Search Results - "Gozzard, N."

TNF‐α‐induces airway hyperresponsiveness to cholinergic stimulation in guinea pig airways by Makwana, R, Gozzard, N, Spina, D, Page, C

“…BACKGROUND AND PURPOSE TNF‐α is an inflammatory cytokine implicated in the pathogenesis of asthma and it causes airway inflammation, bronchoconstriction and…”
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CDP840. A prototype of a novel class of orally active anti-Inflammatory phosphodiesterase 4 inhibitors by Alexander, R.P., Warrellow, G.J., Eaton, M.A.W., Boyd, E.C., Head, J.C., Porter, J.R., Brown, J.A., Reuberson, J.T., Hutchinson, B., Turner, P., Boyce, B., Barnes, D., Mason, B., Cannell, A., Taylor, R.J., Zomaya, A., Millican, A., Leonard, J., Morphy, R., Wales, M., Perry, M., Allen, R.A., Gozzard, N., Hughes, B., Higgs, G.

“…The discovery, synthesis and biological activity of a series of triarylethane phosphodiesterase 4 inhibitors is described. Structure–activity relationship…”
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The effect of anti-integrin monoclonal antibodies on antigen-induced pulmonary inflammation in allergic rabbits by Gascoigne, M.H, Holland, K, Page, C.P, Shock, A, Robinson, M, Foulkes, R, Gozzard, N

“…The integrin adhesion molecules are involved in the recruitment and activation of inflammatory cells at sites of inflammation in a variety of diseases. In the…”
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In vitro and in vivo characterisation of anti-murine IL-13 antibodies recognising distinct functional epitopes by Berry, L.M., Adams, R., Airey, M., Bracher, M.G., Bourne, T., Carrington, B., Cross, A.S., Davies, G.C.G., Finney, H.M., Foulkes, R., Gozzard, N., Griffin, R.A., Hailu, H., Lamour, S.D., Lawson, A.D., Lightwood, D.J., McKnight, A.J., O'Dowd, V.L., Oxbrow, A.K.F., Popplewell, A.G., Shaw, S., Stephens, P.E., Sweeney, B., Tomlinson, K.L., Uhe, C., Palframan, R.T.

“…Interleukin-13 (IL-13) sequentially binds to IL-13Rα1 and IL-4Rα forming a high affinity signalling complex. This receptor complex is expressed on multiple…”
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The inhibition of antigen‐induced eosinophilia and bronchoconstriction by CDP840, a novel stereo‐selective inhibitor of phosphodiesterase type 4 by Hughes, B., Howat, D., Lisle, H., Holbrook, M., James, T., Gozzard, N., Blease, K., Hughes, P., Kingaby, R., Warrellow, G., Alexander, R., Head, J., Boyd, E., Eaton, M., Perry, M., Wales, M., Smith, B., Owens, R., Catterall, C., Lumb, S., Russell, A., Allen, R., Merriman, M., Bloxham, D., Higgs, G.

“…1 The novel tri‐aryl ethane CDP840, is a potent and selective inhibitor of cyclic AMP phosphodiesterase type 4 (PDE 4) extracted from tissues or recombinant…”
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Inhibition of bronchospasm and ozone‐induced airway hyperresponsiveness in the guinea‐pig by CDP840, a novel phosphodiesterase type 4 inhibitor by Holbrook, Mark, Gozzard, Neil, James, Tina, Higgs, Gerry, Hughes, Bernadette

“…1 The activity of CDP840, a novel, potent and selective cyclic nucleotide phosphodiesterase type 4 (PDE 4) inhibitor, was evaluated in guinea‐pig models (in…”
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Capsaicin pre-treatment prevents the development of antigen-induced airway hyperresponsiveness in neonatally immunised rabbits by Herd, Caroline M., Gozzard, Neil, Page, Clive P.

“…The effect of a 3-day pre-treatment regime of capsaicin (8-methyl- N-vanillyl-6-nonenamide) (80 mg/kg s.c.) on airway changes induced by Alternaria tenuis…”
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Effect of the glucocorticosteroid budesonide and a novel phosphodiesterase type 4 inhibitor CDP840 on antigen‐induced airway responses in neonatally immunised rabbits by Gozzard, N., El‐Hashim, A., Herd, C.M., Blake, S.M., Holbrook, M., Hughes, B., Higgs, G.A., Page, C.P.

“…1 The effects of the inhaled corticosteroid budesonide and a novel PDE 4 inhibitor CDP840 given systemically, were evaluated in a model of antigen‐induced…”
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Effects of theophylline and rolipram on antigen‐induced airway responses in neonatally immunized rabbits by Gozzard, N., Herd, C.M., Blake, S.M., Holbrook, M., Hughes, B., Higgs, G.A., Page, C.P.

“…1 The effects of the xanthine, theophylline, a non‐selective phosphodiesterase (PDE) inhibitor, and the phosphodiesterase type 4 (PDE 4) inhibitor, rolipram,…”
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C32 ASTHMA: PRE-CLINICAL STUDIES: Corticosteroid Insensitivity In A House Dust Mite And Freund's Complete Adjuvant Driven Mouse Model Of Allergic Asthma by Raemdonck, K, Birrell, M A, Gozzard, N, Chung, K F, Belvisi, M G, Adcock, I M

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TNF-[alpha]-induces airway hyperresponsiveness to cholinergic stimulation in guinea pig airways by Makwana, R, Gozzard, N, Spina, D, Page, C

“…BACKGROUND AND PURPOSE TNF-[alpha] is an inflammatory cytokine implicated in the pathogenesis of asthma and it causes airway inflammation, bronchoconstriction…”
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C32 CLINICAL ASTHMA II: Transcriptomics Analysis Identifies The Persistent Activation Of Peripheral Airways In Glucocorticosteroid-Treated Severe Asthmatics by Singhania, A, Rupani, H, Jayasekera, N, Lumb, S, Hales, P, Gozzard, N, Davies, D E, Woelk, C H, Howarth, P H

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The RA-MAP Consortium: a working model for academia–industry collaboration by Cope, Andrew P., Barnes, Michael R., Belson, Alexandra, Binks, Michael, Brockbank, Sarah, Bonachela-Capdevila, Francisco, Carini, Claudio, Fisher, Benjamin A., Goodyear, Carl S., Emery, Paul, Ehrenstein, Michael R., Gozzard, Neil, Harris, Ray, Hollis, Sally, Keidel, Sarah, Levesque, Marc, Lindholm, Catharina, McDermott, Michael F., McInnes, Iain B., Mela, Christopher M., Parker, Gerry, Read, Simon, Pedersen, Ayako Wakatsuki, Ponchel, Frederique, Porter, Duncan, Rao, Ravi, Rowe, Anthony, Schulz-Knappe, Peter, Sleeman, Matthew A., Symmons, Deborah, Taylor, Peter C., Tom, Brian, Tsuji, Wayne, Verbeeck, Denny, Isaacs, John D.

“…Large partnerships between academia and industry are emerging as a possible solution to the problems surrounding stratified medicine. In this Perspectives…”
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Certolizumab Pegol and Adalimumab Accumulation in the Inflammed Paws of Mice with Collagen-induced Arthritis Compared to Noninflammed Tissue In Vivo Biofluorescence Imaging of Alexa 680-labeled Antibodies by Palframan, Roger, Senior Group Leader, UCB Celltech, Pharmacology, Slough, UK, Vugler, Alex, Research Scientist, UCB Celltech, Pharmacology, Slough, UK, Moore, Adrian, Senior Group Leader, UCB Celltech, Pharmacology, Slough, UK, Baker, Mark, Research Scientist, UCB Celltech, Clinical Pharmacology and Experimental Medicine, Slough, UK, Lightwood, Daniel, Group Leader, UCB Celltech, Antibody Biology, Slough, UK, Nesbitt, Andrew, Senior Group Leader, UCB Celltech, Inflammation Discovery, Slough, UK, Foulkes, Roly, Director, UCB Celltech, Non-clinical Development/Inflammation Therapeutic Area, Slough, UK, Gozzard, Neil, Director, UCB Celltech, Pharmacology, Slough, UK

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Discovery and evaluation of potent, tyrosine-based alpha4beta1 integrin antagonists by Archibald, S C, Head, J C, Gozzard, N, Howat, D W, Parton, T A, Porter, J R, Robinson, M K, Shock, A, Warrellow, G J, Abraham, W M

“…Using disulphide cysteine-based inhibitors as lead structures, this communication describes our strategy for identifying more stable, potent antagonists of the…”
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