Search Results - "Graf, Gregory A"

Age and sex are associated with the plasma lipidome: findings from the GOLDN study by Slade, Emily, Irvin, Marguerite R, Xie, Kevin, Arnett, Donna K, Claas, Steven A, Kind, Tobias, Fardo, David W, Graf, Gregory A

“…Developing an understanding of the biochemistry of aging in both sexes is critical for managing disease throughout the lifespan. Lipidomic associations with…”
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Sitosterolemia: Twenty Years of Discovery of the Function of ABCG5ABCG8 by Williams, Kori, Segard, Allison, Graf, Gregory A.

“…Sitosterolemia is a lipid disorder characterized by the accumulation of dietary xenosterols in plasma and tissues caused by mutations in either ABCG5 or ABCG8…”
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The prorenin receptor and its soluble form contribute to lipid homeostasis by Gatineau, Eva, Arthur, Gertrude, Poupeau, Audrey, Nichols, Kellea, Spear, Brett T, Shelman, Nathan R, Graf, Gregory A, Temel, Ryan E, Yiannikouris, Frédérique B

“…Obesity is associated with alterations in hepatic lipid metabolism. We previously identified the prorenin receptor (PRR) as a potential contributor to liver…”
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Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice by Salous, Abdel K., Panchatcharam, Manikandan, Sunkara, Manjula, Mueller, Paul, Dong, Anping, Wang, Yuhuan, Graf, Gregory A., Smyth, Susan S., Morris, Andrew J.

“…Lysophosphatidic acid (LPA) is a bioactive lipid mediator. Concentrations of the major LPA species in mouse plasma decreased uniformly following administration…”
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The ABCG5 ABCG8 Sterol Transporter Opposes the Development of Fatty Liver Disease and Loss of Glycemic Control Independently of Phytosterol Accumulation by Su, Kai, Sabeva, Nadezhda S., Liu, Jingjing, Wang, Yuhuan, Bhatnagar, Saloni, van der Westhuyzen, Deneys R., Graf, Gregory A.

“…ABCG5 and ABCG8 form a complex (G5G8) that opposes the absorption of plant sterols but is also expressed in liver where it promotes the excretion of…”
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ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion by Graf, Gregory A, Yu, Liqing, Li, Wei-Ping, Gerard, Robert, Tuma, Pamela L, Cohen, Jonathan C, Hobbs, Helen H

“…ABCG5 (G5) and ABCG8 (G8) are ATP-binding cassette (ABC) transporters that limit intestinal absorption and promote biliary excretion of neutral sterols…”
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Bioinformatic analysis of endogenous and exogenous small RNAs on lipoproteins by Allen, Ryan M., Zhao, Shilin, Ramirez Solano, Marisol A., Zhu, Wanying, Michell, Danielle L., Wang, Yuhuan, Shyr, Yu, Sethupathy, Praveen, Linton, MacRae F., Graf, Gregory A., Sheng, Quanhu, Vickers, Kasey C.

“…To comprehensively study extracellular small RNAs (sRNA) by sequencing (sRNA-seq), we developed a novel pipeline to overcome current limitations in analysis…”
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Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters by Berge, Knut E., Tian, Hui, Graf, Gregory A., Yu, Liqing, Grishin, Nick V., Schultz, Joshua, Kwiterovich, Peter, Shan, Bei, Barnes, Robert, Hobbs, Helen H.

“…In healthy individuals, acute changes in cholesterol intake produce modest changes in plasma cholesterol levels. A striking exception occurs in sitosterolemia,…”
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Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice by Zelows, Mikala M., Cady, Corissa, Dharanipragada, Nikitha, Mead, Anna E., Kipp, Zachary A., Bates, Evelyn A., Varadharajan, Venkateshwari, Banerjee, Rakhee, Park, Se-Hyung, Shelman, Nathan R., Clarke, Harrison A., Hawkinson, Tara R., Medina, Terrymar, Sun, Ramon C., Lydic, Todd A., Hinds, Terry D., Brown, J. Mark, Softic, Samir, Graf, Gregory A., Helsley, Robert N.

“…Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of…”
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The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination[S] by Wang, Yuhuan, Liu, Xiaoxi, Pijut, Sonja S., Li, Jianing, Horn, Jamie, Bradford, Emily M., Leggas, Markos, Barrett, Terrence A., Graf, Gregory A.

“…Previous studies suggest an interdependent relationship between liver and intestine for cholesterol elimination from the body. We hypothesized that a…”
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Sitosterolemia: Twenty Years of Discovery of the Function of ABCG5 ABCG8 by Williams, Kori, Segard, Allison, Graf, Gregory A

“…Sitosterolemia is a lipid disorder characterized by the accumulation of dietary xenosterols in plasma and tissues caused by mutations in either or . encodes a…”
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Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster by Burke, Katie T., Colvin, Perry L., Myatt, Leslie, Graf, Gregory A., Schroeder, Friedhelm, Woollett, Laura A.

“…The fetus has a high requirement for cholesterol and synthesizes cholesterol at elevated rates. Recent studies suggest that fetal cholesterol also can be…”
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ABCG5 and ABCG8: more than a defense against xenosterols by Patel, Shailendra B, Graf, Gregory A, Temel, Ryan E

“…The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized our mechanistic understanding of how dietary sterols are…”
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ABCD2 is abundant in adipose tissue and opposes the accumulation of dietary erucic acid (C22:1) in fat[S] by Liu, Jingjing, Sabeva, Nadezhda S., Bhatnagar, Saloni, Li, Xiang-An, Pujol, Aurora, Graf, Gregory A.

“…The ATP binding cassette transporter, ABCD2 (D2), is a peroxisomal protein whose mRNA has been detected in the adrenal, brain, liver, and fat. Although the…”
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The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid[S] by Liu, Jingjing, Liang, Shuang, Liu, Xiaoxi, Brown, J.Andrew, Newman, Kylie E., Sunkara, Manjula, Morris, Andrew J., Bhatnagar, Saloni, Li, Xiangan, Pujol, Aurora, Graf, Gregory A.

“…ABCD2 (D2) is a peroxisomal transporter that is highly abundant in adipose tissue and promotes the oxidation of long-chain MUFA. Erucic acid (EA, 22:1ω9)…”
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Defects in the Leptin Axis Reduce Abundance of the ABCG5-ABCG8 Sterol Transporter in Liver by Sabeva, Nadezhda S., Rouse, Eric J., Graf, Gregory A.

“…ABGG5 (G5) and ABCG8 (G8) are ABC half-transporters that dimerize within the endoplasmic reticulum, traffic to the cell surface, and mediate cholesterol…”
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Metabolomics, Lipid Pathways, and Blood Pressure Change by Arnett, Donna K., Graf, Gregory A.

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Missense Mutations in ABCG5 and ABCG8 Disrupt Heterodimerization and Trafficking by Graf, Gregory A, Cohen, Jonathan C, Hobbs, Helen H

“…Mutations in ABCG5 (G5) or ABCG8 (G8) cause sitosterolemia, an autosomal recessive disease characterized by sterol accumulation and premature atherosclerosis…”
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ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion by Zein, Aiman A, Kaur, Rupinder, Hussein, Toka O K, Graf, Gregory A, Lee, Jyh-Yeuan

“…The ABCG5/G8 heterodimer is the primary neutral sterol transporter in hepatobiliary and transintestinal cholesterol excretion. Inactivating mutations on either…”
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Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine by Lifsey, Hannah C., Kaur, Rupinder, Thompson, Bradley H, Bennett, Lisa, Temel, Ryan E., Graf, Gregory A.

“…Despite advances in healthcare, cardiovascular disease (CVD) remains the leading cause of death in the United States. Elevated levels of plasma cholesterol are…”
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