Search Results - "Graf, Ricarda"

Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer by Ulz, Peter, Belic, Jelena, Graf, Ricarda, Auer, Martina, Lafer, Ingrid, Fischereder, Katja, Webersinke, Gerald, Pummer, Karl, Augustin, Herbert, Pichler, Martin, Hoefler, Gerald, Bauernhofer, Thomas, Geigl, Jochen B., Heitzer, Ellen, Speicher, Michael R.

“…Genomic alterations in metastatic prostate cancer remain incompletely characterized. Here we analyse 493 prostate cancer cases from the TCGA database and…”
Get full text

Sensitive and robust liquid biopsy-based detection of PIK3CA mutations in hormone-receptor-positive metastatic breast cancer patients by Suppan, Christoph, Graf, Ricarda, Jahn, Stephan, Zhou, Qing, Klocker, Eva Valentina, Bartsch, Rupert, Terbuch, Angelika, Kashofer, Karl, Regitnig, Peter, Lindenmann, Joerg, Posch, Florian, Gerritsmann, Hanno, Jost, Philipp J., Heitzer, Ellen, Dandachi, Nadia, Balic, Marija

“…Background The benefit of alpelisib in hormone-receptor-positive (HR+) metastatic breast cancer patients provided clinical evidence for the increasing…”
Get full text

G protein‐coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1 by Hasenoehrl, Carina, Feuersinger, David, Sturm, Eva M, Bärnthaler, Thomas, Heitzer, Ellen, Graf, Ricarda, Grill, Magdalena, Pichler, Martin, Beck, Stephan, Butcher, Lee, Thomas, Dominique, Ferreirós, Nerea, Schuligoi, Rufina, Schweiger, Caroline, Haybaeck, Johannes, Schicho, Rudolf

“…The putative cannabinoid receptor GPR55 has been shown to play a tumor‐promoting role in various cancers, and is involved in many physiological and…”
Get full text

Longitudinal tumor fraction trajectories predict risk of progression in metastatic HR+ breast cancer patients undergoing CDK4/6 treatment by Dandachi, Nadia, Posch, Florian, Graf, Ricarda, Suppan, Christoph, Klocker, Eva Valentina, Müller, Hannah Deborah, Lindenmann, Jörg, Terbuch, Angelika, Heitzer, Ellen, Balic, Marija

“…With longitudinal untargeted assessment of circulating tumor DNA in metastatic HR+ breast cancer patients during CDK4/6 treatment and joint model analyses, we…”
Get full text

TP53 mutated AML subclones exhibit engraftment in a humanized bone marrow ossicle mouse model by Pabst, Gabriel, Lind, Karin, Graf, Ricarda, Zebisch, Armin, Stölzel, Friedrich, Döhner, Konstanze, Heitzer, Ellen, Reinisch, Andreas, Sill, Heinz

Get full text

Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia by Gaksch, Lukas, Kashofer, Karl, Heitzer, Ellen, Quehenberger, Franz, Daga, Shruti, Hofer, Sybille, Halbwedl, Iris, Graf, Ricarda, Krisper, Nina, Hoefler, Gerald, Zebisch, Armin, Sill, Heinz, Wölfler, Albert

“…Despite achieving complete remission after intensive therapy, most patients with cytogenetically normal (CN) AML relapse due to the persistence of…”
Get full text

Comparison of three commercial decision support platforms for matching of next-generation sequencing results with therapies in patients with cancer by Perakis, Samantha O, Weber, Sabrina, Zhou, Qing, Graf, Ricarda, Hojas, Sabine, Riedl, Jakob M, Gerger, Armin, Dandachi, Nadia, Balic, Marija, Hoefler, Gerald, Schuuring, Ed, Groen, Harry J M, Geigl, Jochen B, Heitzer, Ellen, Speicher, Michael R

“…ObjectivePrecision oncology depends on translating molecular data into therapy recommendations. However, with the growing complexity of next-generation…”
Get full text

On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer by Moser, Tina, Waldispuehl-Geigl, Julie, Belic, Jelena, Weber, Sabrina, Zhou, Qing, Hasenleithner, Samantha O., Graf, Ricarda, Terzic, Jasmin Alia, Posch, Florian, Sill, Heinz, Lax, Sigurd, Kashofer, Karl, Hoefler, Gerald, Schoellnast, Helmut, Heitzer, Ellen, Geigl, Jochen B., Bauernhofer, Thomas, Speicher, Michael R.

“…We addressed a significant unknown feature of circulating tumor DNA (ctDNA), i.e., how ctDNA levels change during chemotherapy, by serially monitoring ctDNA in…”
Get full text

Exome sequence analysis in consanguineous Pakistani families inheriting Bardet‐Biedle syndrome determined founder effect of mutation c.299delC (p.Ser100Leufs24) in BBS9 gene by Muzammal, Muhammad, Zubair, Muhammad, Bierbaumer, Sophie, Blatterer, Jasmin, Graf, Ricarda, Gul, Aisha, Abbas, Safdar, Badar, Muhammad, Abbasi, Ansar Ahmad, Khan, Muzammil Ahmad, Windpassinger, Christian

“…Background Bardet‐Biedl syndrome (BBS) is characterized by a heterogeneous phenotypic spectrum of retinopathy, intellectual disability (ID), obesity,…”
Get full text

Comparing linear discriminant analysis and supervised learning algorithms for binary classification—A method comparison study by Graf, Ricarda, Zeldovich, Marina, Friedrich, Sarah

“…In psychology, linear discriminant analysis (LDA) is the method of choice for two‐group classification tasks based on questionnaire data. In this study, we…”
Get full text

Persistence of ctDNA in Patients with Breast Cancer During Neoadjuvant Treatment Is a Significant Predictor of Poor Tumor Response by Zhou, Qing, Gampenrieder, Simon P, Frantal, Sophie, Rinnerthaler, Gabriel, Singer, Christian F, Egle, Daniel, Pfeiler, Georg, Bartsch, Rupert, Wette, Viktor, Pichler, Angelika, Petru, Edgar, Dubsky, Peter C, Bago-Horvath, Zsuzsanna, Fesl, Christian, Rudas, Margaretha, Ståhlberg, Anders, Graf, Ricarda, Weber, Sabrina, Dandachi, Nadia, Filipits, Martin, Gnant, Michael, Balic, Marija, Heitzer, Ellen

“…Accurate response assessment during neoadjuvant systemic treatment (NST) poses a clinical challenge. Therefore, a minimally invasive assessment of tumor…”
Get full text

Abstract PS4-06: Comparison of liquid biopsy and tissue based detection of PIK3CA mutations in HR positive metastatic breast cancer patients by Suppan, Christoph, Zhou, Qing, Jahn, Stephan, Graf, Ricarda, Klocker, Eva Valentina, Terbuch, Angelika, Kashofer, Karl, Posch, Florian, Gerritsmann, Hanno, Dandachi, Nadia, Heitzer, Ellen, Balic, Marija

“…Abstract The treatment of hormone receptor positive metastatic breast cancer patients has changed dramatically over the last few years and combination…”
Get full text

Genomic alterations in plasma DNA from patients with metastasized prostate cancer receiving abiraterone or enzalutamide by Belic, Jelena, Graf, Ricarda, Bauernhofer, Thomas, Cherkas, Yauheniya, Ulz, Peter, Waldispuehl‐Geigl, Julie, Perakis, Samantha, Gormley, Michael, Patel, Jaymala, Li, Weimin, Geigl, Jochen B., Smirnov, Denis, Heitzer, Ellen, Gross, Mitchell, Speicher, Michael R.

“…In patients with metastatic castrate‐resistant prostate cancer (mCRPC), circulating tumor DNA (ctDNA) analysis offers novel opportunities for the development…”
Get full text

Sensitive and broadly applicable residual disease detection in acute myeloid leukemia using flow cytometry‐based leukemic cell enrichment followed by mutational profiling by Daga, Shruti, Rosenberger, Angelika, Kashofer, Karl, Heitzer, Ellen, Quehenberger, Franz, Halbwedl, Iris, Graf, Ricarda, Krisper, Nina, Prietl, Barbara, Höfler, Gerald, Reinisch, Andreas, Zebisch, Armin, Sill, Heinz, Wölfler, Albert

“…Persistent measurable residual disease (MRD) is an increasingly important prognostic marker in acute myeloid leukemia (AML). Currently, MRD is determined by…”
Get full text

Abstract 1315: Identification of actionable targets in advanced cancer patients from circulating tumor DNA using clinical decision support platforms by Perakis, Samantha O., Weber, Sabrina, Graf, Ricarda, Zhou, Qing, Riedl, Jakob M., Dandachi, Nadia, Balic, Marija, Gerger, Armin, Schuuring, Ed, Groen, Harry J., Geigl, Jochen B., Speicher, Michael R., Heitzer, Ellen

“…Abstract BACKGROUND: We are entering exciting times in precision oncology, with next-generation sequencing enabling the individualized screening of multiple…”
Get full text

Inferring expressed genes by whole-genome sequencing of plasma DNA by Ulz, Peter, Thallinger, Gerhard G, Auer, Martina, Graf, Ricarda, Kashofer, Karl, Jahn, Stephan W, Abete, Luca, Pristauz, Gunda, Petru, Edgar, Geigl, Jochen B, Heitzer, Ellen, Speicher, Michael R

“…Michael Speicher and colleagues analyze plasma DNA whole-genome sequencing data from healthy donors and patients with cancer to infer nucleosome positioning on…”
Get full text

369 Differential Roles of G Protein-Coupled Receptors GPR55 and CB1 in Colon Cancer by Hasenoehrl, Carina, Feuersinger, David, Graf, Ricarda, Heitzer, Ellen, Haybaeck, Johannes, Schuligoi, Rufina, Schicho, Rudolf

Get full text

Abstract P5-02-46: Targeted capture sequencing allows sensitive genomic profiling of circulating tumor DNA in advanced HR+/HER- breast cancer patients by Dandachi, Nadia, Graf, Ricarda, Potocnik, Nina, Pancheri, Lara, Klocker, Eva, Suppan, Christoph, Jost, Philipp, Gerritsmann, Hanno, Heitzer, Ellen, Balic, Marija

“…Abstract Introduction: CDK4/6 inhibitors provide substantial benefits as 1st or 2nd line treatments and are now the standard of care for patients with advanced…”
Get full text

Dynamic Changes of Circulating Tumor DNA Predict Clinical Outcome in Patients With Advanced Non-Small-Cell Lung Cancer Treated With Immune Checkpoint Inhibitors by Weber, Sabrina, van der Leest, Paul, Donker, Hylke C, Schlange, Thomas, Timens, Wim, Tamminga, Menno, Hasenleithner, Samantha O, Graf, Ricarda, Moser, Tina, Spiegl, Benjamin, Yaspo, Marie-Laure, Terstappen, Leon W M M, Sidorenkov, Grigory, Hiltermann, T Jeroen N, Speicher, Michael R, Schuuring, Ed, Heitzer, Ellen, Groen, Harry J M

“…Immune checkpoint inhibitors (ICIs) are increasingly being used in non-small-cell lung cancer (NSCLC), yet biomarkers predicting their benefit are lacking. We…”
Get more information

Detection of AML-specific TP53 mutations in bone marrow–derived mesenchymal stromal cells cultured under hypoxia conditions by Müller, Marian, Graf, Ricarda, Kashofer, Karl, Macher, Susanne, Wölfler, Albert, Zebisch, Armin, Hrzenjak, Andelko, Heitzer, Ellen, Sill, Heinz

Get full text