Search Results - "Graham, Leah C."

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models by Jay, Taylor R, Miller, Crystal M, Cheng, Paul J, Graham, Leah C, Bemiller, Shane, Broihier, Margaret L, Xu, Guixiang, Margevicius, Daniel, Karlo, J Colleen, Sousa, Gregory L, Cotleur, Anne C, Butovsky, Oleg, Bekris, Lynn, Staugaitis, Susan M, Leverenz, James B, Pimplikar, Sanjay W, Landreth, Gary E, Howell, Gareth R, Ransohoff, Richard M, Lamb, Bruce T

“…Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer's disease (AD) and other neurodegenerative diseases…”
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APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction by Soto, Ileana, Graham, Leah C, Richter, Hannah J, Simeone, Stephen N, Radell, Jake E, Grabowska, Weronika, Funkhouser, W Keith, Howell, Megan C, Howell, Gareth R

“…Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related…”
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Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease by Graham, Leah C., Harder, Jeffrey M., Soto, Ileana, de Vries, Wilhelmine N., John, Simon W. M., Howell, Gareth R.

“…Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and…”
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Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity by Yang, Hongtian, Graham, Leah C, Reagan, Alaina M, Grabowska, Weronika A, Schott, William H, Howell, Gareth R

“…Environmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and…”
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Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice by Foley, Kate E, Yang, Hongtian Stanley, Graham, Leah C, Howell, Gareth R

“…The incidence of dementia and cognitive decline is increasing with no therapy or cure. One of the reasons treatment remains elusive is because there are…”
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DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease by Jackson, Harriet M, Onos, Kristen D, Pepper, Keating W, Graham, Leah C, Akeson, Ellen C, Byers, Candice, Reinholdt, Laura G, Frankel, Wayne N, Howell, Gareth R

“…Alzheimer's disease (AD) is a leading cause of dementia in the elderly and is characterized by amyloid plaques, neurofibrillary tangles (NFTs) and neuronal…”
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Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease by Jackson, Harriet M, Soto, Ileana, Graham, Leah C, Carter, Gregory W, Howell, Gareth R

“…Alzheimer's disease affects more than 35 million people worldwide but there is no known cure. Age is the strongest risk factor for Alzheimer's disease but it…”
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The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome by Guedj, Faycal, Pennings, Jeroen L. A., Ferres, Millie A., Graham, Leah C., Wick, Heather C., Miczek, Klaus A., Slonim, Donna K., Bianchi, Diana W.

“…Human fetuses with Down syndrome demonstrate abnormal brain growth and reduced neurogenesis. Despite the prenatal onset of the phenotype, most therapeutic…”
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Exercise prevents obesity-induced cognitive decline and white matter damage in mice by Graham, Leah C., Grabowska, Weronika A., Chun, Yoona, Risacher, Shannon L., Philip, Vivek M., Saykin, Andrew J., Sukoff Rizzo, Stacey J., Howell, Gareth R.

“…Obesity in the western world has reached epidemic proportions, and yet the long-term effects on brain health are not well understood. To address this, we…”
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The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice by Reagan, Alaina M, Christensen, Karen E, Graham, Leah C, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Figueiredo, Lucas L, Persohn, Scott C, Bottiglieri, Teodoro, Nho, Kwangsik, Sasner, Michael, Territo, Paul R, Rozen, Rima, Howell, Gareth R

“…Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer’s disease and related dementias (ADRDs) are increasing; however,…”
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Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice by Howell, Gareth R, Soto, Ileana, Ryan, Margaret, Graham, Leah C, Smith, Richard S, John, Simon W M

“…Glaucoma is an age-related neurodegenerative disorder involving the loss of retinal ganglion cells (RGCs), which results in blindness. Studies in animal models…”
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Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity by Graham, Leah C, Kocalis, Heidi E, Soto, Ileana, Howell, Gareth R

“…Age-related cognitive decline and many dementias involve complex interactions of both genetic and environmental risk factors. Recent evidence has demonstrated…”
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Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer’s disease by Soto, Ileana, Grabowska, Weronika A, Onos, Kristen D, Graham, Leah C, Jackson, Harriet M, Simeone, Stephen N, Howell, Gareth R

“…Abstract Evidence suggests that multiple genetic and environmental factors conspire together to increase susceptibility to Alzheimer’s disease (AD). The…”
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The Maine Cancer Genomics Initiative: Implementing a Community Cancer Genomics Program Across an Entire Rural State by Rueter, Jens, Anderson, Eric C, Graham, Leah C, Antov, Andrey, Helbig, Petra, Gaitor, Lory, Bourne, Jennifer, Edelman, Emily, Reed, E Kate, Reddi, Honey V, Mockus, Susan, DiPalazzo, John, Lu-Emerson, Christine, Inhorn, Roger, Sinclair, Sarah J, Thomas, Christian A, Brooks, Philip L, Rasmussen, Karen, Han, Paul, Liu, Edison T

“…The Maine Cancer Genomics Initiative (MCGI) aimed to overcome patient- and provider-level barriers to using genomic tumor testing (GTT) in rural practices by…”
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APOE stabilization by exercise prevents aging eurovascular dysfunction and complement induction by Soto, Ileana, Graham, Leah C, Richter, Hannah J, Simeone, Stephen N, Radell, Jake E, Grabowska, Weronika, Funkhouser, W. Keith, Howell, Megan C, Howell, Gareth R

“…Aging is the major risk factor for neurodegenerativa diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related…”
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APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction: e1002279 by Soto, Ileana, Graham, Leah C, Richter, Hannah J, Simeone, Stephen N, Radell, Jake E, Grabowska, Weronika, Funkhouser, W Keith, Howell, Megan C, Howell, Gareth R

“…Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related…”
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Investigating the Role of Diet and Exercise on Age-Related Neuroinflammation and Neuronal Health by Graham, Leah C

“…Age-related cognitive decline and neurodegenerative diseases such as Alzheimer’s disease (AD) involve complex interaction of both genetic and environmental…”
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DBA/2J Genetic Background Exacerbates Spontaneous Lethal Seizures but Lessens Amyloid Deposition in a Mouse Model of Alzheimer's Disease: e0125897 by Jackson, Harriet M, Onos, Kristen D, Pepper, Keating W, Graham, Leah C, Akeson, Ellen C, Byers, Candice, Reinholdt, Laura G, Frankel, Wayne N, Howell, Gareth R

“…Alzheimer's disease (AD) is a leading cause of dementia in the elderly and is characterized by amyloid plaques, neurofibrillary tangles (NFTs) and neuronal…”
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