Search Results - "Graham, D. G."

The Lipid Peroxidation Product 4‐Hydroxynonenal Inhibits Neurite Outgrowth, Disrupts Neuronal Microtubules, and Modifies Cellular Tubulin by Neely, M. D., Sidell, K. R., Graham, D. G., Montine, T. J.

“…: Oxidative stress is believed to be an important factor in the development of age‐related neurodegenerative diseases such as Alzheimer's disease (AD). The CNS…”
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Parkinson's Disease Is Associated with Oxidative Damage to Cytoplasmic DNA and RNA in Substantia Nigra Neurons by Zhang, Jing, Perry, George, Smith, Mark A., Robertson, David, Olson, Sandra J., Graham, Doyle G., Montine, Thomas J.

“…Oxidative damage, including modification of nucleic acids, may contribute to dopaminergic neurodegeneration in the substantia nigra (SN) of patients with…”
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Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4 by Montine, KS, Olson, SJ, Amarnath, V, Whetsell, WO, Jr, Graham, DG, Montine, TJ

“…Cumulative oxidative damage, including lipid peroxidation, is a central component of cellular aging and is thought to play a role in the pathogenesis of…”
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E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures by Montine, TJ, Amarnath, V, Martin, ME, Strittmatter, WJ, Graham, DG

“…Lipid peroxidation increases with age in brain and is elevated further in Alzheimer's disease. E-4-hydroxy-2-nonenal and malondialdehyde are products of lipid…”
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4‐Hydroxy‐2(E)‐Nonenal Inhibits CNS Mitochondrial Respiration at Multiple Sites by Picklo, Matthew J., Amarnath, Venkataraman, McIntyre, J. Oliver, Graham, Doyle G., Montine, Thomas J.

“…: A destructive cycle of oxidative stress and mitochondrial dysfunction is proposed in neurodegenerative disease. Lipid peroxidation, one outcome of oxidative…”
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Enhanced N-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Toxicity in Mice Deficient in CuZn-Superoxide Dismutase or Glutathione Peroxidase by ZHANG, JING, GRAHAM, DOYLE G, MONTINE, THOMAS J, HO, YE-SHIH

“…Administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mammals causes damage to the nigrostriatal dopaminergic pathway similar to that…”
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Neurotoxicity of Endogenous Cysteinylcatechols by Montine, T.J., Picklo, M.J., Amarnath, V., Whetsell, W.O., Graham, D.G.

“…Progression of Parkinson's disease has been associated with several biochemical changes in the substantia nigra including increased oxidative challenge,…”
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Quinone chemistry and toxicity by Monks, T J, Hanzlik, R P, Cohen, G M, Ross, D, Graham, D G

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Spectroscopic imaging of stroke in humans : histopathology correlates of spectral changes by PETROFF, O. A. C, GRAHAM, G. D, BLAMIRE, A. M, AL-RAYESS, M, ROTHMAN, D. L, FAYAD, P. B, BRASS, L. M, SHULMAN, R. G, PRICHARD, J. W

“…Previous studies of human stroke by 1H nuclear magnetic resonance spectroscopy have shown elevation of lactate lasting 3 to 6 months. Complete metabolic…”
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Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients by GRAHAM, G. D, BLAMIRE, A. M, HOWSEMAN, A. M, ROTHMAN, D. L, FAYAD, P. B, BRASS, L. M, PETROFF, O. A. C, SHULMAN, R. G, PRICHARD, J. W

“…Proton magnetic resonance spectroscopy can measure in vivo brain lactate and other metabolites noninvasively. We measured the biochemical changes accompanying…”
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Influence of clostridial vaccines and injection sites on performance, feeding behavior, and lesion size scores of beef steers by Chirase, N. K, Greene, L. W, Graham, G. D, Avampato, J. M

“…Several clostridial vaccines are currently being used in the beef cattle industry. Of greatest concern is altering the location and route of administration of…”
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Thinking outside the box: Aboriginal people’s suggestions for conducting health studies with Aboriginal communities by Maar, M.A, Lightfoot, N.E, Sutherland, M.E, Strasser, R.P, Wilson, K.J, Lidstone-Jones, C.M, Graham, D.G, Beaudin, R, Daybutch, G.A, Dokis, B.R, Lesage, M.T, Raymond, M, Williamson, P

“…Summary Objectives Aboriginal people are under-represented in epidemiological research, largely due to past failures to engage and recruit Aboriginal…”
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The Measurement of 2-Thiothiazolidine-4-carboxylic Acid as an Index of the in Vivo Release of CS2 by Dithiocarbamates by Johnson, D. J, Graham, D. G, Amarnath, V, Amarnath, K, Valentine, W. M

“…Dithiocarbamates and their disulfides are used extensively as agricultural fungicides, as accelerators of the vulcanization process of rubber in industry, and…”
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Characterization of Carbon Disulfide Neurotoxicity in C57BL6 Mice: Behavioral, Morphologic, and Molecular Effects by Sills, R.C., Valentine, W.M., Moser, V., Graham, D.G., Morgan, D.L.

“…Female C57BL6 mice were exposed to 0 or 800 ppm carbon disulfide (CS2), 6 h/d, 5 d/wk for 20 weeks. The neurologic function of all mice was assessed once at…”
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Learning the hard way: the importance of accurate data by Lewis, R. S., Graham, D. G., Watson, J. D., Lunniss, P. J.

“…Aim  The outcome of surgery for colorectal cancer in each unit in the UK is collated by the National Bowel Cancer Audit Project (NBOCAP). In 2008–2009 our unit…”
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Catecholamine toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's disease by Graham, D G

“…An hypothesis is presented which attempts to relate the pathogenesis of both manganese neurotoxicity and Parkinson's disease to cytotoxicity from products of…”
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Release of carbon disulfide is a contributing mechanism in the axonopathy produced by N,N-diethyldithiocarbamate by Johnson, D J, Graham, D G, Amarnath, V, Amarnath, K, Valentine, W M

“…The neurotoxicity of N,N-diethyldithiocarbamate (DEDC) is established, although the mechanisms responsible for its neurotoxicity are not. Previous experiments…”
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Enhancement of dopaminergic neurotoxicity by the mercapturate of dopamine : Relevance to Parkinson's disease by JING ZHANG, KRAVTSOV, V, AMARNATH, V, PICKLO, M. J, GRAHAM, D. G, MONTINE, T. J

“…The mechanisms that underlie dopaminergic neurodegeneration in Parkinson's disease (PD) are not known but have been proposed to involve oxidation of dopamine…”
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Clinical correlates of proton magnetic resonance spectroscopy findings after acute cerebral infarction by GRAHAM, G. D, KALVACH, P, BLAMIRE, A. M, BRASS, L. M, FAYAD, P. B, PRICHARD, J. W

“…We sought to determine whether lactate and N-acetyl signals measured by proton magnetic resonance spectroscopy (MRS) in the first days after stroke correlate…”
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Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain by Hwang, J H, Graham, G D, Behar, K L, Alger, J R, Prichard, J W, Rothman, D L

“…A novel approach is presented for imaging macromolecule and metabolite signals in brain by proton magnetic resonance spectroscopic imaging. The method…”
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