Search Results - "Graeber, Martin"

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel by Liu, Fa, Park, Jung-Eun, Qian, Wen-Jian, Lim, Dan, Gräber, Martin, Berg, Thorsten, Yaffe, Michael B, Lee, Kyung S, Burke, Terrence R

“…Polo-like kinase 1 (Plk1) regulates multiple processes that are important for cell proliferation, and it is a promising anticancer drug target. Efforts to…”
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The STAT5b Linker Domain Mediates the Selectivity of Catechol Bisphosphates for STAT5b over STAT5a by Gräb, Julian, Berg, Angela, Blechschmidt, Linda, Klüver, Barbara, Rubner, Stefan, Fu, Darwin Y, Meiler, Jens, Gräber, Martin, Berg, Thorsten

“…STAT family proteins are important mediators of cell signaling and represent therapeutic targets for the treatment of human diseases. Most STAT inhibitors…”
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Direct monitoring of protein–protein inhibition using nano electrospray ionization mass spectrometry by Cubrilovic, Dragana, Barylyuk, Konstantin, Hofmann, Daniela, Walczak, Michal Jerzy, Gräber, Martin, Berg, Thorsten, Wider, Gerhard, Zenobi, Renato

“…Dissociation of the TNF-alpha trimer caused by the small-molecule inhibitor SPD304 was monitored using native ESI-MS and ion mobility spectrometry (IMS). Upon…”
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A High-Throughput Fluorescence Polarization-Based Assay for the SH2 Domain of STAT4 by Berg, Angela, Gräber, Martin, Schmutzler, Sebastian, Hoffmann, Ralf, Berg, Thorsten

“…The signal transducer and activation of transcription (STAT) proteins are a family of Src homology 2 (SH2) domain-containing transcription factors. The family…”
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Development of high-throughput assays based on fluorescence polarization for inhibitors of the polo-box domains of polo-like kinases 2 and 3 by Reindl, Wolfgang, Gräber, Martin, Strebhardt, Klaus, Berg, Thorsten

“…The serine/threonine kinases Plk1, Plk2, and Plk3 harbor a protein–protein interaction domain dubbed polo-box domain (PBD). Recently, the inhibition of the PBD…”
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Oral Disinfectants Inhibit Protein-Protein Interactions Mediated by the Anti-Apoptotic Protein Bcl-x sub(L) and Induce Apoptosis in Human Oral Tumor Cells by Graeber, Martin, Hell, Michael, Grost, Corinna, Friberg, Anders, Sperl, Bianca, Sattler, Michael, Berg, Thorsten

“…Chlorhexidine and alexidine have long been used as oral disinfectants by humans. Both compounds inhibit protein-protein interactions mediated by the…”
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Synthesis and biochemical evaluation of highly enantiomerically pure (R,R)- and (S,S)-alexidine by Gröst, Corinna, Gräber, Martin, Hell, Michael, Berg, Thorsten

“…Alexidine is in everyday human use as oral disinfectant and contact lens disinfectant. It is used as a mixture of stereoisomers. Since all of alexidine’s known…”
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Selective Targeting of Disease-Relevant Protein Binding Domains by O-Phosphorylated Natural Product Derivatives by Gräber, Martin, Janczyk, Weronika, Sperl, Bianca, Elumalai, Nagarajan, Kozany, Christian, Hausch, Felix, Holak, Tad A, Berg, Thorsten

“…Phosphorylation-dependent protein binding domains are crucially important for intracellular signaling pathways and thus highly relevant targets in chemical…”
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The Natural Product Betulinic Acid Inhibits C/EBP Family Transcription Factors by Hollis, Angela, Sperl, Bianca, Gräber, Martin, Berg, Thorsten

“…Nature does it: Small‐molecule inhibitors of transcription factors are highly sought after, but only a limited number are known to date. Here, we report the…”
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Phosphopeptides with improved cellular uptake properties as ligands for the polo-box domain of polo-like kinase 1 by Richter, Susan, Neundorf, Ines, Loebner, Kristin, Gräber, Martin, Berg, Thorsten, Bergmann, Ralf, Steinbach, Joerg, Pietzsch, Jens, Wuest, Frank

“…Human polo-like kinase 1 (Plk1) is involved in cell proliferation and overexpressed in a broad variety of different cancer types. Due to its crucial role in…”
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Orale Desinfektionsmittel inhibieren Protein‐Protein‐Wechselwirkungen des antiapoptotischen Proteins Bcl‐x L und induzieren Apoptose in humanen oralen Tumorzellen by Gräber, Martin, Hell, Michael, Gröst, Corinna, Friberg, Anders, Sperl, Bianca, Sattler, Michael, Berg, Thorsten

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Orale Desinfektionsmittel inhibieren Protein-Protein-Wechselwirkungen des antiapoptotischen Proteins Bcl-xL und induzieren Apoptose in humanen oralen Tumorzellen by Gräber, Martin, Hell, Michael, Gröst, Corinna, Friberg, Anders, Sperl, Bianca, Sattler, Michael, Berg, Thorsten

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