Ontogeny of Cloned Cattle to Lactation

Ontogeny of Cloned Cattle to Lactation

Central to the success of large animal cloning is the production of healthy animals that can provide products for human health, food, and other animal agriculture applications. We report development of cloned cattle derived from 34 genetically unique, nonembryonic cell lines using nuclear transfer p...

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Bibliographic Details
Published in:Biology of reproduction Vol. 67; no. 1; pp. 334 - 339
Main Authors: Pace, Marvin M, Augenstein, Monica L, Betthauser, Jeffery M, Childs, Lynette A, Eilertsen, Kenneth J, Enos, Joellyn M, Forsberg, Erik J, Golueke, Paul J, Graber, Doug F, Kemper, John C, Koppang, Richard W, Lange, Gail, Lesmeister, Tiffany L, Mallon, Kelly S, Mell, Greg D, Misica, Pavla M, Pfister-Genskow, Martha, Strelchenko, Nikolai S, Voelker, Gary R, Watt, Steven R, Bishop, Michael D
Format: Journal Article
Language:English
Published: Madison, WI Society for the Study of Reproduction 01-07-2002
Subjects:
Abortion, Spontaneous - epidemiology
Animals
Biological and medical sciences
Birth Weight - physiology
Body Weight - physiology
Cattle
Cell Line
Cloning, Organism
Contents
Eating - physiology
Embryo Transfer
Embryology: invertebrates and vertebrates. Teratology
Embryonic and Fetal Development - physiology
Estrus - physiology
Female
Fertilization in Vitro - methods
Fundamental and applied biological sciences. Psychology
Growth - physiology
Lactation - physiology
Molecular embryology
Nuclear Transfer Techniques
parturition
Parturition - physiology
Pregnancy
Survival Analysis
Ultrasonography
Animal cloning
Embryonic development
Vertebrata
Mammalia
Growth
Ox
Artiodactyla
Postnatal development
Survival
Ungulata
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Summary:Central to the success of large animal cloning is the production of healthy animals that can provide products for human health, food, and other animal agriculture applications. We report development of cloned cattle derived from 34 genetically unique, nonembryonic cell lines using nuclear transfer performed between 1 January 1998 and 29 February 2000. Nearly 25% (535/2170) of the recipients receiving reconstructed embryos initiated pregnancy. Overall, 19.8% (106/535) of the initiated pregnancies resulted in live births, while 77% (82/106) of these cattle clones remain healthy and productive today. Although a wide variation in birth weight of clone calves was observed, their growth rates, reproductive performance, and lactation characteristics are similar to that found in noncloned dairy cattle. Our data represent the most comprehensive information on cattle derived from nuclear transfer procedures and indicate that this emerging reproductive technology offers unique opportunities to meet critical needs in both human health care and agriculture.
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ISSN:0006-3363
1529-7268
DOI:10.1095/biolreprod67.1.334