PRACTICABILITY OF PATIENT SELF-TESTING OF ORAL ANTICOAGULANT THERAPY BY THE INTERNATIONAL NORMALIZED RATIO (INR) USING A PORTABLE WHOLE BLOOD MONITOR. A pilot investigation

PRACTICABILITY OF PATIENT SELF-TESTING OF ORAL ANTICOAGULANT THERAPY BY THE INTERNATIONAL NORMALIZED RATIO (INR) USING A PORTABLE WHOLE BLOOD MONITOR. A pilot investigation

The prophylactic efficacy of long-term oral anticoagulant treatment (OAT) has been demonstrated in a number of clinical conditions with increased tendency to thromboembolism, and the number of individuals subjected to OAT in the industrialised world has increased substantially in recent years. Since...

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Bibliographic Details
Published in:Thrombosis research Vol. 85; no. 1; pp. 77 - 82
Main Authors: Hasenkam, J.Michael, Knudsen, Lars, Kimose, Hans Henrik, Grønnesby, Hanne, Attermann, Jørn, Andersen, Niels Trolle, Pilegaard, Hans K
Format: Journal Article
Language:English
Published: New York, NY Elsevier Ltd 1997
Elsevier Science
Subjects:
Administration, Oral
Anticoagulants - administration & dosage
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
CoaguChek
Humans
international normalized ration (INR)
Medical sciences
near patient testing
Oral anticoagulant therapy
Pharmacology. Drug treatments
Pilot Projects
Prothrombin Time
Thrombosis - blood
Thrombosis - prevention & control
near patient testing
Oral anticoagulant therapy
international normalized ration (INR)
CoaguChek
Human
Whole blood
Blood coagulation
Chemotherapy
Treatment
Surveillance
Oral administration
Self control
Anticoagulant
Portable equipment
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Summary:The prophylactic efficacy of long-term oral anticoagulant treatment (OAT) has been demonstrated in a number of clinical conditions with increased tendency to thromboembolism, and the number of individuals subjected to OAT in the industrialised world has increased substantially in recent years. Since this therapy requires considerable resources from both the health care system and the patients, the feasibility of patients' self-monitoring and self-management of OAT has been investigated (1,2,3). The anticipated advantages of this approach include improved convenience and compliance for the patient, who may increase his apprehension for managing the treatment. In addition, self-testing allows for more frequent control compared to the conventional out-patient approach. Importantly, a prerequisite for conceiving a safe and operational concept for patient self-management (PSM) is the availability of a portable INR monitoring system with an accuracy, precision, reproducibility, and long-term reliability comparable to standard coagulometric equipment. The purpose of the present study was to evaluate the feasibility of a commercially available INR-monitor. CoaguChek, for patient self-testing, through a step-wise investigation of the performance characteristics of the equipment in the laboratory, in command of the patient, and during self-testing and self-adjustment of treatment at home. Laboratory INR values were used as reference.
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content type line 23
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(96)00224-1