Search Results - "Graham, Russell"

Bisphosphonates: The first 40 years by Russell, R. Graham G

“…Abstract The first full publications on the biological effects of the diphosphonates, later renamed bisphosphonates, appeared in 1969, so it is timely after 40…”
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Denosumab and bisphosphonates: Different mechanisms of action and effects by Baron, Roland, Ferrari, Serge, Russell, R. Graham G

“…Abstract To treat systemic bone loss as in osteoporosis and/or focal osteolysis as in rheumatoid arthritis or periodontal disease, most approaches target the…”
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Pharmacology of bisphosphonates by Cremers, Serge, Drake, Matthew T., Ebetino, F. Hal, Bilezikian, John P., Russell, R. Graham G.

“…The biological effects of the bisphosphonates (BPs) as inhibitors of calcification and bone resorption were first described in the late 1960s. In the 50 years…”
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Bisphosphonates: Mode of Action and Pharmacology by Russell, R. Graham G

“…The profound effects of the bisphosphonates on calcium metabolism were discovered over 30 years ago, and they are now well established as the major drugs used…”
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Pyrophosphate: a key inhibitor of mineralisation by Orriss, Isabel R, Arnett, Timothy R, Russell, R Graham G

“…Highlights • Pyrophosphate prevents unwanted calcification making it the body's natural ‘water-softener’. • The breakdown of ATP released from cells represents…”
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The Molecular Mechanism of Nitrogen-Containing Bisphosphonates as Antiosteoporosis Drugs by Kavanagh, Kathryn L., Guo, Kunde, Dunford, James E., Wu, Xiaoqiu, Knapp, Stefan, Ebetino, Frank H., Rogers, Michael J., Russell, Graham G., Oppermann, Udo

“…Osteoporosis and low bone mass are currently estimated to be a major public health risk affecting > 50% of the female population over the age of 50. Because of…”
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Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms by Sedghizadeh, Parish P, Sun, Shuting, Junka, Adam F, Richard, Eric, Sadrerafi, Keivan, Mahabady, Susan, Bakhshalian, Neema, Tjokro, Natalia, Bartoszewicz, Marzenna, Oleksy, Monika, Szymczyk, Patrycja, Lundy, Mark W, Neighbors, Jeffrey D, Russell, R. Graham G, McKenna, Charles E, Ebetino, Frank H

“…Osteomyelitis is a major problem worldwide and is devastating due to the potential for limb-threatening sequelae and mortality. Osteomyelitis pathogens are…”
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Timing and causes of mid-Holocene mammoth extinction on St. Paul Island, Alaska by Graham, Russell W., Belmecheri, Soumaya, Choy, Kyungcheol, Culleton, Brendan J., Davies, Lauren J., Froese, Duane, Heintzman, Peter D., Hritz, Carrie, Kapp, Joshua D., Newsom, Lee A., Rawcliffe, Ruth, Saulnier-Talbot, Émilie, Shapiro, Beth, Wang, Yue, Williams, John W., Wooller, Matthew J.

“…Relict woolly mammoth (Mammuthus primigenius) populations survived on several small Beringian islands for thousands of years after mainland populations went…”
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Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline by Ralston, Stuart H, Corral‐Gudino, Luis, Cooper, Cyrus, Francis, Roger M, Fraser, William D, Gennari, Luigi, Guañabens, Núria, Javaid, M Kassim, Layfield, Robert, O'Neill, Terence W, Russell, R Graham G, Stone, Michael D, Simpson, Keith, Wilkinson, Diana, Wills, Ruth, Zillikens, M Carola, Tuck, Stephen P

“…ABSTRACT An evidence‐based clinical guideline for the diagnosis and management of Paget's disease of bone (PDB) was developed using GRADE methodology, by a…”
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The relationship between the chemistry and biological activity of the bisphosphonates by Ebetino, Frank H, Hogan, Anne-Marie L, Sun, Shuting, Tsoumpra, Maria K, Duan, Xuchen, Triffitt, James T, Kwaasi, Aaron A, Dunford, James E, Barnett, Bobby L, Oppermann, Udo, Lundy, Mark W, Boyde, Alan, Kashemirov, Boris A, McKenna, Charles E, Russell, R. Graham G

“…Abstract The ability of bisphosphonates ((HO)2 P(O)CR1 R2 P(O)(OH)2 ) to inhibit bone resorption has been known since the 1960s, but it is only recently that a…”
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Pharmacological diversity among drugs that inhibit bone resorption by Russell, R Graham G

“…Highlights • ‘Anti-resorptive’ drugs inhibit osteoclast differentiation or function by diverse mechanisms. • Bisphosphonates are still the major drugs used for…”
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Mechanistic modeling of environmental drivers of woolly mammoth carrying capacity declines on St. Paul Island by Wang, Yue, Porter, Warren, Mathewson, Paul D., Miller, Paul A., Graham, Russell W., Williams, John W.

“…On St. Paul Island, a remnant of the Bering Land Bridge, woolly mammoths persisted until 5,600 yr BP with no known predators or competitors, providing a…”
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Differences in intracellular localisation of ANKH mutants that relate to mechanisms of calcium pyrophosphate deposition disease and craniometaphyseal dysplasia by Vijen, Sunny, Hawes, Chris, Runions, John, Russell, R. Graham G., Wordsworth, B. Paul, Carr, Andrew J., Pink, Ryan C., Zhang, Yun

“…ANKH mutations are associated with calcium pyrophosphate deposition disease and craniometaphyseal dysplasia. This study investigated the effects of these ANKH…”
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Caught in a bottleneck: Habitat loss for woolly mammoths in central North America and the ice‐free corridor during the last deglaciation by Wang, Yue, Widga, Chris, Graham, Russell W., McGuire, Jenny L., Porter, Warren, Wårlind, David, Williams, John W., Lyons, Kathleen

“…Aim Identifying how climate change, habitat loss, and corridors interact to influence species survival or extinction is critical to understanding macro‐scale…”
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Bisphosphonates in dentistry: Historical perspectives, adverse effects, and novel applications by Sedghizadeh, Parish P., Sun, Shuting, Jones, Allan C., Sodagar, Esmat, Cherian, Philip, Chen, Casey, Junka, Adam F., Neighbors, Jeffrey D., McKenna, Charles E., Russell, R. Graham G., Ebetino, Frank H.

“…Studies of the potential role of bisphosphonates in dentistry date back to physical chemical research in the 1960s, and the genesis of the discovery of…”
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Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo by Roelofs, Anke J, Stewart, Charlotte A, Sun, Shuting, Błażewska, Katarzyna M, Kashemirov, Boris A, McKenna, Charles E, Russell, R Graham G, Rogers, Michael J, Lundy, Mark W, Ebetino, Frank H, Coxon, Fraser P

“…Bisphosphonates are widely used antiresorptive drugs that bind to calcium. It has become evident that these drugs have differing affinities for bone mineral;…”
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In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers by Samakkarnthai, Parinya, Saul, Dominik, Zhang, Lei, Aversa, Zaira, Doolittle, Madison L, Sfeir, Jad G, Kaur, Japneet, Atkinson, Elizabeth J, Edwards, James R, Russell, Graham G, Pignolo, Robert J, Kirkland, James L, Tchkonia, Tamar, Niedernhofer, Laura J, Monroe, David G, Lebrasseur, Nathan K, Farr, Joshua N, Robbins, Paul D, Khosla, Sundeep

“…In addition to reducing fracture risk, zoledronic acid has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in…”
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Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone‐Relevant Cell Types by Roca‐Ayats, Neus, Ng, Pei Ying, Garcia‐Giralt, Natàlia, Falcó‐Mascaró, Maite, Cozar, Mónica, Abril, Josep Francesc, Quesada Gómez, José Manuel, Prieto‐Alhambra, Daniel, Nogués, Xavier, Dunford, James E, Russell, R Graham, Baron, Roland, Grinberg, Daniel, Balcells, Susana, Díez‐Pérez, Adolfo

“…ABSTRACT Atypical femoral fractures (AFFs) are a rare but potentially devastating event, often but not always linked to bisphosphonate (BP) therapy. The…”
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Reduced colon cancer incidence and mortality in postmenopausal women treated with an oral bisphosphonate—Danish National Register Based Cohort Study by Pazianas, M., Abrahamsen, B., Eiken, P. A., Eastell, R., Russell, R. Graham G.

“…Summary In this Danish national register-based cohort study, we examined the effects of alendronate on the development of colon cancers and survival. The…”
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Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine by Sun, Shuting, Błażewska, Katarzyna M, Kadina, Anastasia P, Kashemirov, Boris A, Duan, Xuchen, Triffitt, James T, Dunford, James E, Russell, R. Graham G, Ebetino, Frank H, Roelofs, Anke J, Coxon, Fraser P, Lundy, Mark W, McKenna, Charles E

“…A bone imaging toolkit of 21 fluorescent probes with variable spectroscopic properties, bone mineral binding affinities, and antiprenylation activities has…”
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