Search Results - "Graham, Brett A"

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia by Boyle, Kieran A, Gradwell, Mark A, Yasaka, Toshiharu, Dickie, Allen C, Polgár, Erika, Ganley, Robert P, Orr, Desmond P H, Watanabe, Masahiko, Abraira, Victoria E, Kuehn, Emily D, Zimmerman, Amanda L, Ginty, David D, Callister, Robert J, Graham, Brett A, Hughes, David I

“…Chronic pain presents a major unmet clinical problem. The development of more effective treatments is hindered by our limited understanding of the neuronal…”
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The role of propriospinal interneurons in recovery from spinal cord injury by Flynn, Jamie R., Graham, Brett A., Galea, Mary P., Callister, Robert J.

“…Over one hundred years ago, Sir Charles Sherrington described a population of spinal cord interneurons (INs) that connect multiple spinal cord segments and…”
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Lateral lamina V projection neuron axon collaterals connect sensory processing across the dorsal horn of the mouse spinal cord by Browne, Tyler J., Smith, Kelly M., Gradwell, Mark A., Dayas, Christopher V., Callister, Robert J., Hughes, David I., Graham, Brett A.

“…Spinal projection neurons (PNs) are defined by long axons that travel from their origin in the spinal cord to the brain where they relay sensory information…”
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Calretinin positive neurons form an excitatory amplifier network in the spinal cord dorsal horn by Smith, Kelly M, Browne, Tyler J, Davis, Olivia C, Coyle, A, Boyle, Kieran A, Watanabe, Masahiko, Dickinson, Sally A, Iredale, Jacqueline A, Gradwell, Mark A, Jobling, Phillip, Callister, Robert J, Dayas, Christopher V, Hughes, David I, Graham, Brett A

“…Nociceptive information is relayed through the spinal cord dorsal horn, a critical area in sensory processing. The neuronal circuits in this region that…”
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Calretinin-expressing islet cells are a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord by Davis, Olivia C., Dickie, Allen C., Mustapa, Marami B., Boyle, Kieran A., Browne, Tyler J., Gradwell, Mark A., Smith, Kelly M., Polgár, Erika, Bell, Andrew M., Kókai, Éva, Watanabe, Masahiko, Wildner, Hendrik, Zeilhofer, Hanns Ulrich, Ginty, David D., Callister, Robert J., Graham, Brett A., Todd, Andrew J., Hughes, David I.

“…Unmyelinated non-peptidergic nociceptors (NP afferents) arborise in lamina II of the spinal cord and receive GABAergic axoaxonic synapses, which mediate…”
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Projection Neuron Axon Collaterals in the Dorsal Horn: Placing a New Player in Spinal Cord Pain Processing by Browne, Tyler J, Hughes, David I, Dayas, Christopher V, Callister, Robert J, Graham, Brett A

“…The pain experience depends on the relay of nociceptive signals from the spinal cord dorsal horn to higher brain centers. This function is ultimately achieved…”
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A systematic review of the evidence for central nervous system plasticity in animal models of inflammatory-mediated gastrointestinal pain by Farrell, Kristen E, Keely, Simon, Graham, Brett A, Callister, Robin, Callister, Robert J

“…Abdominal pain frequently accompanies inflammatory disorders of the gastrointestinal tract (GIT), and animal models of GIT inflammation have been developed to…”
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Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls by Yeoh, Jiann Wei, Campbell, Erin J, James, Morgan H, Graham, Brett A, Dayas, Christopher V

“…The tight regulation of sleep/wake states is critical for mental and physiological wellbeing. For example, dysregulation of sleep/wake systems predisposes…”
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Increased white matter neuron density in a rat model of maternal immune activation — Implications for schizophrenia by Duchatel, Ryan J., Jobling, Phillip, Graham, Brett A., Harms, Lauren R., Michie, Patricia T., Hodgson, Deborah M., Tooney, Paul A.

“…Interstitial neurons are located among white matter tracts of the human and rodent brain. Post-mortem studies have identified increased interstitial white…”
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Cocaine potentiates excitatory drive in the perifornical/lateral hypothalamus by Yeoh, Jiann Wei, James, Morgan H., Jobling, Phillip, Bains, Jaideep S., Graham, Brett A., Dayas, Christopher V.

“…Key points •  Drugs of addiction are well‐established in their capacity to alter brain reward pathways. •  The perifornical/lateral hypothalamus has previously…”
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Altered Intrinsic Properties and Inhibitory Connectivity in Aged Parvalbumin-Expressing Dorsal Horn Neurons by Gradwell, Mark A., Smith, Kelly M., Dayas, Christopher V., Smith, Douglas W., Hughes, David I., Callister, Robert J., Graham, Brett A.

“…The incidence of pain symptoms such as allodynia are known to increase with age. Parvalbumin expressing interneurons (PVINs) within the dorsal horn (DH) of the…”
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Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive by Mitchell, Caitlin S., Campbell, Erin J., Fisher, Simon D., Stanton, Laura M., Burton, Nicholas J., Pearl, Amy J., McNally, Gavan P., Bains, Jaideep S., Füzesi, Tamás, Graham, Brett A., Manning, Elizabeth E., Dayas, Christopher V.

“…Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like…”
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Transgenic Cross-Referencing of Inhibitory and Excitatory Interneuron Populations to Dissect Neuronal Heterogeneity in the Dorsal Horn by Browne, Tyler J, Gradwell, Mark A, Iredale, Jacqueline A, Madden, Jessica F, Callister, Robert J, Hughes, David I, Dayas, Christopher V, Graham, Brett A

“…The superficial dorsal horn (SDH, LI-II) of the spinal cord receives and processes multimodal sensory information from skin, muscle, joints, and viscera then…”
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Functional and Molecular Analysis of Proprioceptive Sensory Neuron Excitability in Mice by Madden, Jessica F., Davis, Olivia C., Boyle, Kieran A., Iredale, Jacqueline A., Browne, Tyler J., Callister, Robert J., Smith, Douglas W., Jobling, Phillip, Hughes, David I., Graham, Brett A.

“…Neurons located in dorsal root ganglia (DRG) are crucial for transmitting peripheral sensations such as proprioception, touch, temperature and nociception to…”
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Gabapentin Modulates HCN4 Channel Voltage-Dependence by Tae, Han-Shen, Smith, Kelly M, Phillips, A Marie, Boyle, Kieran A, Li, Melody, Forster, Ian C, Hatch, Robert J, Richardson, Robert, Hughes, David I, Graham, Brett A, Petrou, Steven, Reid, Christopher A

“…Gabapentin (GBP) is widely used to treat epilepsy and neuropathic pain. There is evidence that GBP can act on hyperpolarization-activated cation (HCN)…”
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Defining populations of dorsal horn interneurons by Graham, Brett A., Hughes, David I.

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Cervix Stimulation Evokes Predominantly Subthreshold Synaptic Responses in Mouse Thoracolumbar and Lumbosacral Superficial Dorsal Horn Neurons by Jobling, Phillip, Graham, Brett A., Brichta, Alan M., Callister, Robert J.

“…Sensory input from the female reproductive tract (FRT) plays a pivotal role in coordinating reproductive reflexes. Additionally, a number of disorders,…”
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Progressing into a new paradigm: how we must leave the past behind if we want a change in pain research outcomes by Russo, Marc A, Santarelli, Danielle M, Austin, Paul J, Graham, Brett A

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Different Forms of Glycine- and GABAA-Receptor Mediated Inhibitory Synaptic Transmission in Mouse Superficial and Deep Dorsal Horn Neurons by Anderson, Wayne B, Graham, Brett A, Beveridge, Natalie J, Tooney, Paul A, Brichta, Alan M, Callister, Robert J

“…Background Neurons in superficial (SDH) and deep (DDH) laminae of the spinal cord dorsal horn receive sensory information from skin, muscle, joints and…”
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The search for novel analgesics: re-examining spinal cord circuits with new tools by Smith, Kelly M, Madden, Jessica F, Callister, Robert J, Hughes, David I, Graham, Brett A

“…In this perspective, we propose the absence of detailed information regarding spinal cord circuits that process sensory information remains a major barrier to…”
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