Search Results - "Graczyk, Piotr P."

Gini Coefficient:  A New Way To Express Selectivity of Kinase Inhibitors against a Family of Kinases by Graczyk, Piotr P

“…A novel application of the Gini coefficient for expressing selectivity of kinase inhibitors against a panel of kinases is proposed. This has been illustrated…”
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Lesinurad – There are More Ways than One of Synthesizing the Drug by Nerdinger, Sven, P. Graczyk, Piotr

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JNK inhibitors as anti-inflammatory and neuroprotective agents by Graczyk, Piotr P

“…JNK is involved in a broad range of physiological processes. Several inflammatory and neurodegenerative diseases, such as multiple sclerosis, Alzheimer's and…”
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Mini-Review: The Chemistry of Vorapaxar – Is There Any Room for Improvement Left? by P. Graczyk, Piotr, Nerdinger, Sven

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A short synthesis of Dronedarone by Piotrkowska, Barbara, Nerdinger, Sven, Schreiner, Erwin, Selič, Lovro, Graczyk, Piotr P.

“…[Display omitted] A modification of the Nenitzescu reaction was used to obtain Dronedarone from quinonimine 20 and 1,3-diketone 14 (R = CH2CH2CH2NBu2) in a…”
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The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold by GRACZYK, Piotr P, KHAN, Afzal, SMALES, Caroline, WHITFIELD, Jonathan, NEAME, Stephen J, SHAH, Bina, WILTON, Daniel, MORGAN, Louise, PATEL, Toshal, CHUNG, Raymond, DESMOND, Howard, STADDON, James M, BHATIA, Gurpreet S, SATO, Nobuaki, INOUE, Atsushi, PALMER, Vanessa, MEDLAND, Darren, NUMATA, Hirotoshi, OINUMA, Hitoshi, CATCHICK, Jacqueline, DUNNE, Angela, ELLIS, Moira

“…Imidazole-based structures of p38 inhibitors served as a starting point for the design of JNK3 inhibitors. Construction of a…”
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Conformational Preference in 1,3-Dithianes Containing 2-Phosphoryl, -(thiophosphoryl), and -(selenophosphoryl) groups. Chemical and Crystallographic Implications of the Nature of the Anomeric Effect by Mikolajczyk, Marian, Graczyk, Piotr P, Wieczorek, Michal W

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Synthesis and Conformational Behavior of 2-Phosphonio- and 2-Phosphinyl-1,3-dithianes. Operation of the Generalized Anomeric Effect in the S-C-P+ System by Mikolajczyk, Marian, Graczyk, Piotr P

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Evolution of synthetic routes towards homochiral Tapentadol by Graczyk, Piotr P., Zbrojkiewicz, Olga, Nerdinger, Sven

“…[Display omitted] Analysis of the literature shows that the development of synthetic approaches to Tapentadol, an agonist of the μ-opioid receptor and…”
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Inapplicability of the Antiperiplanar Lone Pair Hypothesis to C−P Bond Breaking and Formation in Some S−C−P+ Systems by Graczyk, Piotr P, Mikolajczyk, Marian

“…Both C(2)−P bond breaking and formation in the S−C−P+ system do not occur according to the antiperiplanar lone pair hypothesis. Experiments using 2-phosphonio…”
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A mild protocol for the deoxygenation of α-hydrogen-containing sulfoxides to the corresponding sulfides by Bhatia, Gurpreet S., Graczyk, Piotr P.

“…Graphic A mild method for the deoxygenation of α-hydrogen-containing sulfoxides to sulfides is reported. This synthetically useful and operationally simple…”
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Caspase inhibitors as anti-inflammatory and antiapoptotic agents by Graczyk, Piotr P

“…The striking efficacy of Z-VAD-fmk in the various animal models presented above may reflect its ability to inhibit multiple enzymes including caspases. In…”
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The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5 H-pyrrolo[1,2- a]imidazole scaffold by Graczyk, Piotr P., Khan, Afzal, Bhatia, Gurpreet S., Palmer, Vanessa, Medland, Darren, Numata, Hirotoshi, Oinuma, Hitoshi, Catchick, Jacqueline, Dunne, Angela, Ellis, Moira, Smales, Caroline, Whitfield, Jonathan, Neame, Stephen J., Shah, Bina, Wilton, Daniel, Morgan, Louise, Patel, Toshal, Chung, Raymond, Desmond, Howard, Staddon, James M., Sato, Nobuaki, Inoue, Atsushi

“…The synthesis and neuroprotective properties of three representative enantiomeric pairs ( S)- 2 and ( R)- 2 are reported. Imidazole-based structures of p38…”
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Solid state conformation of the anomeric effect in 2-phosphoryl-, 2-thiophosphoryl- and 2-selenophosphoryl-substituted 1,3-dithiolanes by Mikołajczyk, Marian, Łuczak, Tomasz, Graczyk, Piotr P., Wieczorek, Michał W., Błaszczyk, Jarosław, Bujacz, Grzegorz D., Majzner, Wiesław R.

“…The crystal structure of the title compounds 1ȁ3 have been determined by X-ray diffraction studies. The 1,3-dithiolane ring in all three compounds adopts a…”
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2-(Diphenylphosphinoyl)-1,3-dioxane by Majzner, W. R., Wieczorek, M. W., Mikołajczyk, M., Graczyk, P. P.

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