Search Results - "Graaf, Winette T.A."

Imatinib, sunitinib and pazopanib: From flat‐fixed dosing towards a pharmacokinetically guided personalized dose by Westerdijk, Kim, Desar, Ingrid M.E., Steeghs, Neeltje, Graaf, Winette T.A., Erp, Nielka P.

“…Tyrosine kinase inhibitors (TKIs) are anti‐cancer drugs that target tyrosine kinases, enzymes that are involved in multiple cellular processes. Currently,…”
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Prevalence, Impact and Correlates of Severe Fatigue in Patients with Gastrointestinal Stromal Tumors by Poort, Hanneke, MSc, van der Graaf, Winette T.A., MD, PhD, Tielen, Ronald, MD, Vlenterie, Myrella, MD, Custers, José A.E., MSc, Prins, Judith B., PhD, Verhagen, Stans A.H.H.V.M., MD, PhD, Gielissen, Marieke F.M., PhD, Knoop, Hans, PhD

“…Abstract Context The introduction of the tyrosine kinase inhibitor (TKI) imatinib in the treatment of gastrointestinal stromal tumor (GIST) in 2000 was the…”
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Pazopanib, a promising option for the treatment of aggressive fibromatosis by Szucs, Zoltan, Messiou, Christina, Wong, Han Hsi, Hatcher, Helen, Miah, Aisha, Zaidi, Shane, van der Graaf, Winette T.A, Judson, Ian, Jones, Robin L, Benson, Charlotte

“…Desmoid tumour/aggressive fibromatosis (DT/AF) is a rare soft-tissue neoplasm that is locally aggressive but does not metastasize. There is no standard…”
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The insulin-like growth factor 1 receptor in cancer: Old focus, new future by Hartog, Hermien, Wesseling, Jelle, Boezen, H. Marike, van der Graaf, Winette T.A

“…Abstract The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour of tumour cells is well established. Currently,…”
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The EORTC QLQ‐C30 Summary Score as Prognostic Factor for Survival of Patients with Cancer in the “Real‐World”: Results from the Population‐Based PROFILES Registry by Husson, Olga, Rooij, Belle H., Kieffer, Jacobien, Oerlemans, Simone, Mols, Floortje, Aaronson, Neil K., Graaf, Winette T.A., Poll‐Franse, Lonneke V.

“…Background Health‐related quality of life (HRQoL) has been shown to be a prognostic factor for cancer survival in randomized clinical trials and observational…”
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Expression and clinical relevance of MET and ALK in Ewing sarcomas by Fleuren, Emmy D.G., Roeffen, Melissa H.S., Leenders, William P., Flucke, Uta E., Vlenterie, Myrella, Schreuder, Hendrik W., Boerman, Otto C., Graaf, Winette T.A., Versleijen‐Jonkers, Yvonne M.H.

“…Because novel therapeutic options are limited in Ewing sarcomas (ES), we investigated the expression, genetic aberrations and clinical relevance of MET and…”
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Surgical management of rectal gastrointestinal stromal tumors by Tielen, Ronald, Verhoef, Cornelis, van Coevorden, Frits, Reyners, Anna K., van der Graaf, Winette T.A., Bonenkamp, Johannes J., van Etten, Boudewijn, de Wilt, Johannes H.W.

“…Background Five percent of gastrointestinal stromal tumors (GISTs) are primarily localized in the rectum. We analyzed the outcome of multimodality treatment…”
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Prognostic Significance of Bone Metastasis in Soft Tissue Sarcoma Patients Receiving Palliative Systemic Therapy: An Explorative, Retrospective Pooled Analysis of the EORTC-Soft Tissue and Bone Sarcoma Group (STBSG) Database by Kantidakis, Georgios, Litière, Saskia, Gelderblom, Hans, Fiocco, Marta, Judson, Ian, van der Graaf, Winette T.A., Italiano, Antoine, Marréaud, Sandrine, Sleijfer, Stefan, Mechtersheimer, Gunhild, Messiou, Christina, Kasper, Bernd

“…Background. Soft-tissue sarcomas (STS) constitute a rare group of heterogeneous mesenchymal tumours containing more than 100 histologic subtypes. Here, we…”
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Role of Endogenous Vascular Endothelial Growth Factor in Endothelium-Dependent Vasodilation in Humans by Thijs, Anna M.J, van Herpen, Carla M.L, Sweep, Fred C.G.J, Geurts-Moespot, Anneke, Smits, Paul, van der Graaf, Winette T.A, Rongen, Gerard A

“…Angiogenesis inhibitors have remarkably improved the outcome of patients with several types of cancer. Hypertension is the most reported side effect of…”
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Simultaneous targeting of insulin-like growth factor-1 receptor and anaplastic lymphoma kinase in embryonal and alveolar rhabdomyosarcoma: A rational choice by van Gaal, J. Carlijn, Roeffen, Melissa H.S, Flucke, Uta E, van der Laak, Jeroen A.W.M, van der Heijden, Gwen, de Bont, Eveline S.J.M, Suurmeijer, Albert J.H, Versleijen-Jonkers, Yvonne M.H, van der Graaf, Winette T.A

“…Abstract Background Rhabdomyosarcoma (RMS) is an aggressive soft tissue tumour mainly affecting children and adolescents. Since survival of high-risk patients…”
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Mycobacterium ulcerans disease by VAN DER WERF, Tjip S, STIENSTRA, Ymkje, ASIEDU, Kingsley, JOHNSON, R. Christian, PHILLIPS, Richard, ADJEI, Ohene, FLEISCHEJ, Bernhard, WANSBROUGH-JONES, Mark H, JOHNSON, Paul D. R, PORTAELS, Francoise, VAN DER GRAAF, Winene T. A

“…Mycobacterium ulcerans disease (Buruli ulcer) is an important health problem in several west African countries. It is prevalent in scattered foci around the…”
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The relationship between sunitinib exposure and both efficacy and toxicity in real‐world patients with renal cell carcinoma and gastrointestinal stromal tumour by Westerdijk, Kim, Krens, Stefanie D., Graaf, Winette T.A., Mulder, Sasja F., Herpen, Carla M.L., Smilde, Tineke, Erp, Nielka P., Desar, Ingrid M.E.

“…Aim Sunitinib is an oral tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST). Because…”
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The Effect of Using Pazopanib With Food vs. Fasted on Pharmacokinetics, Patient Safety, and Preference (DIET Study) by Lubberman, Floor J.E., Gelderblom, Hans, Hamberg, Paul, Vervenne, Walter L., Mulder, Sasja F., Jansman, Frank G.A., Colbers, Angela, Graaf, Winette T.A., Burger, David M., Luelmo, Saskia, Moes, Dirk Jan A.R., van Herpen, Carla M.L., van Erp, Nielka P.

“…Pazopanib is taken fasted in a fixed oral daily dose of 800 mg. We hypothesized that ingesting pazopanib with food may improve patients’ comfort and reduce…”
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‘Big’-Insulin-Like Growth Factor–II Signaling Is an Autocrine Survival Pathway in Gastrointestinal Stromal Tumors by Rikhof, Bart, van der Graaf, Winette T.A, Suurmeijer, Albert J.H, van Doorn, Jaap, Meersma, Gert Jan, Groenen, Patricia J.T.A, Schuuring, Ed M.D, Meijer, Coby, de Jong, Steven

“…New treatment targets need to be identified in gastrointestinal stromal tumors (GISTs) to extend the treatment options for patients experiencing failure with…”
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Incidence, Survival, and Mortality Trends of Cancers Diagnosed in Adolescents and Young Adults (15–39 Years): A Population-Based Study in The Netherlands 1990–2016 by van der Meer, Daniël J., Karim-Kos, Henrike E., van der Mark, Marianne, Aben, Katja K. H., Bijlsma, Rhodé M., Rijneveld, Anita W., van der Graaf, Winette T. A., Husson, Olga

“…Adolescent and young adult (AYA) cancer patients, aged 15–39 years at primary cancer diagnosis, form a distinct, understudied, and underserved group in cancer…”
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Expected survival with and without second‐line palliative chemotherapy: who wants to know? by Oostendorp, Linda J.M., Ottevanger, Petronella B., Wouw, Agnes J., Schoenaker, Ivonne J.H., Graaf, Hiltje, Graaf, Winette T.A., Stalmeier, Peep F.M.

“…Background According to surveys, many patients with advanced cancer wish to receive survival information. Objective This study investigated information…”
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Patient-Reported Outcomes of Accelerated Aging: A Novel Approach to Investigate Second Cancer Risk in Adolescent and Young Adult (18-39 Years) Cancer Survivors by van der Meer, Daniël J, Zevenbergen, Susan, Vlooswijk, Carla, Bijlsma, Rhodé M, Kaal, Suzanne E J, Kerst, Jan Martijn, Tromp, Jacqueline M, Bos, Monique E M M, van der Hulle, Tom, Lalisang, Roy I, Nuver, Janine, Kouwenhoven, Mathilde C M, van der Graaf, Winette T A, Husson, Olga

“…Adolescent and young adult cancer survivors (AYAs, aged 18-39 years at first diagnosis) have a higher second cancer risk. Accelerated aging is hypothesized as…”
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Histopathologic features of Mycobacterium ulcerans infection by Guarner, Jeannette, Bartlett, Jeanine, Whitney, Ellen A Spotts, Raghunathan, Pratima L, Stienstra, Ymkje, Asamoa, Kwame, Etuaful, Samuel, Klutse, Erasmus, Quarshie, Eric, van der Werf, Tjip S, van der Graaf, Winette T A, King, C Harold, Ashford, David A

“…Because of the emergence of Buruli ulcer disease, the World Health Organization launched a Global Buruli Ulcer Initiative in 1998. This indolent skin infection…”
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Neoadjuvant Systemic Treatment of Primary Angiosarcoma by Heinhuis, Kimberley M., IJzerman, Nikki S., van der Graaf, Winette T. A., Kerst, Jan Martijn, Schrage, Yvonne, Beijnen, Jos H., Steeghs, Neeltje, van Houdt, Winan J.

“…Angiosarcoma is an extremely rare and aggressive malignancy. Standard of care of localized tumors includes surgery ± radiation. Despite this multimodal…”
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Exploring the interconnectedness between health-related quality of life factors among long-term adolescent and young adult cancer survivors (AYAs): a network analysis by Bootsma, Tom I., van de Wal, Deborah, Vlooswijk, Carla, Roos, Daniëlle C., Drabbe, Cas, Tissier, Renaud, Bijlsma, Rhodé M., Kaal, Suzanne E.J., Kerst, Jan Martijn, Tromp, Jacqueline M., Bos, Monique E.M.M., van der Hulle, Tom, Lalisang, Roy I., Nuver, Janine, Kouwenhoven, Mathilde C.M., van der Graaf, Winette T.A., Janssen, Silvie H.M., Husson, Olga

“…Purpose Adolescent and young adult cancer survivors (AYAs) are at increased risk of long-term and late effects, and experience unmet needs, impacting their…”
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