Search Results - "Grafstrom, Robert H"

Identification of Peptide Substrates for Human MMP-11 (Stromelysin-3) Using Phage Display by Pan, Weijun, Arnone, Marc, Kendall, Marvin, Grafstrom, Robert H., Seitz, Steven P., Wasserman, Zelda R., Albright, Charles F.

“…The MMP-11 proteinase, also known as stromelysin-3, probably plays an important role in human cancer because MMP-11 is frequently overexpressed in human tumors…”
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Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3 by Yue, Eddy W, Higley, C. Anne, DiMeo, Susan V, Carini, David J, Nugiel, David A, Benware, Carrie, Benfield, Pamela A, Burton, Catherine R, Cox, Sarah, Grafstrom, Robert H, Sharp, Diane M, Sisk, Lisa M, Boylan, John F, Muckelbauer, Jodi K, Smallwood, Angela M, Chen, Haiying, Chang, Chong-Hwan, Seitz, Steven P, Trainor, George L

“…The identification of indeno[1,2-c]pyrazol-4-ones as inhibitors of cyclin-dependent kinases (CDKs) has led to the discovery of a series of novel and potent…”
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The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression by Burton, Catherine R., Meredith, Jere E., Barten, Donna M., Goldstein, Margi E., Krause, Carol M., Kieras, Cathy J., Sisk, Lisa, Iben, Lawrence G., Polson, Craig, Thompson, Mark W., Lin, Xu-Alan, Corsa, Jason, Fiedler, Tracey, Pierdomenico, Maria, Cao, Yang, Roach, Arthur H., Cantone, Joseph L., Ford, Michael J., Drexler, Dieter M., Olson, Richard E., Yang, Michael G., Bergstrom, Carl P., McElhone, Kate E., Bronson, Joanne J., Macor, John E., Blat, Yuval, Grafstrom, Robert H., Stern, Andrew M., Seiffert, Dietmar A., Zaczek, Robert, Albright, Charles F., Toyn, Jeremy H.

“…The amyloid-β (Aβ) peptide, which likely plays a key role in Alzheimer disease, is derived from the amyloid-β precursor protein (APP) through consecutive…”
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Quinazolines as cyclin dependent kinase inhibitors by Sielecki, Thais M., Johnson, Tricia L., Liu, Jie, Muckelbauer, Jodi K., Grafstrom, Robert H., Cox, Sarah, Boylan, John, Burton, Catherine R., Chen, Haiying, Smallwood, Angela, Chang, Chong-Hwan, Boisclair, Michael, Benfield, Pamela A., Trainor, George L., Seitz, Steven P.

“…Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray…”
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A cyclin D1/cyclin-dependent kinase 4 binding site within the C domain of the retinoblastoma protein by WEIJUN PAN, COX, Sarah, HOESS, Ronald H, GRAFSTRÖM, Robert H

“…Phosphorylation of the retinoblastoma protein (Rb) by the cyclin D1/cyclin-dependent kinase (cdk) 4 complex (cdk4/D1) is a key regulatory step for maintaining…”
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Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3 by Yue, Eddy W., DiMeo, Susan V., Higley, C.Anne, Markwalder, Jay A., Burton, Catherine R., Benfield, Pamela A., Grafstrom, Robert H., Cox, Sarah, Muckelbauer, Jodi K., Smallwood, Angela M., Chen, Haiying, Chang, Chong-Hwan, Trainor, George L., Seitz, Steven P.

“…New indeno[1,2- c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with…”
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Defining the substrate specificity of cdk4 kinase-cyclin D1 complex by GRAFSTROM, R. H, WEIJUN PAN, HOESS, R. H

“…cdk4 kinase-cyclin D1 complex (cdk4/D1) does not phosphorylate all of the sites within retinoblastoma protein (Rb) equally. Comparison of five phosphorylation…”
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Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus by Haseltine, William A, Gordon, Lynn K, Lindan, Christina P, Grafstrom, Robert H, Shaper, Nancy L, Grossman, Lawrence

“…Pyrimidine dimer formation in response to UV radiation is governed by the thymine content of the potential dimer and the two flanking nucleotides. An enzymatic…”
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The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression by Catherine R. Burton, Jere E. Meredith, Donna M. Barten, Margi E. Goldstein, Carol M. Krause, Cathy J. Kieras, Lisa Sisk, Lawrence G. Iben, Craig Polson, Mark W. Thompson, Xu-Alan Lin, Jason Corsa, Tracey Fiedler, Maria Pierdomenico, Yang Cao, Arthur H. Roach, Joseph L. Cantone, Michael J. Ford, Dieter M. Drexler, Richard E. Olson, Michael G. Yang, Carl P. Bergstrom, Kate E. McElhone, Joanne J. Bronson, John E. Macor, Yuval Blat, Robert H. Grafstrom, Andrew M. Stern, Dietmar A. Seiffert, Robert Zaczek, Charles F. Albright, Jeremy H. Toyn

“…The amyloid-β (Aβ) peptide, which likely plays a key role in Alzheimer disease, is derived from the amyloid-β precursor protein (APP) through consecutive…”
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The characteristics of DNA methytation in an in vitro DNA synthesizing system from mouse fibroblasts by Grafstrom, Robert H., Yuan, Robert, Hamilton, Daniel L.

“…An in vitro DNA synthesizing system from mouse fibroblasts has been used to study DNA methylation. DNA methylation occurs in two phases, one at the replication…”
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REPETITIOUS SEQUENCES OF DNA. I. TERMINALLY REPETITIOUS SEQUENCES IN HERPES SIMPLEX VIRUS TYPE 1 DNA. II. TANDEMLY REPETITIOUS SEQUENCES IN ESCHERICHIA COLI DNA by GRAFSTROM, ROBERT H

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Mechanism of thymineless death by Goulian, M, Bleile, B M, Dickey, L M, Grafstrom, R H, Ingraham, H A, Neynaber, S A, Peterson, M S, Tseng, B Y

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The incorporation of uracil into animal cell DNA in vitro by Grafstrom, R H, Tseng, B Y, Goulian, M

“…In the presence of dUTP, net DNA synthesis in vitro is substantially reduced. Small DNA fragments that arise during in vitro DNA synthesis in the presence of…”
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Cloning of mutH and identification of the gene product by Grafstrom, R H, Hoess, R H

“…A specialized lambda transducing phage carrying the mutH gene and several deletion derivatives of this phage were characterized by restriction enzyme analysis…”
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The repair of pyrimidine dimers via a DNA-glycosylase mechanism by Grafstrom, R H

“…The "UV endonuclease" isolated either from M. luteus or bacteriophage T4 infected E. coli (the denV gene product) consists of two enzymatic activities on a…”
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Tandem duplications resulting from recombination between ribosomal RNA genes in Escherichia coli by Hill, C W, Grafstrom, R H, Harnish, B W, Hillman, B S

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The terminal repetition of herpes simplex virus DNA by Grafstrom, R H, Alwine, J C, Steinhart, W L, Hill, C W, Hyman, R W

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The DNA binding properties of the MutL protein isolated from Escherichia coli by BENDE, S. M, GRAFSTROÊM, R. H

“…The mutL gene of Escherichia coli, which is involved in the repair of mispaired and unpaired nucleotides in DNA, has been independently cloned and the gene…”
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Terminal fragments of herpes simplex virus DNA produced by restriction endonuclease by Steinhart, W L, Grafstrom, R H, Hill, C W

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