Search Results - "Gräbner, Rolf"
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Mouse Aorta Smooth Muscle Cells Differentiate Into Lymphoid Tissue Organizer-Like Cells on Combined Tumor Necrosis Factor Receptor-1/Lymphotoxin β-Receptor NF-κB Signaling
Published in Arteriosclerosis, thrombosis, and vascular biology (01-03-2010)“…OBJECTIVE—Mouse aorta smooth muscle cells (SMC) express tumor necrosis factor receptor superfamily member 1A (TNFR-1) and lymphotoxin β-receptor (LTβR)…”
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Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice
Published in Atherosclerosis (01-04-2009)“…Abstract The 5-lipoxygenase (5-LO) catalyzed formation of leukotriene (LT) lipid mediators is a pathway contributing to inflammatory events in asthma and more…”
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3
Control of dichotomic innate and adaptive immune responses by artery tertiary lymphoid organs in atherosclerosis
Published in Frontiers in physiology (01-01-2012)“…Tertiary lymphoid organs (TLOs) emerge in tissues in response to non-resolving inflammation such as chronic infection, graft rejection, and autoimmune disease…”
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The Lamina Adventitia Is the Major Site of Immune Cell Accumulation in Standard Chow-Fed Apolipoprotein E–Deficient Mice
Published in Arteriosclerosis, thrombosis, and vascular biology (01-11-2005)“…OBJECTIVE—Cells of adaptive immunity have been implicated in atherogenesis. Though substantial information is available on immune cells in atherosclerotic…”
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The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm
Published in Nature medicine (01-09-2004)“…Activation of the 5-lipoxygenase (5-LO) pathway leads to the biosynthesis of proinflammatory leukotriene lipid mediators. Genetic studies have associated 5-LO…”
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Expanding Expression of the 5-Lipoxygenase Pathway within the Arterial Wall during Human Atherogenesis
Published in Proceedings of the National Academy of Sciences - PNAS (04-02-2003)“…Oxidation products of low-density lipoproteins have been suggested to promote inflammation during atherogenesis, and reticulocyte-type 15-lipoxygenase has been…”
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Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice
Published in The Journal of experimental medicine (16-01-2009)“…Atherosclerosis involves a macrophage-rich inflammation in the aortic intima. It is increasingly recognized that this intimal inflammation is paralleled over…”
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l-Ascorbic Acid Potentiates Nitric Oxide Synthesis in Endothelial Cells
Published in The Journal of biological chemistry (19-03-1999)“…Ascorbic acid has been shown to enhance impaired endothelium-dependent vasodilation in patients with atherosclerosis by a mechanism that is thought to involve…”
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Hypochlorite-modified Low Density Lipoprotein Inhibits Nitric Oxide Synthesis in Endothelial Cells via an Intracellular Dislocalization of Endothelial Nitric-oxide Synthase
Published in The Journal of biological chemistry (27-04-2001)“…Hypochlorous acid/hypochlorite, generated by the myeloperoxidase/H 2 O 2 /halide system of activated phagocytes, has been shown to oxidize/modify low density…”
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Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin β Receptors
Published in Immunity (Cambridge, Mass.) (16-06-2015)“…Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in…”
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11
Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling
Published in Arteriosclerosis, thrombosis, and vascular biology (01-03-2010)“…Mouse aorta smooth muscle cells (SMC) express tumor necrosis factor receptor superfamily member 1A (TNFR-1) and lymphotoxin beta-receptor (LTbetaR)…”
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12
Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin [beta] Receptors
Published in Immunity (Cambridge, Mass.) (16-06-2015)“…Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in…”
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13
Influence of cationic amphiphilic drugs on the phosphatidylcholine hydrolysis by phospholipase A2
Published in Biochemical pharmacology (01-04-1987)“…On chronic treatment certain amphiphilic drugs induce a generalized phospholipidosis. This drug side effect has been related to an inhibition of the lysosomal…”
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Flow cytometric determination of E‐selectin, vascular cell adhesion molecule‐1, and intercellular cell adhesion molecule‐1 in formaldehyde‐fixed endothelial cell monolayers
Published in Cytometry (New York, N.Y.) (01-07-2000)“…Background Endothelial cell adhesion molecules are involved in initiation and progression of vascular diseases. The purpose of this study was to determine…”
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Laser-capture microdissection of hyperlipidemic/ApoE⁻/⁻ mouse aorta atherosclerosis
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2011)“…Atherosclerosis is a transmural chronic inflammatory condition of small and large arteries that is associated with adaptive immune responses at all disease…”
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Incorporation in liposomes as a method for the application of genotoxins of low water solubility in the SCE assay
Published in Mutation research (01-01-1984)“…Benzo[alpha]pyrene BaP), freely dissolved or incorporated in liposomes prepared from egg yolk lecithin, was checked for SCE induction in Chinese hamster V79-E…”
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