Search Results - "Gradilone, A"

The primary cilium: Its role as a tumor suppressor organelle by Peixoto, Estanislao, Richard, Seth, Pant, Kishor, Biswas, Aalekhya, Gradilone, Sergio A.

“…[Display omitted] The primary cilium is an organelle that nearly all cells within the body contain. Its function is to sense the extracellular environment…”
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The cholangiocyte primary cilium in health and disease by Mansini, Adrian P., Peixoto, Estanislao, Thelen, Kristen M., Gaspari, Cesar, Jin, Sujeong, Gradilone, Sergio A.

“…Cholangiocytes, like most cells, express primary cilia extending from their membranes. These organelles function as antennae which detect stimuli from bile and…”
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HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth by GRADILONE, Sergio A, RADTKE, Brynn N, BOGERT, Pamela S, HUANG, Bing Q, GAJDOS, Gabriella B, LARUSSO, Nicholas F

“…Primary cilia are multisensory organelles recently found to be absent in some tumor cells, but the mechanisms of deciliation and the role of cilia in tumor…”
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Hepatobiliary Cancers: Progress in Diagnosis, Pathogenesis, and Treatment by Pant, Kishor, Gradilone, Sergio A.

“…Hepatobiliary cancers comprise a wide range of malignancies such as hepatocellular carcinoma and cholangiocarcinoma, and they are some of the most challenging…”
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The Chemosensory Function of Primary Cilia Regulates Cholangiocyte Migration, Invasion, and Tumor Growth by Mansini, Adrian P., Peixoto, Estanislao, Jin, Sujeong, Richard, Seth, Gradilone, Sergio A.

“…Cholangiocytes, the epithelial cells lining the biliary tree in the liver, express primary cilia that can detect several kinds of environmental signals and…”
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Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma by Pant, Kishor, Peixoto, Estanislao, Richard, Seth, Gradilone, Sergio A

“…Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and…”
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Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling by Masyuk, Anatoliy I, Huang, Bing Q, Radtke, Brynn N, Gajdos, Gabriella B, Splinter, Patrick L, Masyuk, Tatyana V, Gradilone, Sergio A, LaRusso, Nicholas F

“…TGR5, the G protein-coupled bile acid receptor that transmits bile acid signaling into a cell functional response via the intracellular cAMP signaling pathway,…”
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Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma by Gradilone, Sergio A, Pisarello, Maria J Lorenzo, LaRusso, Nicholas F

“…Cilia are microtubule-based organelles, which are ubiquitously expressed in epithelial cells. Cholangiocytes, the epithelial cells lining the biliary tree,…”
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Short-Chain Fatty Acid Butyrate Induces Cilia Formation and Potentiates the Effects of HDAC6 Inhibitors in Cholangiocarcinoma Cells by Pant, Kishor, Richard, Seth, Gradilone, Sergio A

“…Cholangiocarcinoma (CCA) is a deadly form of liver cancer with limited therapeutic approaches. The pathogenesis of CCA involves the loss of primary cilia in…”
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Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease by Lorenzo Pisarello, Maria, Masyuk, Tatyana V., Gradilone, Sergio A., Masyuk, Anatoliy I., Ding, Jingyi F., Lee, Pui-Yuen, LaRusso, Nicholas F.

“…Hepatic cystogenesis in polycystic liver disease (PLD) is associated with abnormalities in multiple cellular processes, including elevated cAMP and…”
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Prognostic value of circulating tumor cells in nonmuscle invasive bladder cancer: a CellSearch analysis by Gazzaniga, P., Gradilone, A., de Berardinis, E., Busetto, G.M., Raimondi, C., Gandini, O., Nicolazzo, C., Petracca, A., Vincenzi, B., Farcomeni, A., Gentile, V., Cortesi, E., Frati, L.

“…Circulating tumor cells (CTCs) provide prognostic information in patients with metastatic tumors. Recent studies have shown that CTCs are released in…”
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Circulating tumor cells (CTCs) in metastatic breast cancer (MBC): prognosis, drug resistance and phenotypic characterization by Gradilone, A., Naso, G., Raimondi, C., Cortesi, E., Gandini, O., Vincenzi, B., Saltarelli, R., Chiapparino, E., Spremberg, F., Cristofanilli, M., Frati, L., Aglianò, A.M., Gazzaniga, P.

“…Background: The expression of ATP-binding cassette transporters on circulating tumor cells (CTCs) is predictive of response to chemotherapy in cancer patients…”
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Role of Glucose Metabolism Reprogramming in the Pathogenesis of Cholangiocarcinoma by Pant, Kishor, Richard, Seth, Peixoto, Estanislao, Gradilone, Sergio A

“…Cholangiocarcinoma (CCA) is one of the most lethal cancers, and its rate of occurrence is increasing annually. The diagnoses of CCA patients remain elusive due…”
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Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion by Gradilone, Sergio A, Masyuk, Anatoliy I, Splinter, Patrick L, Banales, Jesus M, Huang, Bing Q, Tietz, Pamela S, Masyuk, Tatyana V, LaRusso, Nicholas F

“…Cholangiocytes, epithelial cells lining the biliary tree, have primary cilia extending from their apical membrane into the ductal lumen. Although important in…”
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HDAC6 Is Overexpressed in Cystic Cholangiocytes and Its Inhibition Reduces Cystogenesis by Gradilone, Sergio A, Habringer, Stefan, Masyuk, Tatyana V, Howard, Brynn N, Masyuk, Anatoliy I, LaRusso, Nicholas F

“…Polycystic liver disease (PLD) is a member of the cholangiopathies, a group of liver diseases in which cholangiocytes, the epithelia lining of the biliary…”
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Detecting the disappearance of RAS-mutant clones in the plasma of patients with RAS-mutant mCRC to select patient candidates for anti-EGFR treatment and to monitor resistance to treatment by Raimondi, C., Loreni, F., Nicolazzo, C., Belardinilli, F., Wilson, A., Gradilone, A., Giannini, G., Gazzaniga, P., Cortesi, E.

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The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD) by Banales, Jesús M., Masyuk, Tatyana V., Gradilone, Sergio A., Masyuk, Anatoliy I., Medina, Juan F., LaRusso, Nicholas F.

“…PCK rats, an animal model of autosomal recessive polycystic kidney disease (ARPKD), develop cholangiocyte‐derived liver cysts associated with increased…”
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Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics by Ji, Bai, Harris, Benjamin R E, Liu, Yahui, Deng, Yibin, Gradilone, Sergio A, Cleary, Margot P, Liu, Jianhua, Yang, Da-Qing

“…While translational regulation of p53 by the internal ribosome entry site (IRES) at its 5'-untranslated region following DNA damage has been widely accepted,…”
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The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth by Pant, Kishor, Richard, Seth, Peixoto, Estanislao, Yin, Jun, Seelig, Davis M, Carotenuto, Pietro, Salati, Massimiliano, Franco, Brunella, Roberts, Lewis R, Gradilone, Sergio A

“…It is well established that Cholangiocarcioma (CCA) drug resistance plays a crucial role in the spread and survival of cancer cells. The major enzyme in the…”
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Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD by Gradilone, Sergio A, Masyuk, Tatyana V, Huang, Bing Q, Banales, Jesus M, Lehmann, Guillermo L, Radtke, Brynn N, Stroope, Angela, Masyuk, Anatoliy I, Splinter, Patrick L, LaRusso, Nicholas F

“…Background & Aims In polycystic liver diseases, cyst formation involves cholangiocyte hyperproliferation. In polycystic kidney (PCK) rats, an animal model of…”
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