Search Results - "Grafe, P"

Chemical mediators enhance the excitability of unmyelinated sensory axons in normal and injured peripheral nerve of the rat by Moalem, G., Grafe, P., Tracey, D.J.

“…Ectopic excitation of nociceptive axons by chemical mediators may contribute to symptoms in neuropathic pain. In this study, we have measured the excitability…”
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Retigabine reduces the excitability of unmyelinated peripheral human axons by Lang, P.M., Fleckenstein, J., Passmore, G.M., Brown, D.A., Grafe, P.

“…Enhancement of membrane K + conductance may reduce the abnormal excitability of primary afferent nociceptive neurons in neuropathic pain. It has been shown…”
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Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerve by Freysoldt, A, Fleckenstein, J, Lang, PM, Irnich, D, Grafe, P, Carr, RW

“…Background and purpose:  Amitriptyline is often prescribed as a first‐line treatment for neuropathic pain but its precise mode of analgesic action remains…”
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Characterization of Neuronal Nicotinic Acetylcholine Receptors in the Membrane of Unmyelinated Human C-Fiber Axons by In Vitro Studies by Lang, P. M, Burgstahler, R, Sippel, W, Irnich, D, Schlotter-Weigel, B, Grafe, P

“…Departments of 1 Physiology and 2 Anesthesiology and 3 Friedrich-Baur-Institute, Ludwig-Maximilians University, 80336 Munich, Germany Submitted 28 May 2003;…”
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185 AMITRIPTYLINE BLOCKS THE DEPOLARISING EFFECT OF NICOTINE IN UNMYELINATED HUMAN AXONS by Carr, R.W., Freysoldt, A., Fleckenstein, J., Lang, P.M., Irnich, D., Grafe, P.

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Kinetics of ATP release following compression injury of a peripheral nerve trunk by Grafe, P, Schaffer, V, Rucker, F

“…Compression and/or contusion of a peripheral nerve trunk can result in painful sensations. It is possible that release of ATP into the extracellular space may…”
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ATP stimulates peripheral axons in human, rat and mouse: Differential involvement of A2B adenosine and P2X purinergic receptors by IRNICH, D, TRACEY, D. J, POLTEN, J, BURGSTAHLER, R, GRAFE, P

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A conus peptide blocks nicotinic receptors of unmyelinated axons in human nerves by Lang, Philip M, Burgstahler, Ralf, Haberberger, Rainer V, Sippel, Wolfgang, Grafe, Peter

“…The novel α-conotoxin Vc1.1 is a potential analgesic for the treatment of painful neuropathic conditions. In the present study, the effects of Vc1.1 were…”
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Function and distribution of three types of rectifying channel in rat spinal root myelinated axons by Baker, M, Bostock, H, Grafe, P, Martius, P

“…1. The nature, distribution and function of rectifying channels in rat spinal root myelinated axons has been assessed with selective blocking agents and a…”
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348 Excitability after the action potential indicates changes in membrane potential of isolated nociceptive C-fibers by Moalem-Taylor, G, Lang, P.M, Tracey, D.J, Grafe, P

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Calcium potentials and tetrodotoxin-resistant sodium potentials in unmyelinated C fibres of biopsied human sural nerve by Quasthoff, S., Grosskreutz, J., Schröder, J.M., Schneider, U., Grafe, P.

“…Compound action potentials and electrotonic responses to 150 ms current pulses were recorded from isolated nerve fascicles of human sural nerve biopsies…”
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Activity-dependent excitability changes in normal and demyelinated rat spinal root axons by Bostock, H, Grafe, P

“…Myelinated nerve fibres with a reduced safety factor for conduction due to demyelination are easily blocked by trains of impulses. To find out why, in vivo…”
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Ion activities and potassium uptake mechanisms of glial cells in guinea-pig olfactory cortex slices by Ballanyi, K, Grafe, P, ten Bruggencate, G

“…1. Double-barrelled ion-sensitive micro-electrodes were used to measure changes in the intracellular activities of K+, Na+ and Cl- (aiK, aiNa, aiCl) in glial…”
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The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons by Grafe, P, Bostock, H, Schneider, U

“…1. Electrotonic responses to 150 ms current pulses were recorded from isolated rat dorsal roots incubated for at least 3 h with either normal (5 mM) or high…”
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Extracorporeal shock waves stimulate frog sciatic nerves indirectly via a cavitation-mediated mechanism by Schelling, G., Delius, M., Gschwender, M., Grafe, P., Gambihler, S.

“…Shock waves (SWs) are single pressure pulses with amplitudes up to over 100 MPa, a rise time of only a few nanoseconds, and a short duration of approximately 2…”
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Changes in excitability and accommodation of human motor axons following brief periods of ischaemia by Bostock, H, Baker, M, Grafe, P, Reid, G

“…1. The mechanism of post-ischaemic ectopic impulse generation in nerve is not known, and previous measurements of excitability changes in human motor axons…”
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Diadenosine pentaphosphate is more potent than ATP at P2X receptors in isolated rat vagus nerve by Burgstahler, Ralf, Grafe, Peter

“…The effects of diadenosine pentaphosphate (Ap5A), diadenosine tetraphosphate (Ap4A), α,β-methyleneATP (α,β-meATP), and ATP were studied on the excitability of…”
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Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro by Großkreutz, J., Quasthoff, S., Kühn, M., Grafe, P.

“…Topical application of capsaicin has been tested recently for treatment of painful peripheral neuropathy. In the present study, effects of capsaicin were…”
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Enhanced Proliferation and Potassium Conductance of Schwann Cells Isolated from NF2 Schwannomas Can Be Reduced by Quinidine by Rosenbaum, C., Kamleiter, M., Grafe, P., Kluwe, L., Mautner, V.-F., Müller, H.W., Hanemann, C.O.

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Enhanced Proliferation and Potassium Conductance of Schwann Cells Isolated from NF2 Schwannomas Can Be Reduced by Quinidine by Rosenbaum, C., Kamleiter, M., Grafe, P., Kluwe, L., Mautner, V.-F., Müller, H.W., Hanemann, C.O.

“…Neurofibromatosis type 2 (NF2) is an autosomal dominant disease that is characterized mainly by schwannomas, as well as menigiomas and gliomas. The NF2 gene…”
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