Search Results - "Graham, Galyna V."

Role of exendin‐4 in the Gila monster: Further lessons regarding human oral glucagon‐like peptide‐1 therapy? by Graham, Galyna V., McLaughlin, Chris M., Flatt, Peter R.

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Glucagon from the phylogenetically ancient paddlefish provides a template for the design of a long-acting peptide with effective anti-diabetic and anti-obesity activities by Graham, Galyna V., Conlon, J. Michael, Abdel-Wahab, Yasser H., Flatt, Peter R.

“…This study has examined the in vitro and in vivo anti-diabetic properties of the peptidase-resistant analogues [D-Ser2]palmitoyl-paddlefish glucagon and…”
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Glucagon-related peptides from phylogenetically ancient fish reveal new approaches to the development of dual GCGR and GLP1R agonists for type 2 diabetes therapy by Graham, Galyna V., Conlon, J. Michael, Abdel-Wahab, Yasser H., Flatt, Peter R.

“…•Glucagons and oxyntomodulins from phylogenetic ancient fish stimulate insulin release from clonal β-cells and mouse islets.•Insulinotropic activities of…”
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Glucagon-like peptides-1 from phylogenetically ancient fish show potent anti-diabetic activities by acting as dual GLP1R and GCGR agonists by Graham, Galyna V., Conlon, J. Michael, Abdel-Wahab, Yasser H., Flatt, Peter R.

“…Glucagon-like peptides-1 (GLP-1)from phylogenetically ancient fish (lamprey, dogfish, ratfish, paddlefish and bowfin) and from a teleost, the rainbow trout…”
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A long-acting, dual-agonist analogue of lamprey GLP-1 shows potent insulinotropic, β-cell protective, and anorexic activities and improves glucose homeostasis in high fat-fed mice by Graham, Galyna V., McCloskey, Andrew, Abdel-Wahab, Yasser H., Conlon, J. Michael, Flatt, Peter R.

“…Peptidase-resistant analogues of GLP-1 peptides from sea lamprey and paddlefish ([D-Ala2]palmitoyl-lamprey GLP-1 and [D-Ala2]palmitoyl-paddlefish GLP-1)…”
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Evaluation of the insulinotropic and glucose-lowering actions of zebrafish GIP in mammalian systems: Evidence for involvement of the GLP-1 receptor by Graham, Galyna V., Conlon, J. Michael, Abdel-Wahab, Yasser H., Gault, Victor A., Flatt, Peter R.

“…•zfGIP stimulates insulin release from clonal β-cells and mouse islets.•zfGIP administration improves glucose tolerance in mice.•Insulin release from BRIN-BD11…”
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Effects of long‐acting analogues of lamprey GLP‐1 and paddlefish glucagon on alpha‐ to beta‐cell transdifferentiation in an insulin‐deficient transgenic mouse model by Graham, Galyna V., Conlon, J. Michael, Moffett, R. Charlotte, Abdel‐Wahab, Yasser H., Flatt, Peter R.

“…The abilities of the long‐acting, dual‐agonist anti‐diabetic peptides [D‐Ala2]palmitoyl‐lamprey GLP‐1 and [D‐Ser2]palmitoyl‐paddlefish glucagon to induce…”
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