Search Results - "Graham, G J"

Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis by Leighton, S P, Nerurkar, L, Krishnadas, R, Johnman, C, Graham, G J, Cavanagh, J

“…Inflammatory illness is associated with depression. Preclinical work has shown that chemokines are linked with peripheral–central crosstalk and may be…”
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Suppression, subversion and escape: the role of regulatory T cells in cancer progression by Oleinika, K., Nibbs, R. J., Graham, G. J., Fraser, A. R.

“…Summary Regulatory T cells (Tregs) are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral tolerance…”
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Advancing islet transplantation: from engraftment to the immune response by Gibly, R. F., Graham, J. G., Luo, X., Lowe, W. L., Hering, B. J., Shea, L. D.

“…The promise and progress of islet transplantation for treating type 1 diabetes has been challenged by obstacles to patient accessibility and long-term graft…”
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Enhancing Human Islet Transplantation by Localized Release of Trophic Factors From PLG Scaffolds by Hlavaty, K. A., Gibly, R. F., Zhang, X., Rives, C. B., Graham, J. G., Lowe, W. L., Luo, X., Shea, L. D.

“…Islet transplantation represents a potential cure for type 1 diabetes, yet the clinical approach of intrahepatic delivery is limited by the microenvironment…”
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One motif to bind them: A small-XXX-small motif affects transmembrane domain 1 oligomerization, function, localization, and cross-talk between two yeast GPCRs by Lock, Antonia, Forfar, Rachel, Weston, Cathryn, Bowsher, Leo, Upton, Graham J.G., Reynolds, Christopher A., Ladds, Graham, Dixon, Ann M.

“…G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors in mammals and facilitate a range of physiological responses triggered by…”
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Plants used against cancer – an extension of the work of Jonathan Hartwell by Graham, J.G., Quinn, M.L., Fabricant, D.S., Farnsworth, N.R.

“…A survey of plants used ethnomedically against cancer was undertaken, using the NAPRALERT database currently maintained by the Program for Collaborative…”
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Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies by Vohra, Shabana, Taddese, Bruck, Conner, Alex C., Poyner, David R., Hay, Debbie L., Barwell, James, Reeves, Philip J., Upton, Graham J. G., Reynolds, Christopher A.

“…Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has…”
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Motif effects in Affymetrix GeneChips seriously affect probe intensities by Upton, Graham J G, Harrison, Andrew P

“…An Affymetrix GeneChip consists of an array of hundreds of thousands of probes (each a sequence of 25 bases) with the probe values being used to infer the…”
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Normalized Affymetrix expression data are biased by G-quadruplex formation by Shanahan, Hugh P, Memon, Farhat N, Upton, Graham J G, Harrison, Andrew P

“…Probes with runs of four or more guanines (G-stacks) in their sequences can exhibit a level of hybridization that is unrelated to the expression levels of the…”
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Probes containing runs of guanines provide insights into the biophysics and bioinformatics of Affymetrix GeneChips by Langdon, William B., Upton, Graham J. G., Harrison, Andrew P.

“…The reliable interpretation of Affymetrix GeneChip data is a multi-faceted problem. The interplay between biophysics, bioinformatics and mining of GeneChip…”
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UK catchment nutrient loads 1993-2003, a new approach using harmonised monitoring scheme data: temporal changes, geographical distribution, limiting nutrients and loads to coastal waters by Earl, Timothy J, Upton, Graham J G, Nedwell, David B

“…The work provides robust estimates of nutrient loads (nitrate and phosphate) from all UK catchments: as required by the Water Framework Directive to monitor…”
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Dimerization of G-Protein-Coupled Receptors by Dean, Mark K, Higgs, Christopher, Smith, Richard E, Bywater, Robert P, Snell, Christopher R, Scott, Paul D, Upton, Graham J. G, Howe, Trevor J, Reynolds, Christopher A

“…The evolutionary trace (ET) method, a data mining approach for determining significant levels of amino acid conservation, has been applied to over 700 aligned…”
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Antisense suppression of the small chloroplast protein CP12 in tobacco: A transcriptional viewpoint by Howard, Thomas P., Upton, Graham J. G., Lloyd, Julie C., Raines, Christine A.

“…The chloroplast protein CP12 forms a multi-enzyme complex with the Calvin-Benson cycle enzymes phosphoribulokinase (PRK) and NADP-glyceraldehyde-3-phosphate…”
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Projected expansion of Trichodesmium’s geographical distribution and increase in growth potential in response to climate change by Boatman, Tobias G., Upton, Graham J. G., Lawson, Tracy, Geider, Richard J.

“…Estimates of marine N2 fixation range from 52 to 73 Tg N/year, of which we calculate up to 84% is from Trichodesmium based on previous measurements of nifH…”
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The biochemistry and biology of the atypical chemokine receptors by Graham, G.J, Locati, M, Mantovani, A, Rot, A, Thelen, M

“…Highlights ► This review discusses the members of the ‘atypical’ chemokine receptor family. ► Atypical chemokine receptors have evolved to perform distinct…”
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An overview of image-processing methods for Affymetrix GeneChips by Arteaga-Salas, Jose M., Zuzan, Harry, Langdon, William B., Upton, Graham J. G., Harrison, Andrew P.

“…We present an overview of image-processing methods for Affymetrix GeneChips. All GeneChips are affected to some extent by spatially coherent defects and image…”
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Nasal Polyposis in Children with Cystic Fibrosis: A Long-Term Follow-up Study by Yung, Matthew W., Gould, Jim, Upton, Graham J. G.

“…The incidence of nasal polyposis among children 5 to 18 years of age with cystic fibrosis (CF) was investigated with a systematic examination of all children…”
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Oligonucleotide arrays: information from replication and spatial structure by Upton, Graham J. G., Lloyd, Julie C.

“…Motivation: The introduction of oligonucleotide DNA arrays has resulted in much debate concerning appropriate models for the measurement of gene expression. By…”
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A limited temporal window for the derivation of multilineage repopulating hematopoietic progenitors during embryonal stem cell differentiation in vitro by HOLE, N, GRAHAM, G. J, MENZEL, U, ANSELL, J. D

“…Embryonal stem cells have been shown to differentiate in vitro into all hematopoietic lineages. This has been used successfully as one approach to the study of…”
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Identification and characterization of an inhibitor of haemopoietic stem cell proliferation by Graham, G. J, Wright, E. G, Hewick, R, Wolpe, S. D, Wilkie, N. M, Donaldson, D, Lorimore, S, Pragnell, I. B

“…The haemopoietic system has three main compartments: multi-potential stem cells, intermediate stage progenitor cells and mature cells. The availability of…”
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