Search Results - "Grabowski, G."

Innovation in the pharmaceutical industry: New estimates of R&D costs by DiMasi, Joseph A., Grabowski, Henry G., Hansen, Ronald W.

“…•R&D costs of 106 new drugs were obtained from a survey of 10 biopharmaceutical firms.•Costs for compounds that were abandoned were linked to costs of approved…”
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Economics of New Oncology Drug Development by DiMasi, Joseph A, Grabowski, Henry G

“…Review existing studies and provide new results on the development, regulatory, and market aspects of new oncology drug development. We utilized data from the…”
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Pokémon GO-A New Distraction for Drivers and Pedestrians by Ayers, John W, Leas, Eric C, Dredze, Mark, Allem, Jon-Patrick, Grabowski, Jurek G, Hill, Linda

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The cost of biopharmaceutical R&D: is biotech different? by DiMasi, Joseph A., Grabowski, Henry G.

“…The costs of developing the types of new drugs that have been pursued by traditional pharmaceutical firms have been estimated in a number of studies. However,…”
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The price of innovation: new estimates of drug development costs by DiMasi, Joseph A, Hansen, Ronald W, Grabowski, Henry G

“…The research and development costs of 68 randomly selected new drugs were obtained from a survey of 10 pharmaceutical firms. These data were used to estimate…”
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Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models by Xu, Y.H., Sun, Y., Ran, H., Quinn, B., Witte, D., Grabowski, G.A.

“…Gaucher disease, a prevalent lysosomal storage disease, is caused by insufficient activity of acid β-glucosidase (GCase) and resultant glucosylceramide…”
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The effect of enzyme replacement therapy on bone crisis and bone pain in patients with type 1 Gaucher disease by Charrow, J, Dulisse, B, Grabowski, GA, Weinreb, NJ

“…The effect of enzyme replacement therapy (ERT) on bone crisis and bone pain was investigated in patients with Gaucher disease (GD) type 1 followed over 4…”
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Economic Return of Clinical Trials Performed Under the Pediatric Exclusivity Program by Li, Jennifer S, Eisenstein, Eric L, Grabowski, Henry G, Reid, Elizabeth D, Mangum, Barry, Schulman, Kevin A, Goldsmith, John V, Murphy, M. Dianne, Califf, Robert M, Benjamin, Daniel K

“…CONTEXT In 1997, Congress authorized the US Food and Drug Administration (FDA) to grant 6-month extensions of marketing rights through the Pediatric…”
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Management of non-neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use of biomarkers and bone disease monitoring by Cox, T. M., Aerts, J. M. F. G., Belmatoug, N., Cappellini, M. D., vom Dahl, S., Goldblatt, J., Grabowski, G. A., Hollak, C. E. M., Hwu, P., Maas, M., Martins, A. M., Mistry, P. K., Pastores, G. M., Tylki-Szymanska, A., Yee, J., Weinreb, N.

“…Summary Enzyme replacement was introduced as treatment for non-neuronopathic Gaucher disease more than 15 years ago. To ensure the best use of this costly…”
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Generic competition and market exclusivity periods in pharmaceuticals by Grabowski, Henry G., Kyle, Margaret

“…In this paper we examine generic competition and market exclusivity periods for pharmaceuticals experiencing their initial generic entry between 1995 and 2005…”
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Evolving brand-name and generic drug competition may warrant a revision of the Hatch-Waxman Act by Grabowski, Henry G, Kyle, Margaret, Mortimer, Richard, Long, Genia, Kirson, Noam

“…The evolution of pharmaceutical competition since Congress passed the Hatch-Waxman Act in 1984 raises questions about whether the act's intended balance of…”
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Determination of Parameters of the Moulding Sand Reclamation Process, on the Thermal Analysis Bases by Łucarz, M., Grabowska, B., Grabowski, G.

“…For the practical and functional reasons the investigation of the thermal decomposition process is of an essential meaning in relation to the thermal…”
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Graduated Driver Licensing Research, 2010-Present by Williams, Allan F., Tefft, Brian C., Grabowski, Jurek G.

“…This is the latest in a series of reviews of research on graduated driver licensing (GDL) published in the Journal of Safety Research, covering the period…”
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Ceramic matrix composites in the alumina/5–30 vol.% YAG system by Lach, R., Haberko, K., Bućko, M.M., Szumera, M., Grabowski, G.

“…The preparation technique of the particulate composite materials in the alumina/YAG system was elaborated. Within alumina particles suspension yttria precursor…”
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Ceramic matrix composites in the alumina/5–30vol.% YAG system by Lach, R., Haberko, K., Bućko, M.M., Szumera, M., Grabowski, G.

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Genotype-phenotype correlations in Rubinstein-Taybi syndrome by Schorry, E.K., Keddache, M., Lanphear, N., Rubinstein, J.H., Srodulski, S., Fletcher, D., Blough-Pfau, R.I., Grabowski, G.A.

“…Rubinstein–Taybi syndrome (RTS) is a rare multiple congenital anomaly/intellectual impairment syndrome. Loss of function in CREBBP or EP300 genes has been…”
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EMS Helicopter Crashes: What Influences Fatal Outcome? by Baker, Susan P., Grabowski, Jurek G., Dodd, Robert S., Shanahan, Dennis F., Lamb, Margaret W., Li, Guohua H.

“…In recent years, air transport of patients has been associated with disproportionate increases in crashes and deaths. We identify factors related to fatal…”
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Gaucher disease: Perspectives on a prototype lysosomal disease by Zhao, H, Grabowski, G A

“…Gaucher disease is an autosomal recessive trait and the most common lysosomal storage disease. The pathogenesis evolves from the diminished activity of the…”
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Developing Drugs For Developing Countries by Ridley, David B, Grabowski, Henry G, Moe, Jeffrey L

“…Infectious and parasitic diseases create enormous health burdens, but because most of the people suffering from these diseases are poor, little is invested in…”
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Using lean-based systems engineering to increase capacity in the emergency department by White, Benjamin A, Chang, Yuchiao, Grabowski, Beth G, Brown, David F M

“…While emergency department (ED) crowding has myriad causes and negative downstream effects, applying systems engineering science and targeting throughput…”
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