Search Results - "Grée, D."

Synthesis of New Optically Active Propargylic Fluorides and Application to the Enantioselective Synthesis of Monofluorinated Analogues of Fatty Acid Metabolites by Prakesch, Michaël, Grée, Danielle, Grée, René

“…A new approach to obtain optically active unsaturated or polyunsaturated systems with a single fluorine atom in an allylic or propargylic position is reported…”
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Mitochondrial targeting by use of lipid nanocapsules loaded with SV30, an analogue of the small-molecule Bcl-2 inhibitor HA14-1 by Weyland, M., Manero, F., Paillard, A., Grée, D., Viault, G., Jarnet, D., Menei, P., Juin, P., Chourpa, I., Benoit, J.-P., Grée, R., Garcion, E.

“…Taking advantage from the development of SV30, a new analogue of the pro-apoptotic molecule HA14-1, the aim of this study was to functionally evaluate SV30 and…”
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Synthesis of the 9-fluoro analogues of disparlure by Filmon, Jérôme, Grée, Danielle, Grée, René

“…Starting from a propargylic fluoride, a three step sequence led to syn and anti 9-fluoro analogues of the disparlure pheromone. During these studies an unusual…”
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A new strategy for the synthesis of optically active benzylic fluorides and corresponding five-membered heteroaromatic analogues by Grée, Danielle, Grée, René

“…Benzylic fluorides, as well as five-membered heterocycles, have been obtained in high ee’s through cycloaddition reactions starting from easily accessible…”
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Conformations of Allylic Fluorides and Stereoselectivities of Their Diels−Alder Cycloadditions by Grée, Danielle, Vallerie, Laurent, Grée, René, Toupet, Loic, Washington, Ilyas, Pelicier, Jean-Pierre, Villacampa, Mercedes, Pérez, José María, Houk, K. N

“…The preparations of new allylic fluorides from the corresponding alcohols are reported. Conformational analysis is achieved by comparison of experimental NMR…”
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New Enantioselective Synthesis of Monofluorinated Pyridines Designed for the Preparation of Chemical Libraries by Blayo, Anne-Laure, Le Meur, Stéphanie, Grée, Danielle, Grée, René

“…Chiral pyridines with a fluorine atom in the benzylic position are easily accessible from optically active propargylic fluorides by using the Bohlmann–Rahtz…”
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Synthesis of new selected analogues of the proapoptotic and anticancer molecule HA 14-1 by Grée, D., Vorin, S., Manthati, V.L., Caijo, F., Viault, G., Manero, F., Juin, P., Grée, R.

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The small organic compound HA14-1 sensitizes human glioblastoma cells to induction of cell death through inhibition of Bcl-2 by Manero, F., Gautier, F., Gallenne, T., Cauquil, N., Grée, D., Cartron, P.F., Geneste, O., Grée, R., Vallette, M., Juin, P.

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The propargylic route as efficient entry to monofluoro and gem-difluoro compounds: mechanistic considerations by Prakesch, Michael, Kerouredan, Erwan, Grée, Danielle, Grée, René, DeChancie, Jason, Houk, K.N.

“…The dehydroxy-fluorination of propargylic alcohols occurs with a complete regiocontrol and a good to complete stereocontrol, in contrast to the reactions…”
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Enantioselective Synthesis of methyl-5-(R)-fluorohep-6-ynoate by Manthati, V.L., Murthy, A.S.K., Caijo, F., Drouin, D., Lesot, P., Grée, D., Grée, R.

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Microwave Spectrum of 1-Cyano-3-fluoro-but-1-ene by Kassi, S., Grée, D., Grée, R., Duflot, D., Petitprez, D., Wlodarczak, G.

“…The rotational spectrum of the 1-cyano-3-fluoro-but-1-ene has been recorded with a pulsed-nozzle microwave Fourier transform spectrometer over the range 6–20…”
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The small organic compound HA14-1 prevents Bcl-2 interaction with bax to sensitize malignant glioma cells to induction of cell death by MANERO, Florence, GAUTIER, Fabien, GALLENNE, Tristan, CAUQUIL, Nicolas, GREE, Danielle, CARTRON, Pierre-Francois, GENESTE, Olivier, GREE, René, VALLETTE, Francois M, JUIN, Philippe

“…A functional imbalance between proapoptotic Bax and antiapoptotic Bcl-2 is likely to participate in the resistance of cancer cells to therapy. We show here…”
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The Propargylic Route as a Short and Versatile Entry to Optically Active Monofluorinated Compounds by Prakesch, Michaël, Grée, Danielle, Grée, René

“…Using selected models and appropriate NMR techniques, it has been demonstrated that dehydroxyfluorination in the propargylic position can be highly regio- and…”
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Synthesis of Fluoro Analogues of Unsaturated Fatty Acids and Corresponding Acyclic Metabolites by Prakesch, Michaël, Grée, Danielle, Chandrasekhar, Srivari, Grée, René

“…Polyunsaturated fatty acids, in particular arachidonic acid and its metabolites, the so‐called eicosanoids, play a major role in human health. Many of them…”
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Stereoselective Synthesis of the 5,5‐Difluoro‐(12 R )‐ and ‐(12 S )‐Leukotrienes B 3 by Lingam Manthati, Vijaya, Grée, Danielle, Grée, René

“…Abstract The first synthesis of the 5,5‐difluoro‐(12 R )‐ and ‐(12 S )‐leukotrienes B 3 is reported which uses a flexible and convergent strategy. The key…”
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A Facile C−C Bond Cleavage in the Epoxides and Its Use for the Synthesis of Oxygenated Heterocycles by a Ring Expansion Strategy by Lakshmipathi, Pandarinathan, Grée, Danielle, Grée, René

“…The bicyclic epoxy alcohols when treated with DAST gave a new class of rearranged organofluorine compounds, by a ring expansion via C−C bond cleavage of the…”
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Synthesis and reactivity of Z and E functionalized allylic fluorides by Prakesch, Michaël, Grée, Danielle, Grée, René

“…The allylic fluorides 1 and 2 are used as models to study the effect of the allylic C–F bond on the diastereoselectivity of reactions occurring on the vicinal…”
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Stereoselectivity of Nitrile Oxide Cycloadditions to Chiral Allylic Fluorides: Experiment and Theory by Prakesch, Michael, Grée, Danielle, Grée, René, Carter, Jennifer, Washington, Ilyas, Houk, K. N.

“…The cycloadditions of nitrile oxides with new and previously studied allylic fluorides were examined. The 1,3‐dipolar cycloaddition reactions were also…”
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A Straightforward and Flexible [4 + 2] Route to β-C-Naphthyl-2-deoxy-glycosides through Tandem Hydroboration-Ketal Reduction: De Novo Access to C-Naphthyl-6-fluoro and 6,6-Difluoro 2-Deoxyglycosides by Vu, Nguyen Quang, Leconte, Stéphane, Brown, Eric, Grée, Danielle, Grée, René, Dujardin, Gilles

“…Under standard hydroboration-oxidation conditions, the dihydropyrans 4 underwent a highly stereocontrolled tandem reaction, involving the expected hydration of…”
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Regiocontrolled fluorination of 2-hydroxyalkyl dihydropyrans and carbonyl derivatives by Vu, Nguyen Quang, Grée, Danielle, Grée, René, Brown, Eric, Dujardin, Gilles

“…Reaction of polysubstituted 2-hydroxyalkyldihydropyrans with DAST led regiospecifically to fluorination at the exocyclic position, except for primary alcohols…”
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