Search Results - "Grünewald, Sylvia"

Correction: Effects of regorafenib on the mononuclear/phagocyte system and how these contribute to the inhibition of colorectal tumors in mice by Grünewald, Sylvia, Stecklum, Maria, Rizzo, Manuel, Rathjens, Jonathan, Fiebig, Lukas, Zopf, Dieter

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Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance by Quanz, Maria, Bender, Eckhard, Kopitz, Charlotte, Grünewald, Sylvia, Schlicker, Andreas, Schwede, Wolfgang, Eheim, Ashley, Toschi, Luisella, Neuhaus, Roland, Richter, Carmen, Toedling, Joern, Merz, Claudia, Lesche, Ralf, Kamburov, Atanas, Siebeneicher, Holger, Bauser, Marcus, Hägebarth, Andrea

“…The lactate transporter /monocarboxylate transporter 1 (MCT1) plays a central role in tumor cell energy homeostasis. In a cell-based screen, we identified a…”
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Monitoring regulated protein-protein interactions using split TEV by Laage, Rico, Rossner, Moritz J, Wehr, Michael C, Bolz, Ulrike, Fischer, Tobias M, Grünewald, Sylvia, Scheek, Sigrid, Bach, Alfred, Nave, Klaus-Armin

“…Signaling cascades integrate extracellular stimuli primarily through regulated protein-protein interactions (PPIs). Intracellular signal transduction strictly…”
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Effects of regorafenib on the mononuclear/phagocyte system and how these contribute to the inhibition of colorectal tumors in mice by Grünewald, Sylvia, Stecklum, Maria, Rizzo, Manuel, Rathjens, Jonathan, Fiebig, Lukas, Zopf, Dieter

“…Regorafenib was previously shown to reduce tumor-associated macrophages and potently inhibit colony-stimulating factor 1 receptor (CSF1R), also known as CD115,…”
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Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis by Sugawara, Tatsuo, Nevedomskaya, Ekaterina, Heller, Simon, Böhme, Annika, Lesche, Ralf, Ahsen, Oliver, Grünewald, Sylvia, Nguyen, Holly M., Corey, Eva, Baumgart, Simon J., Georgi, Victoria, Pütter, Vera, Fernández‐Montalván, Amaury, Vasta, James D., Robers, Matthew B., Politz, Oliver, Mumberg, Dominik, Haendler, Bernard

“…Prostate cancer is a frequent malignancy in older men and has a very high 5‐year survival rate if diagnosed early. The prognosis is much less promising if the…”
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Factors affecting the substrate specificity of histone deacetylases by Riester, Daniel, Hildmann, Christian, Grünewald, Sylvia, Beckers, Thomas, Schwienhorst, Andreas

“…Histone deacetylases (HDACs) catalyze the deacetylation of ε-acetyl-lysine residues within the N-terminal tail of core histones and thereby mediate changes in…”
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Lipid composition of Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) insect cells used for baculovirus infection by Marheineke, Kathrin, Grünewald, Sylvia, Christie, William, Reiländer, Helmut

“…The lipid composition of two different insect cell lines from Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) which are established cell lines for…”
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Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4 by Schneider, Armin, Laage, Rico, Von Ahsen, Oliver, Fischer, Achim, Rossner, Moritz, Scheek, Sigrid, Grünewald, Sylvia, Kuner, Rohini, Weber, Daniela, Krüger, Carola, Klaussner, Bettina, Götz, Bernhard, Hiemisch, Holger, Newrzella, Dieter, Martin‐Villalba, Ana, Bach, Alfred, Schwaninger, Markus

“…Cerebral ischaemia induces transcriptional changes in a number of pathophysiologically important genes. Here we have systematically studied gene expression…”
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Novel TIE‐2 inhibitor BAY‐826 displays in vivo efficacy in experimental syngeneic murine glioma models by Schneider, Hannah, Szabo, Emese, Machado, Raquel A. C., Broggini‐Tenzer, Angela, Walter, Alexander, Lobell, Mario, Heldmann, Dieter, Süssmeier, Frank, Grünewald, Sylvia, Weller, Michael

“…Targeting the vascular endothelial growth factor signaling axis in glioblastoma inevitably leads to tumor recurrence and a more aggressive phenotype…”
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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity by Vriens, Kim, Christen, Stefan, Parik, Sweta, Broekaert, Dorien, Yoshinaga, Kazuaki, Talebi, Ali, Dehairs, Jonas, Escalona-Noguero, Carmen, Schmieder, Roberta, Cornfield, Thomas, Charlton, Catriona, Romero-Pérez, Laura, Rossi, Matteo, Rinaldi, Gianmarco, Orth, Martin F., Boon, Ruben, Kerstens, Axelle, Kwan, Suet Ying, Faubert, Brandon, Méndez-Lucas, Andrés, Kopitz, Charlotte C., Chen, Ting, Fernandez-Garcia, Juan, Duarte, João A. G., Schmitz, Arndt A., Steigemann, Patrick, Najimi, Mustapha, Hägebarth, Andrea, Van Ginderachter, Jo A., Sokal, Etienne, Gotoh, Naohiro, Wong, Kwok-Kin, Verfaillie, Catherine, Derua, Rita, Munck, Sebastian, Yuneva, Mariia, Beretta, Laura, DeBerardinis, Ralph J., Swinnen, Johannes V., Hodson, Leanne, Cassiman, David, Verslype, Chris, Christian, Sven, Grünewald, Sylvia, Grünewald, Thomas G. P., Fendt, Sarah-Maria

“…Most tumours have an aberrantly activated lipid metabolism 1 , 2 that enables them to synthesize, elongate and desaturate fatty acids to support proliferation…”
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Rogaratinib: A potent and selective pan‐FGFR inhibitor with broad antitumor activity in FGFR‐overexpressing preclinical cancer models by Grünewald, Sylvia, Politz, Oliver, Bender, Sebastian, Héroult, Mélanie, Lustig, Klemens, Thuss, Uwe, Kneip, Christoph, Kopitz, Charlotte, Zopf, Dieter, Collin, Marie‐Pierre, Boemer, Ulf, Ince, Stuart, Ellinghaus, Peter, Mumberg, Dominik, Hess‐Stumpp, Holger, Ziegelbauer, Karl

“…Aberrant activation in fibroblast growth factor signaling has been implicated in the development of various cancers, including squamous cell lung cancer,…”
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Expression of the human D2S dopamine receptor in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe: A comparative study by Sander, Peter, Grünewald, Sylvia, Reiländer, Helmut, Michel, Hartmut

“…The yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe were tested for heterologous expression of the human D2S dopamine receptor. The cDNA coding…”
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Expression of Calnexin Reflects Paneth Cell Differentiation and Function by Gassler, Nikolaus, Schnölzer, Martina, Rohr, Claudia, Helmke, Burkhard, Kartenbeck, Jürgen, Grünewald, Sylvia, Laage, Rico, Schneider, Armin, Kränzlin, Bettina, Bach, Alfred, Otto, Herwart F, Autschbach, Frank

“…It has been suggested that the behavior and function of Paneth cells in metaplasia are different from those found in normal intestinal mucosa. In this study,…”
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Abstract 5036: Correlation of preclinical antitumor activity of regorafenib in CRC-PDX xenografts with gene expression and clinical parameters of the primary tumor by Seidel, Henrik, Hoffmann, Jens, Lesche, Ralf, Grünewald, Sylvia, Henderson, David, Zopf, Dieter

“…Abstract Regorafenib is a small molecule inhibitor of multiple transmembrane and intracellular kinases involved in normal cellular functions and in pathologic…”
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Discovery of Rogaratinib (BAY 1163877): a pan‐FGFR Inhibitor by Collin, Marie‐Pierre, Lobell, Mario, Hübsch, Walter, Brohm, Dirk, Schirok, Hartmut, Jautelat, Rolf, Lustig, Klemens, Bömer, Ulf, Vöhringer, Verena, Héroult, Mélanie, Grünewald, Sylvia, Hess‐Stumpp, Holger

“…Rogaratinib (BAY 1163877) is a highly potent and selective small‐molecule pan‐fibroblast growth factor receptor (FGFR) inhibitor (FGFR1–4) for oral application…”
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Role of Heteromer Formation in GABA$_B$ Receptor Function by Kuner, Rohini, Köhr, Georg, Grünewald, Sylvia, Eisenhardt, Gisela, Bach, Alfred, Kornau, Hans-Christian

“…Recently, GBR1, a seven-transmembrane domain protein with high affinity for γ-aminobutyric acid (GABA)$_B$ receptor antagonists, was identified. Here, a…”
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In Vivo Reconstitution of Dopamine D2S Receptor-Mediated G Protein Activation in Baculovirus-Infected Insect Cells:  Preferred Coupling to Gi1 versus Gi2 by Grünewald, Sylvia, Reiländer, Helmut, Michel, Hartmut

“…Agonist binding of the human D2S receptor overexpressed in baculovirus-infected Sf9 insect cells was of low affinity and GppNHp-insensitive, yet, dopaminergic…”
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Ellipsoid Segmentation Model for Analyzing Light-Attenuated 3D Confocal Image Stacks of Fluorescent Multi-Cellular Spheroids by Barbier, Michaël, Jaensch, Steffen, Cornelissen, Frans, Vidic, Suzana, Gjerde, Kjersti, de Hoogt, Ronald, Graeser, Ralph, Gustin, Emmanuel, Chong, Yolanda T

“…In oncology, two-dimensional in-vitro culture models are the standard test beds for the discovery and development of cancer treatments, but in the last…”
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Abstract 1698: Systems pathology for characterization of cancer model systems in a multicenter IMI-PREDECT project by Blom, Sami, Wang, Yinhai, Metsalu, Tauno, Vesterinen, Tiina, Pellinen, Teijo, Grote, Anne, Linder, Nina, Säilä, Jenni, Välimäki, Katja, Kovanen, Ruusu-Maria, Monni, Outi, Kovanen, Panu, Davies, Emma, Stock, Kristin, Estrada, Marta, Sflomos, Georgios, Grünewald, Sylvia, Brito, Catarina, Schüler, Julia, de Hoogt, Ronald, Brisken, Cathrin, van der Kuip, Heiko, van Weerden, Wytske, Barry, Simon, Sommergruber, Wolgang, Anderson, Elizabeth, Nees, Matthias, Klefström, Juha, Vilo, Jaak, Verschuren, Emmy, Graeser, Ralph, Hickman, John, Lundin, Johan, Kallioniemi, Olli

“…Abstract Despite of our increased understanding of cancer biology, the majority of anti-cancer therapies fail at late-stage clinical trials. Thus, there is an…”
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Importance of the gamma-aminobutyric acid(B) receptor C-termini for G-protein coupling by Grünewald, Sylvia, Schupp, Bettina J, Ikeda, Stephen R, Kuner, Rohini, Steigerwald, Frank, Kornau, Hans-Christian, Köhr, Georg

“…Functional gamma-aminobutyric acid(B) (GABA(B)) receptors assemble from two subunits, GABA(B(1)) and GABA(B(2).) This heteromerization, which involves a…”
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