkoglu, Onur, Yilmaz, Ali, Ustun, Ilyas, Ugur, Zafer, Bjorndhal, Trent, Han, BeomSoo, Mandal, Rupa, Wishart, David, Bahado-Singh, Ray O.

“…Introduction Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by deficiencies in social interactions and communication,…”
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Association of Metabolomic Biomarkers with Sleeve Gastrectomy Weight Loss Outcomes by Miller, Wendy M, Ziegler, Kathryn M, Yilmaz, Ali, Saiyed, Nazia, Ustun, Ilyas, Akyol, Sumeyya, Idler, Jay, Sims, Matthew D, Maddens, Michael E, Graham, Stewart F

“…This prospective observational study aimed to evaluate the association of metabolomic alterations with weight loss outcomes following sleeve gastrectomy (SG)…”
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