Search Results - "Graff, J R"

Molecular pathways involved in the synergistic interaction of the PKCβ inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells by Tekle, C, Giovannetti, E, Sigmond, J, Graff, J R, Smid, K, Peters, G J

“…Conventional regimens have limited impact against non-small cell lung cancer (NSCLC). Current research is focusing on multiple pathways as potential targets,…”
Get full text

The Clinical Importance of Flow Cytometry Crossmatch in the Context of CDC Crossmatch Results by Graff, R.J, Buchanan, P.M, Dzebisashvili, N, Schnitzler, M.A, Tuttle-Newhall, J, Xiao, H, Schadde, E, Gheorghian, A, Lentine, K.L

“…Abstract Background The complement-dependent microcytotoxicity crossmatch (CDCXM) is a standard method for evaluating the presence of preformed antibodies…”
Get full text

Antisense oligonucleotide targeting eukaryotic translation initiation factor 4E reduces growth and enhances chemosensitivity of non-small-cell lung cancer cells by Thumma, S C, Jacobson, B A, Patel, M R, Konicek, B W, Franklin, M J, Jay-Dixon, J, Sadiq, A, De, A, Graff, J R, Kratzke, R A

“…Elevated levels of eukaryotic translation initiation factor 4E (eIF4E) enhance translation of many malignancy-related proteins, such as vascular endothelial…”
Get full text

Methylation-Specific PCR: A Novel PCR Assay for Methylation Status of CpG Islands by Herman, James G., Graff, Jeremy R., Myöhänen, Sanna, Nelkin, Barry D., Baylin, Stephen B.

“…Precise mapping of DNA methylation patterns in CpG islands has become essential for understanding diverse biological processes such as the regulation of…”
Get full text

Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis by Zimmer, S G, DeBenedetti, A, Graff, J R

“…Recent studies have implicated the mRNA cap-binding protein, eIF-4E, as a key regulator of malignant progression. Indeed, the major intracellular signaling…”
Get more information

Methylation-associated silencing of the tissue inhibitor of Metalloproteinase-3 gene suggests a suppressor role in kidney, brain, and other human cancers by BACHMAN, K. E, HERMAN, J. G, CORN, P. G, MERLO, A, COSTELLO, J. F, CAVENEE, W. K, BAYLIN, S. B, GRAFF, J. R

“…Tissue inhibitor of metalloproteinase-3 (TIMP-3) antagonizes matrix metalloproteinase activity and can suppress tumor growth, angiogenesis, invasion, and…”
Get full text

Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer by NASS, S. J, HERMAN, J. G, GABRIELSON, E, IVERSEN, P. W, PARL, F. F, DAVIDSON, N. E, GRAFF, J. R

“…Loss of expression for both the estrogen receptor-alpha and E-cadherin genes has been linked to disease progression in human ductal breast carcinomas and has…”
Get full text

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas by GRAFF, J. R, HERMAN, J. G, LAPIDUS, R. G, CHOPRA, H, XU, R, JARRARD, D. F, ISAACS, W. B, PITHA, P. M, DAVIDSON, N. E, BAYLIN, S. B

“…Expression of the Ca(2+)-dependent, homotypic cell:cell adhesion molecule, E-cadherin (E-cad), suppresses tumor cell invasion and metastasis in experimental…”
Get full text

Hypomethylation of pericentromeric DNA in breast adenocarcinomas by Narayan, Ajita, Ji, Weizhen, Zhang, Xian‐Yang, Marrogi, Aizen, Graff, Jeremy R., Baylin, Stephen B., Ehrlich, Melanie

“…Drug‐induced DNA demethylation in normal human cells and inherited localized hypomethylation in mitogen‐stimulated lymphocytes from patients with a rare…”
Get full text

Remembrances of George Snell by Graff, R J

Get full text

Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma by GRAFF, J. R, GREENBERG, V. E, HERMAN, J. G, WESTRA, W. H, BOGHAERT, E. R, AIN, K. B, SAJI, M, ZEIGER, M. A, ZIMMER, S. G, BAYLIN, S. B

“…Expression of the invasion/metastasis suppressor, E-cadherin, is diminished or lost in thyroid carcinomas. Yet, mutational inactivation of E-cadherin is rare…”
Get full text

HLA-DQB103 in allergic fungal sinusitis and other chronic hypertrophic rhinosinusitis disorders by SCHUBERT, Mark S, HUTCHESON, Patricia S, GRAFF, Ralph J, SANTIAGO, Luis, SLAVIN, Raymond G

“…Background Many common chronic inflammatory disorders have strong HLA gene associations, particularly with MHC class II. Allergic fungal rhinosinusitis (AFS)…”
Get full text

Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts by Graff, J R, Boghaert, E R, De Benedetti, A, Tudor, D L, Zimmer, C C, Chan, S K, Zimmer, S G

“…Expression of the T24ras oncogene induces malignancy (tumor growth, invasion and metastasis) in cloned rat embryo fibroblasts (CREF T24). In CREF T24, the rate…”
Get more information

Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts by Rinker-Schaeffer, C W, Graff, J R, De Benedetti, A, Zimmer, S G, Rhoads, R E

“…Transformation of cloned rat embryo fibroblasts (CREF) with the T24-ras oncogene results in loss of contact inhibition, growth in soft agar and tumor formation…”
Get more information

Class I and class II antigens in the rejection of murine islet cell transplants by Hauptfeld, V, Lacy, P E, Graff, R J

Get more information

eIF-4E expression and its role in malignancies and metastases by De Benedetti, Arrigo, Graff, Jeremy R

“…The contribution of the mRNA cap-binding protein, eIF-4E, to malignant transformation and progression has been illuminated over the past decade. eIF-4E…”
Get full text

Recognition of the beta-2 microglobulin-B molecule by a CTL clone by Kurtz, ME, Martin-Morgan, D, Graff, RJ

“…In this report we offer evidence that the beta-2 microglobulin-B (beta 2M-B) molecule is recognized by a cytotoxic T lymphocyte (CTL). Production of GA5, a CTL…”
Get full text

Allograft rejection-defined antigens of the B2m,H-3 region by Graff, RJ, Martin-Morgan, D, Kurtz, ME

“…In this report we delineate the production and histocompatibility characteristics of two new B2m, H-3 region congenic strains, B10.SM-a and B10.FS-a, and…”
Get full text

Evidence for triple-junction rifting focussed on local magmatic centres along Parga Chasma, Venus by Graff, J.R., Ernst, R.E., Samson, C.

“…•Parga Chasma features a complex morphology of both local and regional rifting.•Local and regional rifting is revealed to have occurred in two distinct…”
Get full text

CTL and serologically defined antigens of B2m,H-3 region by Kurtz, ME, Graff, RJ, Adelman, A, Martin-Morgan, D, Click, RE

“…The antigens of the B2m,H-3 region of 13 chromosome 2 congenic strains and seven inbred strains have been studied by using CML and serologic techniques. Nine…”
Get full text