Search Results - "Grage, Stephan L."
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Room-Temperature High-Efficiency Solid-State Triplet–Triplet Annihilation Up-Conversion in Amorphous Poly(olefin sulfone)s
Published in ACS applied materials & interfaces (08-03-2017)“…Triplet–triplet annihilation up-conversion (TTA-UC) is a developing technology that can enable spectral conversion under sunlight. Previously, it was found…”
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Probing and Manipulating the Lateral Pressure Profile in Lipid Bilayers Using Membrane-Active Peptides—A Solid-State 19F NMR Study
Published in International journal of molecular sciences (20-04-2022)“…The lateral pressure profile constitutes an important physical property of lipid bilayers, influencing the binding, insertion, and function of membrane-active…”
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Folding and Self-Assembly of the TatA Translocation Pore Based on a Charge Zipper Mechanism
Published in Cell (17-01-2013)“…We propose a concept for the folding and self-assembly of the pore-forming TatA complex from the Twin-arginine translocase and of other membrane proteins based…”
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Transient Potential Gradients and Impedance Measures of Tethered Bilayer Lipid Membranes: Pore-Forming Peptide Insertion and the Effect of Electroporation
Published in Biophysical journal (07-01-2014)“…In this work, we present experimental data, supported by a quantitative model, on the generation and effect of potential gradients across a tethered bilayer…”
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Membrane Alignment of the Pore-Forming Component TatAd of the Twin-Arginine Translocase from Bacillus subtilis Resolved by Solid-State NMR Spectroscopy
Published in Journal of the American Chemical Society (17-11-2010)“…The twin-arginine translocase (Tat) provides protein export in bacteria and plant chloroplasts and is capable of transporting fully folded proteins across the…”
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Membrane Thinning and Thickening Induced by Membrane-Active Amphipathic Peptides
Published in Frontiers in cell and developmental biology (24-06-2016)“…Membrane thinning has been discussed as a fundamental mechanism by which antimicrobial peptides can perturb cellular membranes. To understand which factors…”
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Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor
Published in Biophysical journal (18-08-2015)“…The oncogenic E5 protein from bovine papillomavirus is a short (44 amino acids long) integral membrane protein that forms homodimers. It activates…”
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Bilayer-Mediated Clustering and Functional Interaction of MscL Channels
Published in Biophysical journal (02-03-2011)“…Mechanosensitive channels allow bacteria to respond to osmotic stress by opening a nanometer-sized pore in the cellular membrane. Although the underlying…”
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Action of the multifunctional peptide BP100 on native biomembranes examined by solid-state NMR
Published in Journal of biomolecular NMR (01-04-2015)“…Membrane composition is a key factor that regulates the destructive activity of antimicrobial peptides and the non-leaky permeation of cell penetrating…”
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Magnetically oriented dodecylphosphocholine bicelles for solid-state NMR structure analysis
Published in Biochimica et biophysica acta (01-05-2012)“…A mixture of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) with the short-chain detergent n-dodecylphosphocholine (DPC) is introduced here as a new…”
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Tough, Transparent, 3D‐Printable, and Self‐Healing Poly(ethylene glycol)‐Gel (PEGgel)
Published in Advanced materials (Weinheim) (01-03-2022)“…Polymer gels, such as hydrogels, have been widely used in biomedical applications, flexible electronics, and soft machines. Polymer network design and its…”
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Canonical Azimuthal Rotations and Flanking Residues Constrain the Orientation of Transmembrane Helices
Published in Biophysical journal (02-04-2013)“…In biological membranes the alignment of embedded proteins provides crucial structural information. The transmembrane (TM) parts have well-defined secondary…”
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Membrane-Mediated Activity of Local Anesthetics
Published in Molecular pharmacology (01-11-2021)Get full text
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Bilayer thickness determines the alignment of model polyproline helices in lipid membranes
Published in Physical chemistry chemical physics : PCCP (16-10-2019)“…Our understanding of protein folds relies fundamentally on the set of secondary structures found in the proteomes. Yet, there also exist intriguing structures…”
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Correlation between Macroscopic Elasticity and Chain Dynamics of Natural Rubber during Vulcanization as Determined by a Unique Rheo-NMR Combination
Published in Macromolecules (13-07-2021)“…The cross-linking process of natural rubber (NR) is studied for the first time by a unique combination of rheology and time-domain (TD) NMR, two methods that…”
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Biocompatibility of Amine‐Functionalized Silica Nanoparticles: The Role of Surface Coverage
Published in Small (Weinheim an der Bergstrasse, Germany) (01-03-2019)“…Here, amorphous silica nanoparticles (NPs), one of the most abundant nanomaterials, are used as an example to illustrate the utmost importance of surface…”
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Spiropyran‐Based Photoisomerizable α‐Amino Acid for Membrane‐Active Peptide Modification
Published in Chemistry : a European journal (16-04-2024)“…Photoisomerizable peptides are promising drug candidates in photopharmacology. While azobenzene‐ and diarylethene‐containing photoisomerizable peptides have…”
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Transmembrane Polyproline Helix
Published in The journal of physical chemistry letters (03-05-2018)“…The third most abundant polypeptide conformation in nature, the polyproline-II helix, is a polar, extended secondary structure with a local organization…”
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Length matters: Functional flip of the short TatA transmembrane helix
Published in Biophysical journal (06-06-2023)“…The twin arginine translocase (Tat) exports folded proteins across bacterial membranes. The putative pore-forming or membrane-weakening component (TatAd in…”
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"Force-from-lipids" gating of mechanosensitive channels modulated by PUFAs
Published in Journal of the mechanical behavior of biomedical materials (01-03-2018)“…The level of fatty acid saturation in phospholipids is a crucial determinant of the biophysical properties of the lipid bilayer. Integral membrane proteins are…”
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