Search Results - "Graab, Ulrike"

Synthetic lethal interaction between PI3K/Akt/mTOR and Ras/MEK/ERK pathway inhibition in rhabdomyosarcoma by Guenther, Monika Katharina, Graab, Ulrike, Fulda, Simone

“…Highlights • PI3K inhibitor PI103 and MEK inhibitor U0126 synergize to trigger apoptosis in RMS. • PI103 and U0126 converge to block PI3K/mTOR and ERK…”
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Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death by Schott, Christina, Graab, Ulrike, Cuvelier, Nicole, Hahn, Heidi, Fulda, Simone

“…Recent genomic studies revealed a high rate of recurrent mutations in the RAS pathway in primary rhabdomyosarcoma (RMS) samples. In the present study, we…”
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Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma by Graab, Ulrike, Hahn, Heidi, Fulda, Simone

“…We previously reported that aberrant HH pathway activation confers a poor prognosis in rhabdomyosarcoma (RMS). Searching for new treatment strategies we…”
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PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells by Marklein, Diana, Graab, Ulrike, Naumann, Ivonne, Yan, Tiandong, Ridzewski, Rosalie, Nitzki, Frauke, Rosenberger, Albert, Dittmann, Kai, Wienands, Jürgen, Wojnowski, Leszek, Fulda, Simone, Hahn, Heidi

“…We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy…”
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Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs by Meister, Michael Torsten, Boedicker, Cathinka, Graab, Ulrike, Hugle, Manuela, Hahn, Heidi, Klingebiel, Thomas, Fulda, Simone

“…Highlights • ATO reduces cell viability and clonogenic survival and triggers apoptosis in RMS cells. • ATO upregulates Noxa, which is required for ATO-induced…”
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