Search Results - "Graeb, Jessica"

Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19 by Theobald, Sebastian J, Simonis, Alexander, Georgomanolis, Theodoros, Kreer, Christoph, Zehner, Matthias, Eisfeld, Hannah S, Albert, Marie‐Christine, Chhen, Jason, Motameny, Susanne, Erger, Florian, Fischer, Julia, Malin, Jakob J, Gräb, Jessica, Winter, Sandra, Pouikli, Andromachi, David, Friederike, Böll, Boris, Koehler, Philipp, Vanshylla, Kanika, Gruell, Henning, Suárez, Isabelle, Hallek, Michael, Fätkenheuer, Gerd, Jung, Norma, Cornely, Oliver A, Lehmann, Clara, Tessarz, Peter, Altmüller, Janine, Nürnberg, Peter, Kashkar, Hamid, Klein, Florian, Koch, Manuel, Rybniker, Jan

“…Innate immunity triggers responsible for viral control or hyperinflammation in COVID‐19 are largely unknown. Here we show that the SARS‐CoV‐2 spike protein…”
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Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition by Gräb, Jessica, Suárez, Isabelle, van Gumpel, Edeltraud, Winter, Sandra, Schreiber, Fynn, Esser, Anna, Hölscher, Christoph, Fritsch, Melanie, Herb, Marc, Schramm, Michael, Wachsmuth, Laurens, Pallasch, Christian, Pasparakis, Manolis, Kashkar, Hamid, Rybniker, Jan

“…Corticosteroids are host-directed drugs with proven beneficial effect on survival of tuberculosis (TB) patients, but their precise mechanisms of action in this…”
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Chemical p38 MAP kinase inhibition constrains tissue inflammation and improves antibiotic activity in Mycobacterium tuberculosis-infected mice by Hölscher, Christoph, Gräb, Jessica, Hölscher, Alexandra, Müller, Annie Linnea, Schäfer, Stephan C., Rybniker, Jan

“…Host-modulating therapies have become an important focus in the development of novel concepts for improved management of tuberculosis (TB). Previous in vitro…”
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Repurposing QuantiFERON for Detection of Neutralizing Interferon-γ Autoantibodies in Patients With Nontuberculous Mycobacterial Infections by Suárez, Isabelle, Lehmann, Clara, Gruell, Henning, Graeb, Jessica, Kochanek, Matthias, Fätkenheuer, Gerd, Plum, Georg, van Wengen, Annelies, van de Vosse, Esther, Hartmann, Pia, Hanitsch, Leif G., Rybniker, Jan

“…Nontuberculous mycobacterial infections due to autoantibodies targeting interferon-γ are an emerging medical problem. However, case finding is hampered due to…”
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Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages by Theobald, Sebastian J., Gräb, Jessica, Fritsch, Melanie, Suárez, Isabelle, Eisfeld, Hannah S., Winter, Sandra, Koch, Maximilian, Hölscher, Christoph, Pasparakis, Manolis, Kashkar, Hamid, Rybniker, Jan

“…Necrotic cell death represents a major pathogenic mechanism of Mycobacterium tuberculosis ( Mtb ) infection. It is increasingly evident that Mtb induces…”
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