Search Results - "Grabovska, Yura"

Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity by Grabovska, Yura, Mackay, Alan, O’Hare, Patricia, Crosier, Stephen, Finetti, Martina, Schwalbe, Edward C., Pickles, Jessica C., Fairchild, Amy R., Avery, Aimee, Cockle, Julia, Hill, Rebecca, Lindsey, Janet, Hicks, Debbie, Kristiansen, Mark, Chalker, Jane, Anderson, John, Hargrave, Darren, Jacques, Thomas S., Straathof, Karin, Bailey, Simon, Jones, Chris, Clifford, Steven C., Williamson, Daniel

“…Immune-therapy is an attractive alternative therapeutic approach for targeting central nervous system (CNS) tumors and the constituency of the Tumor Immune…”
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Molecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas by Wong, Queenie Hoi-Wing, Li, Kay Ka-Wai, Wang, Wei-Wei, Malta, Tathiane M., Noushmehr, Houtan, Grabovska, Yura, Jones, Chris, Chan, Aden Ka-Yin, Kwan, Johnny Sheung-Him, Huang, Queenie Jun-Qi, Wong, Gabriel Chun-Hei, Li, Wen-Cai, Liu, Xian-Zhi, Chen, Hong, Chan, Danny Tat-Ming, Mao, Ying, Zhang, Zhen-Yu, Shi, Zhi-Feng, Ng, Ho-Keung

“…WHO 2016 classified glioblastomas into IDH-mutant and IDH-wildtype with the former having a better prognosis but there was no study on IDH-mutant primary…”
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RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML by Loke, Justin, Assi, Salam A., Imperato, Maria Rosaria, Ptasinska, Anetta, Cauchy, Pierre, Grabovska, Yura, Soria, Natalia Martinez, Raghavan, Manoj, Delwel, H. Ruud, Cockerill, Peter N., Heidenreich, Olaf, Bonifer, Constanze

“…Acute myeloid leukemia (AML) is a heterogeneous disease caused by mutations in transcriptional regulator genes, but how different mutant regulators shape the…”
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Inter and intra-tumor heterogeneity of paediatric type diffuse high-grade gliomas revealed by single-cell mass cytometry by Petrilli, Lucia Lisa, Fuoco, Claudia, Palma, Alessandro, Pasquini, Luca, Pericoli, Giulia, Grabovska, Yura, Mackay, Alan, Rossi, Sabrina, Carcaboso, Angel M, Carai, Andrea, Mastronuzzi, Angela, Jones, Chris, Cesareni, Gianni, Locatelli, Franco, Vinci, Maria

“…Paediatric-type diffuse high-grade gliomas (PDHGG) are aggressive tumors affecting children and young adults, with no effective treatment. These highly…”
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Correction to: Molecular landscape of IDH-mutant primary astrocytoma Grade IV/Glioblastomas by Wong, Queenie Hoi-Wing, Li, Kay Ka-Wai, Wang, Wei-Wei, Malta, Tathiane M., Noushmehr, Houtan, Grabovska, Yura, Jones, Chris, Chan, Aden Ka-Yin, Kwan, Johnny Sheung-Him, Huang, Queenie Jun-Qi, Wong, Gabriel Chun-Hei, Li, Wen-Cai, Liu, Xian-Zhi, Chen, Hong, Chan, Danny Tat-Ming, Mao, Ying, Zhang, Zhen-Yu, Shi, Zhi-Feng, Ng, Ho-Keung

“…A Correction to this paper has been published: https://doi.org/10.1038/s41379-021-00802-0…”
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Molecular subgrouping of atypical teratoid/rhabdoid tumors—a reinvestigation and current consensus by Ho, Ben, Johann, Pascal D, Grabovska, Yura, De Dieu Andrianteranagna, Mamy Jean, Yao, Fupan, Frühwald, Michael, Hasselblatt, Martin, Bourdeaut, Franck, Williamson, Daniel, Huang, Annie, Kool, Marcel

“…Abstract Background Atypical teratoid/rhabdoid tumors (ATRTs) are known to exhibit molecular and clinical heterogeneity even though SMARCB1 inactivation is the…”
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Translational genomics of malignant rhabdoid tumours: Current impact and future possibilities by Finetti, Martina A., Grabovska, Yura, Bailey, Simon, Williamson, Daniel

“…Malignant Rhabdoid Tumours (MRT) are the quintessential example of an epigenetic cancer. Mutation of a single gene, SMARCB1 or more rarely SMARCA4, is capable…”
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DIPG-37. TRANSCRIPTIONAL, EPIGENETIC, AND IMMUNOLOGICAL FEATURES OF PAEDIATRIC-TYPE H3 K27-ALTERED DIFFUSE MIDLINE GLIOMAS ORIGINATING FROM DIFFERENT BRAIN LOCATIONS by Grabovska, Yura, Mackay, Alan, Pereira, Rita, Sejdiu, Drenusha, Burford, Anna, Temelso, Sara, Clarke, Matt, Jones, Chris

“…Abstract Diffuse midline gliomas (DMG) are highly aggressive brain tumours predominantly affecting young children. The main oncogenic driver is the…”
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DIPG-33. COMBINING CLONAL TRACKING WITH SINGLE CELL RNA SEQUENCING REVEALS TEMPORAL SHIFTS IN CELL STATES ASSOCIATED WITH TRAMETINIB RESISTANCE IN MAPK ALTERED DIFFUSE MIDLINE GLIOMA by Das, Molina, Grabovska, Yura, Collins, Jared, Rogers, Rebecca, Burford, Anna, Mackay, Alan, Beroukhim, Rameen, Bandopadhayay, Pratiti, Jones, Chris

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EXTH-41. COMBINED PHARMACOLOGICAL AND GENETIC SCREENING TO IDENTIFY DEPENDENCIES AND COMBINATIONS IN ACVR1-MUTANT DIFFUSE MIDLINE GLIOMA by Rogers, Rebecca, Carvalho, Diana, Grabovska, Yura, Fernandez, Elisabet, Izquierdo, Elisa, Mackay, Alan, Jones, Chris

“…Abstract Somatic mutations in ACVR1, which encodes the serine/threonine kinase ALK2, are found in 20-25% of DMG-H3K27 patients. Treatment of ACVR1-mutant…”
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DIPG-40. Combined pharmacological and genetic screening to identify dependencies and combinations in ACVR1-mutant diffuse midline glioma by Rogers, Rebecca, Carvalho, Diana, Grabovska, Yura, Fernandez, Elisabet, Izquierdo, Elisa, Mackay, Alan, Jones, Chris

“…Abstract Somatic mutations in ACVR1, which encodes the serine/threonine kinase ALK2, are found in 20-25% of DMG-H3K27 patients. Treatment of ACVR1-mutant…”
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Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma by Ross, James L, Chen, Zhihong, Herting, Cameron J, Grabovska, Yura, Szulzewsky, Frank, Puigdelloses, Montserrat, Monterroza, Lenore, Switchenko, Jeffrey, Wadhwani, Nitin R, Cimino, Patrick J, Mackay, Alan, Jones, Chris, Read, Renee D, MacDonald, Tobey J, Schniederjan, Matthew, Becher, Oren J, Hambardzumyan, Dolores

“…Paediatric high-grade gliomas (HGGs) account for the most brain tumour-related deaths in children and have a median survival of 12-15 months. One promising…”
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DIPG-10. SUBCLONAL POPULATIONS OF DIFFUSE MIDLINE GLIOMA CELLS PROMOTE TUMORIGENESIS THROUGH AP-1 TRANSCRIPTION FACTOR DYSREGULATION by Kessler, Ketty, Grabovska, Yura, Carvalho, Diana, Burford, Anna, Temelso, Sara, Tari, Haider, Molinari, Valeria, Crampsie, Shauna, Yu, Lu, Choudhary, Jyoti, Proszek, Paula, Hubank, Mike, Mackay, Alan, Jones, Chris

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PATH-17. INTRAGENIC COPY NUMBER BREAKPOINT ANALYSIS OF METHYLATION DATA FROM CNS TUMOURS IDENTIFIES NOVEL SUBGROUP-SPECIFIC CANDIDATE FUSION GENE ENRICHMENTS by Mackay, Alan, Grabovska, Yura, Clarke, Matthew, Carvalho, Diana, Temelso, Sara, Jones, Chris

“…Abstract Methylation array-based molecular profiling has redefined the classification of brain tumours and now forms an important part of their integrated…”
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Abstract 2120: Interrogation of regulatory and expression changes in Malignant Rhabdoid Tumours to identify new therapeutic approaches by Lishman-Walker, Emma L., Finetti, Martina A., Hacking, James P., Selby, Matthew, Grabovska, Yura, Crosier, Stephen, Bailey, Simon, Clifford, Steven C., Williamson, Daniel

“…Abstract Malignant Rhabdoid Tumors (MRTs) are a textbook model of epigenetic dysregulation within cancer. The biallelic inactivation of a single gene SMARCB1…”
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DIPG-53. AN EXCEPTIONALLY RARE CASE OF A DIFFUSE MIDLINE GLIOMA WITH CONCOMITANT H3.1 K27M AND G34R MUTATIONS IN THEHIST1H3C (H3C3) GENE by Reisz, Zita, Pereira, Rita, Nevis, Smitha, Mackay, Alan, Bhaw, Leena, Grabovska, Yura, Laxton, Ross, Molinari, Valeria, Burford, Anna, Clark, Barnaby, Bleil, Cristina, Zebian, Bassel, Weiser, Annette, Carceller, Fernando, Marshall, Lynley, King, Andrew, Bodi, Istvan, Al-Sarraj, Safa, Jones, Chris, Clarke, Matthew

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Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development by Williamson, Daniel, Schwalbe, Edward C., Hicks, Debbie, Aldinger, Kimberly A., Lindsey, Janet C., Crosier, Stephen, Richardson, Stacey, Goddard, Jack, Hill, Rebecca M., Castle, Jemma, Grabovska, Yura, Hacking, James, Pizer, Barry, Wharton, Stephen B., Jacques, Thomas S., Joshi, Abhijit, Bailey, Simon, Clifford, Steven C.

“…Medulloblastoma is currently subclassified into distinct DNA methylation subgroups/subtypes with particular clinico-molecular features. Using RNA sequencing…”
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Multiomics Analysis of IMiD/CELMoD Resistant Multiple Myeloma Models Uncovers Novel and Targetable Vulnerabilities in the SREBP Lipid Synthesis Pathway by Bird, Sarah A., Barber, Amy, Sialana, Fernando J., Licciardello, Marco P., Che, Harvey, Bouguenina, Habib, Grabovska, Yura, Liu, Enze, Chrisochoidou, Yakinthi, Martin, Shannon, Choudhary, Jyoti, Walker, Brian A., Collins, Ian, Clarke, Paul, Pawlyn, Charlotte

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EPCO-24. MULTI-OMIC PROFILING OF PATIENT-DERIVED SUBCLONES IDENTIFIES AGGRESSIVE CELLULAR SUBPOPULATIONS IN PAEDIATRIC DIFFUSE HIGH GRADE GLIOMAS (PDHGGS) by Kessler, Ketty, Grabovska, Yura, Burford, Anna, Temelso, Sara, Tari, Haider, Molinari, Valeria, Crampsie, Shauna, Yu, Lu, Choudhary, Jyoti, Proszek, Paula, Hubank, Mike, Mackay, Alan, Jones, Chris

“…Abstract Paediatric-type diffuse high-grade gliomas are classified into distinct subgroups based upon their location and defining molecular alterations, with…”
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The Significance of Clinico-Pathological and Molecular Sub-Groups in Malignant Rhabdoid Tumours by Grabovska, Yura

“…Introduction: Malignant Rhabdoid Tumours (MRT) are aggressive early childhood tumours characterised by biallelic inactivation of SMARCB1. Having the potential…”
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